Haloperidol-induced Mood and Retrieval of Happy and Unhappy Memories

The present study investigated the effect of haloperidol-induced mood in normal healthy male volunteers on the retrieval of memories of real-life personal experiences using a between-subjects double-blind design. Forty subjects were required to retrieve past real life experiences associated with a series of stimulus words following administration of a single oral dose of 5mg haloperidol or placebo. The experiences were subsequently rated by subjects for their happiness felt at the time of the original experience. A significant decline in self-reported hedonic tone was observed in subjects given haloperidol. In addition, subjects on placebo recalled a significantly greater percentage of happy memories than subjects who were on haloperidol; a trend for a reverse pattern was observed for unhappy memories. The effects of the drug on the retrieval of memories were only in part mediated by the decline in hedonic tone scores. The effects of haloperidol are interpreted in terms of drug-induced dysphoria.     

Diary reports on emotional experiences in the onset of a psychosocial transition: becoming drug‐free

The process of becoming drug free is viewed as a psychosocial transition in the life of drug addicts. A specific form of treatment of heroin addiction within residential communities is based on the importance of interpersonal relationships for change. Well‐being of 65 drug addicts during the first 2 weeks in a residential community is explored using a time‐sampling diary which was completed four times a day. The influence of subjects' history, situational context, and motive activation on well‐being and emotions is investigated. Results show that well‐being and emotions differ mainly according to subjects' history, but not — at least at the beginning of treatment within the community — according to situations. This is interpreted as a ‘state of shock’ in the new environment and highlights the necessity for special individual care for subjects with a long drug career. Copyright © 2001 John Wiley & Sons, Ltd.     

The rapid-smoking technique: Therapeutic effectiveness

The study examined the effectiveness of the rapid-smoking technique in terms of two measures of outcome—post-treatment abstinence rate and reduction in smoking achieved by non-abstinent subjects. A total of 75 volunteers (40 men and 35 women) participated in treatment and were randomly allocated to one of four conditions—rapid-smoking alone; rapid-smoking and relaxation training; rapid-smoking, relaxation and contingency contracting; or contingent rapid-smoking. No significant differences between treatment conditions were obtained. For the total sample, abstinence was achieved by 64% of the subjects immediately post-treatment but the probability of remaining abstinent 12 months later was only 0.33. Immediately post-treatment the non-abstinent subjects reduced their rate of cigarette consumption to 34.2% (SD = 29.3) of baseline smoking but by 12 months average consumption had increased to 82.4% (SD = 28.3) of baseline. It is concluded that rapid-smoking gives rise to substantial short-term changes in smoking behaviour but these effects are not sustained.     

Simple disturbance of the dam in the neonatal period can alter haloperidol-induced catalepsy in the adult offspring

Three experiments were performed to determine whether apparently minimal disturbances of dams and litters would influence haloperidol-induced akinesia. In Experiment I, Long-Evans hooded rats (a) were left unmanipulated, (b) received nestcage relocation and observation, (c) received nestcage relocation/observation and maternal separation, or (d) received nestcage relocation/observation and pup handling. The male adult offspring received open-field testing and later received forepaw-on-dowel catalepsy testing following saline, morphine (20 mg/kg), or haloperidol (2 mg/kg). In Experiment II, hooded rats received (a) no manipulation, (b) nestcage relocation, (c) maternal separation, or (d) pup handling. At weaning, dams were tested in the open-field. Activity wheel locomotion of the offspring was assessed following saline or haloperidol for 3 days/week for 3 weeks; then, 5 and 7 days later, rats received haloperidol (0.5 mg/kg) and catalepsy testing. In both experiments, manipulations involving the dam reduced the offsprings' haloperidol-induced catalepsy, but, in Experiment II, a history of haloperidol administration distinguished between the effects of nestcage relocation and maternal separation. In Experiment III, Swiss albino mice received (a) no treatment, (b) nestcage relocation and maternal separation, (c) relocation/separation and mild cold stress of pups, (d) relocation/separation and pup handling, or (e) relocation/separation and severe cold stress of pups. Adult male mice received saline or haloperidol (2.5 mg/kg) and inclined grid catalepsy testing. Mice receiving relocation/separation and mice receiving relocation/separation and severe cold stress showed enhanced catalepsy versus control mice. Thus, it was concluded that seemingly innocuous events in infancy can influence the intensity of extrapyramidal side effects of neuroleptics in adulthood.     

