Experience of stress in childhood negatively correlates with plasma oxytocin concentration in adult men

Early life experience is known to affect responses to stress in adulthood. Adverse experience in childhood and/or adolescence sensitises to life events that precipitate depression in later life. Published evidence suggests a relationship between depression and oxytocin (OT), but the extent to which early life experience influences OT disposition in adulthood deserves further exploration. This study hypothesised that early life stress (ELS) has a long-term negative effect on OT system activity. The study was performed on 90 male volunteers (18-56 years; mean ± standard deviation = 27.7 ± 7.09 years). Several questionnaires were used to assess: health, early life stressful experiences in childhood (ELS-C, up to 12 years) and early life stressful adolescence (13-18 years), recent stressful life events, depressive symptoms, state-trait anxiety and social desirability. Plasma OT concentration was estimated by means of a competitive enzyme immunoassay. Lower OT concentrations were significantly associated with higher levels of ELS-C (p < 0.01), and with depressive symptoms and trait anxiety (both p < 0.05). The interaction between ELS-C and trait anxiety was significant (p < 0.05), indicating that the link between ELS-C and plasma OT concentration is moderated by trait anxiety. These results contribute to the evidence that early life adverse experience is negatively associated with OT system activity in adulthood, and offer further insight into mediator and moderator effects on this link.     

Changes in Neuroticism Following Trauma Exposure

Using longitudinal data, the present study examined change in midlife neuroticism following trauma exposure. Our primary analyses included 670 participants (M_age = 60.55; 65.22% male, 99.70% Caucasian) who completed the NEO Personality Inventory at ages 42 and 50 and reported their lifetime exposure to traumatic events approximately 10 years later. No differences in pre‐ and post‐trauma neuroticism scores were found among individuals who experienced all of their lifetime traumas in the interval between the personality assessments. Results were instead consistent with normative age‐related declines in neuroticism throughout adulthood. Furthermore, longitudinal changes in neuroticism scores did not differ between individuals with and without histories of midlife trauma exposure. Examination of change in neuroticism following life‐threatening traumas yielded a comparable pattern of results. Analysis of facet‐level scores largely replicated findings from the domain scores. Overall, our findings suggest that neuroticism does not reliably change following exposure to traumatic events in middle adulthood. Supplemental analyses indicated that individuals exposed to life‐threatening traumas in childhood or adolescence reported higher midlife neuroticism than individuals who experienced severe traumas in adulthood. Life‐threatening traumatic events encountered early in life may have a more pronounced impact on adulthood personality than recent traumatic events.     

Negative life events and symptoms of depression and anxiety: stress causation and/or stress generation

Background and Objectives: Stressful life events are known to contribute to development of depression; however, it is possible this link is bidirectional. The present study examined whether such stress generation effects are greater than the effects of stressful life events on depression, and whether stress generation is also evident with anxiety. Design: Participants were two large age cohorts (N = 732 aged 44 years; N = 705 aged 63 years) from the West of Scotland Twenty-07 study. Methods: Stressful life events, depression, and anxiety symptoms were measured twice five years apart. Cross-lagged panel analysis examined the mutual influences of stressful life events on depression and on anxiety over time. Results: Life events predicted later depressive symptomatology (p = .01), but the depression predicting life events relationship was less strong (p = .06), whereas earlier anxiety predicted life events five years later (p = .001). There was evidence of sex differences in the extent to which life events predicted later anxiety. Conclusions: This study provides evidence of stress causation for depression and weaker evidence for stress generation. In contrast, there was strong evidence of stress generation for anxiety but weaker evidence for stress causation, and that differed for men and women.     

Childhood Sexual Abuse and Revictimization In Adolescence and Adulthood

Abstract

Childhood sexual abuse must be seen as a pervasive risk factor in children's lives: No demographic or family characteristics have as yet been identified to rule out the possibility that a child will be or has been sexually abused (Finkelhor, 1993). The adverse consequences of sexual abuse, both immediate and long term, have been documented by a large body of research. After a summary of the main findings from this research, the main objective of the present chapter is to examine the impact of childhood sexual abuse on a particular aspect of psychological functioning: the development of sexual behavior and sexual relationships. In this analysis, special consideration is given to the question of whether individuals who were sexually abused as children are at greater risk of experiencing sexual victimization in later life than individuals without experience of abuse. This question has generated a substantial body of evidence (see Messman & Long, 1996, for a review), and researchers are beginning to understand pathways from the experience of abuse in childhood to revictimization in adolescence and adulthood.     

Pathways maintaining physical health problems from childhood to young adulthood: The role of stress and mood

Objective: Poor physical health in childhood is associated with a variety of negative health-related outcomes in adulthood. Psychosocial pathways contributing to the maintenance of physical health problems from childhood to young adulthood remain largely unexamined, despite evidence that factors such as negative mood and stress impact physical health.

Design: The current study tested the direct and indirect effects of ongoing health, chronic stress, health-related chronic stress, and depressive symptoms at age 20 on the link between health problems in childhood and young adulthood (age 21) in a longitudinal sample (n = 384).

