母婴分离的动物模型及其神经生物学机制

利用社会环境剥夺建立的精神分裂症动物模型,是当前研究精神分裂症神经生物学机制的一个热点课题.作为一种重要的早期社会剥夺方式,出生后至断乳前的母婴分离日益受到关注.文章综合阐述了母婴分离对啮齿类动物行为及神经发育影响的最新研究成果,表明母婴分离可以部分模拟精神分裂症的行为及中枢表现,证实了该模型的可行性;并进一步分析了影响实验结果的各种相关因素,为今后采用该模型进行深入研究提供一定的理论支持.     

Turning Up the Heat: Inflammation as a Mechanism Linking Chronic Stress, Depression, and Heart Disease

ABSTRACT— Mounting evidence indicates that chronic stressors and depressive symptoms contribute to morbidity and mortality from cardiac disease. However, little is known about the underlying mechanisms responsible for these effects or about why depressive symptoms and cardiac disease co-occur so frequently. In this article we outline a novel model that seeks to address these issues. It asserts that chronic stressors activate the immune system in a way that leads to persistent inflammation. With long-term exposure to the products of inflammation, people develop symptoms of depression and experience progression of atherosclerosis, the pathologic condition that underlies cardiac disease.     

一个中枢炎性免疫诱发长时程抑郁样行为的新模型

脂多糖(lipopolysaccharide, LPS)免疫激活模型是研究抑郁症细胞因子假说的重要动物模型, 目前国际上常用外周单次LPS注射诱发抑郁样行为, 但该模型中抑郁样行为持续仅有数小时。为建立诱发较长时程抑郁样行为的免疫激活动物模型, 本研究尝试侧脑室注射LPS激活大鼠中枢免疫炎性反应, 考察单次以及重复中枢LPS注射诱发抑郁样行为的效果, 以及中枢炎性免疫诱发行为改变的时程。结果显示：单次中枢LPS注射后24 h只能诱发旷场自发活动和探索行为下降等部分抑郁样行为, 未能诱导糖水偏好下降和悬尾不动时间增加; 3次重复注射则在末次LPS注射后24 h表现出显著的糖水偏好下降, 自发活动和探索行为减少, 悬尾不动时间增加等行为。且自发活动、探索行为减少和悬尾不动时间增加能够延续至末次LPS注射后72 h。这些结果表明脑室重复LPS注射可诱发较长时程的抑郁样行为, 这种新的中枢炎性免疫激活诱发的抑郁症模型, 为研究抑郁症炎性免疫机制提供了更为有效的动物模型, 有助于深入探讨行为和免疫功能间的复杂关系。     

亲子分离与青少年同伴侵害和抑郁的关系:一项追踪研究

采用追踪研究设计,对贵州省1094名青少年进行了间隔半年的两次测查,考察早期亲子分离对青少年后期同伴侵害经历及抑郁水平的影响及性别差异。结果表明：（1）早期亲子分离能显著增加T1同伴侵害和抑郁,并通过T1的同伴侵害和抑郁间接影响T2的同伴侵害和抑郁;（2）亲子分离、同伴侵害和抑郁的关系存在显著性别差异：在女生组中,早期亲子分离不仅能够显著增加T1抑郁水平,还通过影响T1抑郁间接影响T2的同伴侵害状况,且早期亲子分离也可以边缘显著预测T1的同伴侵害状况;在男生组中,亲子分离仅能显著预测T1的同伴侵害经历,对于T1抑郁及T2时间点的各变量则无显著影响;（3）无论是否受到亲子分离的影响,同伴侵害与青少年抑郁之间均存在相互作用关系。研究结果提示早期亲子分离会导致青少年后期同伴侵害经历及抑郁水平上升,且主要体现在女生群体中,这为经历亲子分离后青少年心理健康干预方案的制定提供了科学依据。     

父亲、母亲抚养压力在母亲抑郁和学龄前儿童内外部问题行为间的链式中介作用

研究旨在探讨父亲和母亲的抚养压力在母亲抑郁与学龄前儿童内、外部问题行为间的作用。以北京市某区75所幼儿园的2222名3~5岁在园幼儿及其父母为被试,采用《流调中心抑郁量表》、《抚养压力量表》、《学龄前儿童问题行为问卷》分别对母亲抑郁、父母抚养压力及儿童问题行为进行测查,结果发现：（1）母亲抑郁可以正向预测儿童的内、外部问题行为;（2）母亲抑郁对儿童内部问题行为的作用被"母亲抚养压力"、"母亲抚养压力-父亲抚养压力"两条路径部分中介;（3）母亲抑郁对儿童外部问题行为的作用被"母亲抚养压力"、"母亲抚养压力-父亲抚养压力"两条路径完全中介。综上,研究揭示了母亲抚养压力、父亲抚养压力在母亲抑郁和学龄前儿童内、外部问题行为间的链式中介作用。     