Polygraphic therapy control in Gilles de la Tourette syndrome--a case report

In a female patient with Gilles-de-la Tourette syndrome (GTS) the clinical improvement during drug therapy of haloperidol and clomipramine was proved with the help of a polygraphic method (simultaneous recording of different electrophysiological and vegetative parameters). Before intensifying therapy symptoms of vegetative irritation, motoric discharge patterns with high amplitude in correlation with movements and permanent activity with low amplitude even in a state of external motoric rest were found. After intensifying therapy vegetative stabilization and ceasing of any electrical activity in the EMG could be demonstrated. It is concluded that the effects of therapy in GTS may be checked and quantified by means of polygraphic methods.     

Sociability/impulsivity and attenuated dopaminergic arousal: critical flicker/fusion frequency and procedural learning

Two experiments examined the interaction of sociability (Soc) and impulsivity (Imp) components of extraversion and reduced dopamine activity (by haloperidol) on critical flicker/fusion frequency change scores (ACFFT) and procedural learning. In double-blind designs, subjects received either haloperidol (5 mg) or placebo; Soc and Imp were randomly sampled. In Experiment 1, Drug × Imp, and Drug × Imp × Soc interactions were found on ΔCFFT; in Experiment 2, a drug × Soc interaction was found on procedural learning. In both experiments, introverts seemed over-aroused under placebo (putatively due to the medical context), more optimally aroused under haloperidol; for procedural learning, extraverts seemed more optimally aroused under placebo, less optimally aroused under haloperidol. These data indicate that both Soc and Imp mediate the effects of arousal; Drug × Imp effects my conceal joint effects of Soc × Imp; and that Soc shows more consistent effects than Imp. These data complement a previous study of Soc/Imp and caffeine-induced arousal (Corr, Pickering & Gray, 1995), and lend support to H. J. Eysenck's (1967) arousal model of Extraversion.     

An 8-year study of multiple influences on drug use and drug use consequences

Multiple long-term influences on young adult drug use and abuse were tested within an interactionist perspective using latent-variable causal models. Intrapersonal influences included early drug use and social conformity. Proximal interpersonal influences were captured by perceived peer drug use, perceived adult drug use, and family disruption. More distal influences included perceptions of community approval or disapproval for drug use. Outcome measures included not only use of drugs but also disruptive drug use (getting high at work or school) and self-admitted problems with drugs. Data were obtained from 654 participants at three equally spaced time points during an 8-year longitudinal study that began when the subjects were in junior high school. Confirmatory factor analyses were used to test the adequacy of the hypothesized measurement model. Subsequently, a structural equation, or path model, was used to examine the across-time relations among the latent and manifest variables. Stability effects were found for all repeatedly measured latent variables across the 4-year spans. Social conformity strongly influenced other latent variables across time. Early drug use and perceived adult drug use were prominent predictors of young adult drug use, whereas prior drug use predicted disruptive drug use and a lack of social conformity predicted problems with drug use. Early adult alcohol use predicted later disruptive drug use and problems with drug use. Perceived adult drug use generally influenced later alcohol use, whereas peer drug use influenced later cannabis and hard-drug use. Implications for prevention and treatment using a multicausal interactionist perspective are discussed.     

