EGFR靶向治疗中敏感性预测指标的启示

EGFR抗肿瘤靶向治疗药物临床疗效存在明显个体差异,与其疗效敏感性相关的预测标志物能指导临床用药,成为临床关注的热点,本文从哲学的角度思考靶向治疗敏感性预测指标与恶性肿瘤的关系,试图以此为指导,更好地加强临床用药的预见性.     

晚期非小细胞肺癌化疗的冷思考

晚期非小细胞肺癌提倡以化疗为主综合治疗,可以延长生存期,提高生存率.但目前化疗取得的疗效虽然较既往有提高,但提高生存期有限,且在药效经济学方面存在争议,缓解症状的作用也有限,联合靶向治疗的疗效也在观望中.临床肿瘤学工作者应正确认识,以循证医学为指导,开展规范化化疗,同时也注重个体化化疗,并期待晚期非小细胞肺癌化疗的新突破.     

晚期非小细胞肺癌化疗的冷思考

晚期非小细胞肺癌提倡以化疗为主综合治疗,可以延长生存期,提高生存率。但目前化疗取得的疗效虽然较既往有提高,但提高生存期有限,且在药效经济学方面存在争议,缓解症状的作用也有限,联合靶向治疗的疗效也在观望中。临床肿瘤学工作者应正确认识,以循证医学为指导,开展规范化化疗,同时也注重个体化化疗,并期待晚期非小细胞肺癌化疗的新突破。     

从系统论看肿瘤的生物靶向性治疗

肿瘤的生物靶向性治疗是恶性肿瘤治疗的新方法,其试图通过在基因水平上调节与肿瘤发生、发展有密切联系的生命物质来达到治愈肿瘤的目的。但临床运用中,生物靶向性治疗的疗效与我们的想象相去甚远。本文运用系统论的观点,分析目前生物靶向性治疗中存在的问题及寻求可能解决的方法。     

靶向药物不良反应的认识与思考

新的靶向药物出现提高了抗癌疗效,降低了毒性,使转移性恶性肿瘤患者从治疗中获益。靶向药物耐受性好,通常出现轻微或中度的毒副反应。尽管大多数不良反应是可以得到迅速处理的,但是严重的甚至危及生命的不良反应仍能够发生。因此,为更好地指导临床实践工作,该文综述了实体瘤治疗中常用靶向药物的主要不良反应和安全数据,并按照药物的作用靶...     

靶向药物不良反应的认识与思考

新的靶向药物出现提高了抗癌疗效.降低了毒性,使转移性恶性肿瘤患者从治疗中获益.靶向药物耐受性好.通常出现轻微或中度的毒副反应.尽管大多数不良反应是可以得到迅速处理的,但是严重的甚至危及生命的不良反应仍能够发生.因此.为更好地指导临床实践工作.该文综述了实体瘤治疗中常用靶向药物的主要不良反应和安全数据,并按照药物的作用靶点和信号通路进行了组织分类.     

应用分子靶向治疗的时机选择

分子靶向药物的出现显示出肿瘤治疗传统模式的重要进展。与传统放疗、化疗相比,分子靶向治疗因其特异性高、不良反应轻微,在恶性肿瘤个体化治疗中扮演重要角色。十五年来,分子靶向药物的出现,给肿瘤的治疗模式带来重大改变,也给临床医生带来新的挑战。准确把握分子靶向药物应用时机,获得最大临床效果,已成为肿瘤治疗领域关注热点。本文就非小细胞肺癌、消化系统肿瘤、乳腺癌、肾癌治疗中分子靶向药物如何选择应用时机进行阐述。     

慢性粒细胞白血病治疗方案选择的分析

随着对慢性粒细胞白血病（CML）发病机制研究的深入,在细胞遗传学基础上引入了分子生物学技术,使CML的治疗提高到了个体化、系统化的新阶段。结合现代新兴的分子靶向治疗,对CML治疗方法发展概况辩证性、系统性地分析,指导临床选择合适的治疗方法,以争取达到最佳治疗效果。     

抗菌药物合理应用的宏观和微观问题

抗菌药物不合理应用现象长期得不到纠正,细菌耐药稳步攀升,正引起医学界、社会和政府的高度关注.本文就宏观上的抗菌药物使用政策与微观上的临床用药两方面存在的问题进行探讨.介绍了国际上关于抗菌药物政策的研究以及抗菌药物合理使用的新观点(尽早开始经验性治疗、"降阶梯"治疗策略、运用抗菌药物PK/PD原理指导临床用药、短程治疗).主张调整宏观抗生素策略,去除该政策单纯、片面限制使用和应用药敏实验结果指导临床用药绝对化的做法,吸纳国际上的新成果,强化监管力度,更多采用教育和技术手段.     

近年结肠癌NCCN指南变化初探

NCCN结肠癌临床实践指南是基于丰富循证医学证据建立的高水平、规范化治疗指南。近年来,随着临床证据的不断丰富和积累,指南对一些临床问题的处理进行了调整,有的原则发生了变化。本文通过对历年不同版本指南的比较,对手术方式及病理评估、术后辅助化疗、晚期治疗方案和分子靶向治疗等几方面指导意见的变化进行了初步探讨分析。     

年龄相关性黄斑变性治疗的比较分析

从治疗原理、费用、疗效、不良反应等方面对年龄相关性黄斑变性的不同治疗方法进行比较和分析,为患者进行治疗上的选择提供帮助,同时指导和规范该类疾病治疗的临床决策,以期能在目前条件下不仅提高病人的治疗效果和生活质量同时又达到降低医疗费用的目的。     