白细胞介素-1在病态行为中的作用及其机制

白细胞介素－1（interleukin-1,IL-1）是介导神经－免疫活动的关键分子,在应激状态时出现IL-1活性增强,注射IL-1可以引发病态行为。外周释放的IL-1通过快通路和慢通路作用于大脑进而引发病态行为,快通路是指局部的初级传入神经将信息传入大脑,慢通路是指IL-1从环脑室器官和脉络从扩散进入大脑。     

抑郁认知易感性的新解释——双重加工模型

双重加工模型认为人类拥有两种信息加工模式,联想模式是快速、不需努力的加工,以良好学习联想(Well-learned associations)为基础:反思模式是慢速的、需要付出努力的加工,建立在基于规则的符号推理基础上,联想模式的发生是自动化的,当预期被违反时,执行反思模式,并需要足够的认知资源.当反思加工没有校正消极的有偏向的联想加工时,就会表现出抑郁的认知易感性.双重加工模型对抑郁认知易感性的评估、病原学和治疗提出了新的看法.     

The Body-Machine Interface: A New Perspective on an Old Theme

ABSTRACT

Body-machine interfaces establish a way to interact with a variety of devices, allowing their users to extend the limits of their performance. Recent advances in this field, ranging from computer interfaces to bionic limbs, have had important consequences for people with movement disorders. The authors provide an overview of the basic concepts underlying the body-machine interface with special emphasis on their use for rehabilitation and for operating assistive devices. They outline the steps involved in building such an interface and highlight the critical role of body-machine interfaces in addressing theoretical issues in motor control as well as their utility in movement rehabilitation.     

焦虑和抑郁动物模型的研究方法和策略

焦虑和抑郁障碍是严重威胁人们健康的精神疾病。焦虑和抑郁动物模型是通过一定的心理社会应激使动物产生明显的焦虑和抑郁情绪,模拟人类焦虑和抑郁障碍,以探讨其细胞、分子和基因水平机制。情绪障碍动物模型通常通过表面效度、结构效度和预测效度进行评价。目前的动物模型虽然存在一定的缺点,但已经为临床和科研提供了巨大帮助。     

青少年抑郁:基于社会支持的视角

青少年罹患抑郁的社会因素受到研究者们的密切关注,尤其是社会支持因素。本文首先总结了社会支持与青少年抑郁关系的内在机制,包括主效应机制和缓冲效应机制;其次论述了影响社会支持与青少年抑郁关系的多种因素,主要涉及来自于社会支持提供者、社会支持接受者和测量方法等方面的因素。社会支持提供者因素包括性别、数量和社会地位;社会支持接受者因素包括性别、年龄、个体内在特征、人格特征以及遗传;此外方法主要涉及社会支持与抑郁症的测量。最后提出了未来的研究方向,如测量方法的改进、元分析纵向研究的开展、线上支持的研究,为青少年抑郁的社会干预提供更多的研究视角。     

缰核在抑郁症中的作用:研究和治疗的新途径

缰核是哺乳动物神经系统中连接前脑和中脑的重要节点,这一古老的核团因其与抑郁症的密切联系,近来获得国内外研究者的关注.缰核接受来自边缘系统、基底神经节等的传入信号,向下投射到中脑5-羟色胺系统和多巴胺系统.在应激条件下缰核免疫活动增强,向下游的投射信号增强,以此调节单胺类递质释放,参与抑郁症的发病机制,并且参与抗抑郁治疗的起效途径.这些证据提示缰核在抑郁症中具有重要作用,将成为研究和治疗的新途径.未来研究应从缰核与上下游核团的神经联系、与丘脑-垂体-肾上腺轴的相互影响、以及与免疫激活的交互作用等方面进一步探索,为研究抑郁症病理机制和治疗方法提供线索.     

青少年抑郁:基于社会支持的视角

青少年罹患抑郁的社会因素受到研究者们的密切关注,尤其是社会支持因素。本文首先总结了社会支持与青少年抑郁关系的内在机制,包括主效应机制和缓冲效应机制;其次论述了影响社会支持与青少年抑郁关系的多种因素,主要涉及来自于社会支持提供者、社会支持接受者和测量方法等方面的因素。社会支持提供者因素包括性别、数量和社会地位;社会支持接受者因素包括性别、年龄、个体内在特征、人格特征以及遗传;此外方法主要涉及社会支持与抑郁症的测量。最后提出了未来的研究方向,如测量方法的改进、元分析纵向研究的开展、线上支持的研究,为青少年抑郁的社会干预提供更多的研究视角。     

Insecure Attachment and Subclinical Depression,Anxiety, and Stress: A Three-Dimensional Model of Personality Self-Regulation As a Mediator