Social factors influence haloperidol-induced catalepsy in rat

This study employed manipulations which presumably influence social interactions in rats: (1) paired housing with a heavier conspecific and (2) exposure to the odors of other rats. The dependent variable was the akinetic state induced by haloperidol, a neuroleptic and dopamine antagonist. In Experiment 1, adult male Long-Evans hooded rats were matched by weight and caged alone or in pairs with one rat 30 g heavier than its cagemate. All rats received haloperidol (1.5 mg/kg) and catalepsy testing. Heavy rats showed more catalepsy than the lighter member of pairs or weight-matched, singly housed controls. In Experiment 2, adult male rats were left unrecaged or were recaged into cages with bedding recently soiled by females or other adult males. After haloperidol (1.0 mg/kg), the rats exposed to bedding soiled by other adult males showed more catalepsy than did the control groups. Thus, the results of both experiments indicated that social factors can influence the akinesia induced by dopamine antagonists.     

Effects of haloperidol on schedule-induced polydipsia.

In dose-related amounts, the drug haloperidol attenuated schedule-induced drinking by rats prefed with 0.01-mg drug added to 0, 25, 50, 75 or all of 100 Noyes 45-mg pellets. Drug pellets also induced less drinking than did regular Noyes pellets by rats that obtained these pellets at 1-min intervals by bar pressing. Haloperidol also reduced bar pressing and, temporarily, rate of reinforcement. The results appeared not to be due to a general sedative effect of haloperidol but to its selective power to reduce angiotensin-induced drinking. Thus, schedule-induced drinking, which is abnormal in not causing satiation, is controllable by a drug that interferes with the renin-angiotensin hormone system thought to regulate normal drinking.     

Gender and height: Developmental patterns in knowledge and use of an accurate stereotype

The belief that men are taller than women is an accurate gender stereotype that is presumably learned through everyday encounters with men and women. It is unlike most gender beliefs that are difficult to quantify and verify, and that may be learned through means other than direct experience. This research makes use of several advantages available when studying an accurate stereotype (e.g., the ability to know the “truth” about judged targets). Subjects from five different age/grade levels (kindergarten, third grade, seventh grade, tenth grade, and college, N=491, 92.26% Caucasian, 7.54% Arabic, 0.2% African American) made judgments of “who is taller” among photographed male—female pairs that had actually been matched in height. Judgments were made of kindergarten, seventh grade, and college photo pairs. In a developmental context, height judgments are particularly interesting because the gender difference in height changes at different ages—specifically, girls are taller than boys around seventh grade. The data indicated that subjects were sensitive to the changing height stereotype—i.e., they judged adult males taller than adult females, but seventh grade females taller than seventh-grade males. However this was most strikingly true among subjects directly faced with this reality in their peer context—seventh graders—and among college students. Height judgments were also sensitive to an ingroup (gender) bias. The data are discussed in reference to the broader literature on stereotyping and base rate influences on judgment.     

Distinctiveness and the salience of social category memberships: Is there an automatic perceptual bias towards novelty?

It was hypothesized that the effects of novelty on social category membership salience may be mediated by perceivers' current tasks, rather than by an automatic perceptual bias (Taylor and Fiske, 1978). Subjects viewed tape-slide portrayals of mixed-sex groups (1 male—5 females, 2M—4F, 3M—3F, 4M—2F, 5M—1F) under ‘individual’ (focus on one target person) or ‘collective’ (focus on entire stimulus group) task conditions. Results on measures of sex stereotyping strongly supported the hypothesis, indicating that ‘individual’ task subjects tended to maximize stereotyping in the 1M—5F and 5M—1F conditions whilst ‘collective’ subjects did so in the 3M-3F condition. It is concluded that novel category memberships are not automatically prepotent in social perception, and the results are discussed in the context of a functional approach to the salience problem.     