Main Outcome Measures: The hypotheses were tested using a multiple mediation path analysis framework; the primary outcome measure was a composite index of health status markers in young adulthood.

Results: The proposed model provided an adequate fit for the data, with significant total indirect effects of the four mediators and significant specific indirect effects of health-related chronic stress and depressive symptoms in maintaining health problems from childhood into young adulthood.

Conclusions: Health problems are maintained from early childhood into young adulthood in part through psychosocial mechanisms. Depressive symptoms and health-related chronic stress have significant, unique effects on the relationship between health problems in early childhood and young adulthood.     

Exposure to the Chinese famine in early life and depression in adulthood

We aimed to investigate whether exposure to the Chinese famine (1959–1961) in early life was associated with depression in adulthood. We included 17,505 participants from the China health and retirement longitudinal study (CHARLS). Participants were classified into indirect and direct exposure groups. And the directly exposure groups including prenatal, childhood, adolescence/adult exposure groups. Depression was diagnosed by Center for Epidemiological Studies Depression Scale-10 (CES-D) score. Multivariate logistic regression model was used to calculate the odd ratios (ORs) and 95% confidence intervals (CIs) of depression. In women, prenatal, childhood, adolescence/adult exposure groups had higher depression risk than indirect exposure group (OR = 1.46, 1.40, and 1.67, respectively). However, there was no significant association between famine exposure and depression among men. Exposure to famine during prenatal (OR: 1.48; 95% CI: 1.07–2.06), childhood (OR: 1.47; 95% CI: 1.13–1.91), and adolescence/adult (OR: 1.63; 95% CI: 1.24–2.15) period were associated with depression among subjects living in rural, but not those living in urban. Exposure to the Chinese famine in early life had sex and area-specific associations with depression.     

Sex segregation in friendships and normative contexts across the life span

Sex segregation (the separation of boys and girls into same-sex groups in their friendships and casual encounters; [Thorne, B., & Luria, Z. (1986). Sexuality and gender in children’s daily worlds. Social Problems, 33, 176–190]), has typically been viewed as a childhood phenomenon. In the present paper, we review research that suggests the phenomenon of sex segregation persists across the life span. We draw from a social-constructionist model to synthesize literature documenting sex segregation in friendships and aspects of individuals’ socio-cultural contexts in childhood, adolescence, and early and later adulthood. We consider developmental continuities in mechanisms that may be associated with sex segregation, including behavioral compatibility, communication styles, third-party resistance to other-sex relationships, and institutional barriers to other-sex relationships. We discuss how these factors may, through a reciprocal process, contribute to and result from sex segregation. Finally, we offer recommendations for future research.     

Retrospective coping strategies during sexual identity formation and current biopsychosocial stress

Background: Lesbian, gay men, and bisexual individuals (LGBs) often experience distress related to the recognition, self-acceptance, and disclosure of their sexual orientation. Objectives and Design: Retrospectively reported coping strategies enacted during sexual identity formation among LGBs were assessed in relation to current stress indices measured using environmental (frequency of perceived daily hassles), psychological (perceived distress), and biological (allostatic load [AL] levels representing physiological dysregulations) perspectives. Methods: Forty-six healthy LGBs between the ages of 18 and 45 (M = 23.91, SE = .80) participated. Questionnaires included the Ways of Coping Checklist adapted to disclosure milestones, Daily Hassles Inventory, and Perceived Stress Scale. AL was calculated using 21 biomarkers of neuroendocrine, immune, cardiovascular, and metabolic functioning. Results: Avoidance coping during sexual identity formation was positively associated with frequency of daily hassles (β = .598, p < .001), perceived stress (β = .361, p = .015), and AL (β = .405, p = .006). By contrast, seeking social support was negatively associated with perceived stress (β = –.598, p = .048). Conclusions: Emotion-focused coping strategies during LGB sexual identity development are associated with current indices of biopsychosocial stress.     

Evidence for a sensitive period in the effects of early life stress on hippocampal volume

Exposure to stress has been causally linked to changes in hippocampal volume (HV). Given that the hippocampus undergoes rapid changes in the first years of life, stressful experiences during this period may be particularly important in understanding individual differences in the development of the hippocampus. One hundred seventy‐eight early adolescents (ages 9–13 years; 43% male) were interviewed regarding exposure to and age of onset of experiences of stress; the severity of each stressful event was rated by an objective panel. All participants underwent structural magnetic resonance imaging, from which HVs were automatically segmented. Without considering the age of onset for stressful experiences, there was a small but statistically significant negative association of stress severity with bilateral HV. When considering the age of onset, there was a moderate and significant negative association between stress severity during early childhood (through 5 years of age) and HV; there was no association between stress severity during later childhood (age 6 years and older) and HV. We provide evidence of a sensitive period through 5 years of age for the effects of life stress on HV in adolescence. It will be important in future research to elucidate how reduced HV stemming from early life stress may contribute to stress‐related health outcomes.     