Although the effects of insecure attachment on vulnerability, incidence, and developing mental disorders have been confirmed by many studies, the mechanism of this effect is still unknown. Therefore, the main aim of this study was to investigate the mediating and moderating role of the three-dimensional model of personality self-regulation in the relationship between insecure attachment and subclinical depression, anxiety, and stress. Four hundred Iranian students at Shiraz University were recruited and completed the following scales: the Revised Adult Attachment, Depression Anxiety Stress, Integrative Self-Knowledge, Mindful Attention Awareness, Self-Control, and Self-Compassion. Results showed that there was a moderate correlation among all the variables under study in the expected directions. Multiple mediating models analyses indicated that regarding the relationship between insecure attachment and depression, the components of integrative self-knowledge, self-control, and self-compassion functioned as mediators. However, regarding the relationship between insecure attachment and anxiety and stress, the components of integrative self-knowledge, mindfulness, and self-compassion relatively functioned as mediators. Further, our results showed that only mindfulness and self-compassion were identified as moderators in the relationship between insecure attachment and depression. It is concluded that insecure attachment may cause psychological damage due to deficiency in the components of the three-dimensional model of personality self-regulation, and that mindfulness and self-compassion may play a protective role in the relationship between insecure attachment and depression.     

倦怠、应激和抑郁

倦怠是“在以人为服务对象的职业领域中,个体的一种情感耗竭、人格解体和个人成就感降低的症状”。在倦怠研究的文献中,存在着严重的倦怠、应激和抑郁的概念混淆现象。文章对工作倦怠、工作应激和抑郁的联系与区别进行了详细阐述,并指明了未来的研究方向,具有重要的理论意义。     

Peer Rejection in Childhood: Effects on Maternal Depression and Behavior Problems in Toddlers

The aim of this study was to develop a conceptual model that would clarify how a woman's recollections of peer and parent rejection in childhood influence her emotional well-being and, resultantly, her own child's behavior problems. Given current interest in peer versus parent influences, the authors used a design and analysis to reveal the unique contributions of peer and parent rejection. The participants were a community sample of 88 mothers and their 2 1/2-year-old children. The study found that mothers' recollections of peer rejection in childhood were significantly associated with depressive symptomatology, but recollections of parental rejection in childhood were unrelated to current depressive symptoms. Recollections of peer rejection during childhood, internal representation of self, and depressive symptoms made significant, unique contributions to the variance in behavior problems in their children. Together, these variables significantly explained 27% of the variance in the final model.     

抑郁症神经成像研究的临床转化:预防、诊断和治疗的新取向

抑郁症的预防、诊断和治疗是临床所面临的主要问题,其效果的提升有待超越传统方法,寻求新的方法和技术。其中抑郁症的神经成像转化研究为此提供了一个新的突破口,该研究取向旨在将抑郁症的神经成像基础研究的发现转化为临床运用。文章综述了其在抑郁症的预防、诊断和治疗上的潜在运用价值。未来方向需要更好地促进抑郁症神经成像转化研究的双向自由流通、强调将新的方法转化到日常的临床实践和健康决策上去、促进多学科的合作和相关人才的培养,以及进一步探究转化过程中所面临的特定基础和临床主题。     

Parenting Sensitivity,Parental Depression and Child Health: The Mediational Role of Parental Self-Efficacy

This paper discusses the theoretical role of parental self-efficacy, or parents' beliefs in their competence and effectiveness in the parental role, as a mediator of relations between parent–child risk and parental sensitivity. Evidence is marshalled from studies of parenting in the contexts of maternal depression and child health risk to support the premise that parent–child characteristics affect parental sensitivity indirectly via their more direct impact on parental feelings of efficacy, and that parenting efficacy represents the ‘final common pathway’ in the prediction of parenting sensitivity. Also considered in this working model are specific social-contextual factors as independent contributors to parenting efficacy and as possible moderators of relations between parent–child characteristics and self-efficacy. Implications for intervention are discussed. © 1996 John Wiley & Sons, Ltd.     

Cultural Identity and the Expression of Depression: A Social Identity Perspective

The present research interrogates the greater tendency for Chinese people to somaticize depression relative to Westerners. Drawing from a social identity perspective, three studies were conducted examining the role that cultural norms play in symptom expression. In an initial study, we confirmed greater somatization, minimization of distress and suppression of emotional expression among Chinese participants compared with Australians (Study 1). Asian normative expectations of collectivism moderated these effects such that somatization was higher among those who endorsed collectivism norms, but only among Chinese participants. Studies 2a and 2b found that only when Asian participants identified strongly with Asian culture did collectivism norms predict somatic symptoms. These findings have implications for practitioners working with people from Asian cultures, highlighting that it is not culture per se, but the endorsement of normative expectations in the context of strong identification with cultural groups that predicts which symptoms of depression are emphasized. Copyright © 2016 John Wiley & Sons, Ltd.