Socializing Attribution: Generalization to “Real” Social Environments1

Social status variables have been shown to influence attributional judgments, but their effects have been demonstrated almost entirely in experimental settings. The influence of such statuses in experimental settings may differ from their influence in natural settings. We examined the influence on attributional judgments of the status characteristics of both subjects and actors in conjunction with variations in the degree of “real world” characteristics of both subjects and social context. These comparisons were drawn through a partial replication of earlier research investigating the effects of a social status variable, victim sex, and a situational variable—type of assault—on attributions about an assault victim. The social status characteristic, victim sex, had less influence on attributions in an adult juror sample than in a student sample and testimony-related characteristics were more influential in the adult juror sample than in the student sample. Thus, the categories of variables that influence attributions appear to depend on the context of judgment and on the breadth of subjects' life experience. These findings are discussed and we conclude with the caution that careful identification of the differences produced by context and subject characteristics is necessary to support generalization of laboratory-based research.     

Reaction time to letter name or letter case

Subjects were shown two letters from the set BDGbdg. In one condition, subjects were required to decide whether or not the letters had the same name. In the other condition, subjects decided whether or not the two letters were presented in the same case. Reaction times were always faster when the two letters on a given trial were physically identical. However, there was no difference in the speed of a name match or a case match when the two letters were not physically identical. Since subjects could have based a case match on the presence or absence of a single feature — a protruding vertical line — it was concluded that subjects are not able to selectively attend to a single visual feature in order to identify a letter. Rather, a subject analyzes several features in parallel in order to arrive at a simultaneous decision about a letter's name or case.     

Double dissociation of pharmacologically induced deficits in visual recognition and visual discrimination learning

Monkeys trained in either one-trial recognition at 8- to 10-min delays or multi-trial discrimination habits with 24-h intertrial intervals received systemic cholinergic and dopaminergic antagonists, scopolamine and haloperidol, respectively, in separate sessions. Recognition memory was impaired markedly by scopolamine but not at all by haloperidol, whereas habit formation was impaired markedly by haloperidol but only minimally by scopolamine. These differential drug effects point to differences in synaptic modification induced by the two neuromodulators that parallel the contrasting properties of the two types of learning, namely, fast acquisition but weak retention of memories versus slow acquisition but durable retention of habits.     

氟哌啶醇与丙咪嗪交互作用对成本效益决策的影响

本实验采用T迷宫延迟奖赏模型研究多巴胺D2受体拮抗剂氟哌啶醇和5-羟色胺重摄取抑制剂丙咪嗪的交互作用对成本效益决策的影响, 同时探讨了延迟时间对决策的影响。T迷宫两臂分别设置为低成本-低奖赏端和高成本-高奖赏端。实验结果发现：氟哌啶醇能够降低大鼠选择高成本-高奖赏端的次数, 丙咪嗪则能够增加大鼠选择高成本-高奖赏端的次数; 在同时注射这两种药物情况下, 丙咪嗪能够抑制由氟哌啶醇引起的对低成本-低奖赏端的选择倾向。另外, 实验发现, 随延迟时间的增加大鼠选择高成本-高奖赏端的次数相对减少。由此可见, 丙咪嗪能够反转由氟哌啶醇导致的对低成本-低奖赏端的选择倾向, 这可能是由于细胞间5-羟色胺含量的升高部分反转了由多巴胺系统受损导致的行为倾向; 延迟时间的改变可对决策倾向产生逆转, 因此成本的支出即延迟时间也是影响成本效益决策的重要因素。     

THE CONCEPT OF CORRELATION IN ADULTS

In the first of two experiments on the concept of correlation in adult subjects, the subjects' frequency estimates and inferences of relationship were studied relative to five different 2 × 2 distributions, each presented in a fixed sequence. In experiment II, the subjects' spontaneous strategies in subdividing and analyzing one 2 × 2 distribution were studied in a free situation. It is concluded that adult subjects with no statistical training apparently have no adequate concept of correlation (based on the ratio of the two pairs of diagonal frequencies), and that, in so far as they reason statistically at all, they tend to depend exclusively on the frequency of ++ cases in judging relationship. The need for studies involving ordinal scale and fully quantified variates is stressed.     