原发性三叉神经痛两种治疗方法的比较

原发性三叉神经痛的治疗方法以神经毁损术最为常用。通过对经皮射频热凝毁损术和阿霉素化学毁损术的疗效、安全性、复发率、并发症及费用等方面的比较,揭示两种方法的利弊。用比较治疗学的理念及方法来指导三叉神经痛治疗的临床决策,以期能在目前条件下提高患者的治疗效果、降低医疗费用及提高生活质量。     

Emotional Intelligence: An Opportunity for Occupational Therapy

Emotional intelligence theory developed within the psychology and business fields and is described as an ability to monitor emotions and to use the information to guide thinking and problem solving. Emotional intelligence skills are needed by occupational therapy practitioners to support therapeutic use of self, promote client-centered care, and foster communication skills within the workplace. A scenario illustrates how emotional intelligence supports the therapeutic use of self during a clinical interaction. The Mayer Salovey Caruso Emotional Intelligence Test is introduced as a resource for occupational therapy practitioners to measure and develop therapeutic relationship skills based upon emotional intelligence research.     

Uncommon strategies for a common problem: addressing racism in family therapy

Race and racism have a profound effect on our daily lives and the practice of family therapy. Whether individual or institutional level, overt or covert, intentional or unintentional, there are a variety of ways in which racism can infiltrate the therapeutic process. Before therapists can take steps to address racism effectively within the context of family therapy, it is important to attend to the development of their racial awareness and racial sensitivity. These provide the critical foundation upon which specific skills and strategies associated with effectively identifying and responding to racism in therapy are based. This article defines racial awareness and sensitivity and provides suggestions for enhancing both. In the section that follows, three major ways in which racism can infiltrate the therapeutic process are described. Skills and strategies for addressing each of these in family therapy are presented.     

Survivin与子宫内膜癌的基因治疗的思考

子宫内膜癌是妇科常见的恶性肿瘤,发病机制不很清楚,早期诊断及治疗可改善预后,而目前的手术治疗方式损伤较大。Survivin是近年发现的新凋亡抑制基因,在多数恶性肿瘤组织中表达丰富,而在正常成人组织中不表达,这种表达特异性使其成为肿瘤诊断和基因治疗的新靶点。本文着重思考以Survivin为靶点的基因治疗方法在子宫内膜癌中的应用。     

Perinatal Posttraumatic Stress Disorder: Implications for Occupational Therapy in Early Intervention Practice

The purpose of this article is to present literature regarding perinatal posttraumatic stress disorder and to describe the implications of research findings for occupational therapy screening and treatment in early intervention practice. Changes in legislation regarding early intervention practice and family centered care are presented as a rationale for including maternal mental health screening as a standard practice in the field of early intervention. A case study illustrates symptoms of perinatal posttraumatic stress disorder and the effect on maternal-infant co-occupational engagement. The Model of Human Occupation is used to guide clinical reasoning about potential occupational therapy interventions.     

The therapeutic alliance in couples therapy: clinical considerations

This article presents clinical considerations about the therapeutic alliance in couples therapy, stimulated by pertinent new research findings reported in this issue. A loyalty dimension of the couple's relationship is described, as well as its influence on the therapeutic alliance in couples therapy. The therapist's establishment of a "meta-alliance" with the couple around their loyalty conflicts, avoidance of splits and disruptions, and prioritization of marital distress (versus individual symptoms) as the primary focus of treatment all serve to solidify the therapeutic alliance. In addition, identifying the partners' early family-of-origin distress can help predict and respond to strains in the therapeutic alliance that may occur later in therapy. Finally, the therapist helping the couple to balance their relational power differences in therapy and to address their concerns about the impact of the therapist's gender also strengthens their therapeutic alliance. A clinical case and vignettes are included to illustrate these issues.     

Guided Recovery: An Interpretative Phenomenological Analysis of Service Users’ Experiences of Guided Self-Help for Bulimic and Binge Eating Disorders

The efficacy of Cognitive Behavioral Therapy–based Guided Self-Help for mild to moderate bulimia and binge eating disorders has been well supported. However, limited research has explored in-depth individual experiences of this treatment approach. In-depth semi-structured interviews were conducted with 4 individuals who had completed Cognitive Behavioral Therapy–based Guided Self-Help (CBT-GSH) for bulimic or binge eating disorders. The interviews were transcribed verbatim and subsequently analyzed using Interpretative Phenomenological Analysis (IPA). Three superordinate themes emerged: Autonomy and volition; A dynamic relationship: the guided and the guide; and The unwanted friend. The reciprocal nature of the guide/guided relationship was identified as integral to the success of the therapeutic approach. However, participants expressed initial uncertainty towards the therapeutic process, and experienced an uncomfortable dissonance between a lack of volition in therapy seeking and the need to continually self-prescribe CBT-GSH. The findings affirm the central role of the guide in promoting motivation to engage with therapy and highlight the potential benefits of in-session weighing. However, it may be necessary to provide additional support on commencing CBT-GSH to address concerns about the therapeutic approach in this group.     

案例概念化在临床上的应用

随着心理治疗方法的发展, 案例概念化作为治疗工作的重要组成部分, 日益成为临床关注的热点。案例概念化主要指在一定治疗理论的基础上, 就来访者的问题成因和维持因素提出假设, 为构建治疗方案提供指导蓝图。西方的临床研究表明案例概念化能有效地促进咨询师和来访者对于问题的认识和理解, 提高治疗效果。以认知行为治疗理论为基础, 具体地介绍案例概念化技术在焦虑症和抑郁症的临床应用。