Low heart rate variability is not caused by typical neuroleptics in schizophrenia patients

Both elevated cardiovascular mortality and low cardio-vagal (parasympathetic) heart rate variability (HRV)--a risk factor for postmyocardial infarction--are reported in schizophrenia (SZ). Since a number of medications have strong effects of cardiac conductivity, we thought it important to examine if typical neuroleptic medications might also affect HRV. We examined cardiac vagal activity during both neuroleptic treatment and a drug-free condition in seven SZ patients who were participating in a pilot double-blind, crossover study of placebo and haloperidol treatment. Twenty-four-hour Holter electrocardiograms were analyzed for high frequency HRV, quantitated as the percent of successive normal interbeat intervals greater than 50 milliseconds (PNN50), which is a good index of parasympathetic cardiac modulation. The patients showed unchanged PNN50 (8.4+/-9.5 versus 8.3+/-10.5; t=.22, df=6, P=.5) between the haloperidol treatment and drug-free conditions. Despite the elapsed time, change in medication, and altered clinical state, the PNN50s were highly correlated (Spearman r=.98, P=.000). SAPS positive symptom scores declined with treatment from 12.8+/-6.5 to 8.5+/-3.5; paired t=3.26: df=6; P=.01. PNN50s were significantly associated with positive (r=-.86, df=6, P=.012) and negative symptom scores (r=-.87, df=6, P=.01). We found low cardiovagal modulation in medication-free SZ patients that was associated with core SZ symptoms and was unchanged by haloperidol and benztropine treatment. The reduced HRV in SZ patients at baseline may render them at greater cardiovascular risk than healthy subjects when treated with medications having strong cardiovascular effects.     

Effects of d-amphetamine on self-aggression and posturing in stumptail macaques

The behavioral effects of d-amphetamine sulfate were studied in adult male stumptail macaques living within a large heterogeneous group in an outdoor enclosure. Among five subjects that received a range of doses (.01 to .3 mg/kg), d-amphetamine increased self-aggressive behavior and abnormal posturing in subjects that exhibited these types of behavior prior to drug administration, but it had no effect in subjects not exhibiting those activities in the absence of the drug. For the former subjects, the dose-effect curves for self-aggression were of an inverted U-shape analogous to the effect of d-amphetamine on schedule-controlled behavior. Over the range of doses studied, the curve for abnormal posturing was monotonic. The data indicate that d-amphetamine can have effects on untrained behavior in individual animals in a quasinatural environment that are qualitatively and quantitatively similar to the behavioral effects observed in other laboratory environments, and that d-amphetamine does not evoke or increase a behavioral response in individual subjects that do not exhibit the response in the absence of the drug.     

Chick vocalization and emotional behavior influenced by apomorphine

For the purpose of studying the role of dopamine (DA) in the causation of vocalization and other behavior in domestic chicks, 5-day-old birds were injected with 1 mg/kg doses of apomorphine hydrochloride, and their behavior was recorded by methods of direct observation. The effects of the drug on birds with bilateral lesions of the intercollicular nucleus (a vocal area) and on birds pretreated with the DA antagonists pimozide and haloperidol were also examined. In intact chicks, apomorphine induced trills, facilitated twitters, and inhibited warbles. Pecking at conspicuous objects in the cage and locomotion were increased, whereas the duration of eye closure was reduced. In chicks with lesions there was no facilitation of trills, twitters, or pecking, whereas the other drug-induced behavioral effects were as in intact chicks. Dopamine antagonists blocked the trills and twitters facilitated by apomorphine but did not protect against the inhibition of warbles. It is concluded that trills, twitters, and pecking are produced by activation of dopaminergic mechanisms. It is hypothesized that some of the behavior induced by apomorphine, especially vocalization and pecking, are a consequence of altered states of attention induced by the drug.     

Diagnosing,Conceptualizing, and Treating Eating Disorders Not Otherwise Specified: A Comprehensive Practice Model

This article presents research and evidence‐based practices for identifying, understanding, diagnosing, conceptualizing, and providing a continuum of treatment for the most commonly experienced types of eating‐related counseling concerns—namely, eating disorders not otherwise specified—among the population most likely to present these types of needs: adolescent girls and young adult and adult women.