The relation between infant freezing and the development of internalizing symptoms in adolescence: A prospective longitudinal study

Given the long‐lasting detrimental effects of internalizing symptoms, there is great need for detecting early risk markers. One promising marker is freezing behavior. Whereas initial freezing reactions are essential for coping with threat, prolonged freezing has been associated with internalizing psychopathology. However, it remains unknown whether early life alterations in freezing reactions predict changes in internalizing symptoms during adolescent development. In a longitudinal study (N = 116), we tested prospectively whether observed freezing in infancy predicted the development of internalizing symptoms from childhood through late adolescence (until age 17). Both longer and absent infant freezing behavior during a standard challenge (robot‐confrontation task) were associated with internalizing symptoms in adolescence. Specifically, absent infant freezing predicted a relative increase in internalizing symptoms consistently across development from relatively low symptom levels in childhood to relatively high levels in late adolescence. Longer infant freezing also predicted a relative increase in internalizing symptoms, but only up until early adolescence. This latter effect was moderated by peer stress and was followed by a later decrease in internalizing symptoms. The findings suggest that early deviations in defensive freezing responses signal risk for internalizing symptoms and may constitute important markers in future stress vulnerability and resilience studies.     

Social predictors of unsuccessful entrance into the labour market—A socialization process perspective

Social determinants over the life course, including childhood family characteristics, were studied in predicting unsuccessful entrance into the labour market at the age of 31 years. Among men, unsuccessful entrance into the labour market was predicted prospectively by the mother's receptive attitude towards receiving social aid and contentment with existing circumstances in early childhood, the family's low social status in adolescence, and low vocational education in early adulthood. Among women, it was predicted prospectively by low school attainment in adolescence and low vocational education in early adulthood, and associated cross-sectionally with having more than two children. Among both genders having a low income, poor subjective health and poor life satisfaction, as well as receiving little social support associated with unsuccessful entrance into the labour market. The results emphasize the role of childhood social factors in preventing long-term unemployment in young adulthood.     

Gender Differences in Depression

From early adolescence through adulthood, women are twice as likely as men to experience depression. Many different explanations for this gender difference in depression have been offered, but none seems to fully explain it. Recent research has focused on gender differences in stress responses, and in exposure to certain stressors. I review this research and describe how gender differences in stress experiences and stress reactivity may interact to create women's greater vulnerability to depression.     

The relationship between early life stress and working memory in adulthood: A systematic review and meta-analysis

ABSTRACT

Exposure to early life stress has been linked to impairment in cognitive functioning in adulthood. The aim of this study was to systematically review the literature on the relationship between early life stress and working memory, a central component of cognitive functioning. Database searches yielded 358 abstracts matching the search terms. Abstract screening followed by full-text review resulted in 26 publications suitable for inclusion, of which 23 were included in the meta-analysis. Results of the meta-analysis suggested exposure to early life stress was associated with poorer working memory. Even though there were a wide variety of working memory tasks used, this effect was significant for both phonological and visuospatial working memory tasks, and both visual and aural task presentation modalities. The effect was also found in samples with and without clinical psychopathology. This review provides recommendations for future research and implications for clinical practice.     

Hiding in plain sight: Older U.S. purpose exemplars

ABSTRACT

Despite significant research on purpose in adolescence and early adulthood, little is known about purpose in older adults. This paper defines purpose as ongoing commitment to and sustained action toward goals that are meaningful to the self and aim to contribute beyond the self. This study of purpose in later life draws on interviews of 102 respondents drawn from a U.S. nationally representative sample of 1198 men and women aged 50–92. Eighteen interviewees are identified as exemplars of purpose beyond the self and are matched with a comparison group of non-purposeful peers. Interview coding revealed that, in contrast to the non-purposeful comparison group, the purpose exemplars describe their lives as including several interconnected sources of well-being: purpose beyond the self, positive relationships, positive life engagement, a sense of competence, and freedom balanced with the desire to contribute. Implications for practitioners and the public are discussed.     

Childhood exposure to emotional abuse and later life stress among Kenyan women: a mediation analysis of cross-sectional data

Background and objective: We explore whether perceived stress among Kenyan mothers is predicted by childhood exposure to emotional abuse – both witnessed among parents and experienced directly. Further, we explore whether this association is mediated by social support, family functioning and polygynous marriage.

Design: We used cross-sectional data from a systematic random sample (n?=?1974) of mothers in semi-rural Kenya.

Methods: Data were collected using validated scales and trained interviewers. Analyses were conducted using bootstrapped structural equation models and fixed-effects linear regression models, controlling for age and household wealth.

Results: Reported experience of emotional abuse – both directly experienced and observed among household adults – was high in the present population (72.5% and 69%, respectively). Perceived stress among women was significantly higher if they were exposed to more emotional abuse during childhood (p?<?.001). Lower social support, worse family functioning and higher rates of polygynous marriage mediated pathways between emotional abuse exposure during childhood and adult perceived stress.

Conclusion: Future research should investigate whether social integration, identity formation and self-esteem underlie observed dynamics in sub-Saharan Africa. Efforts to promote social integration and support should target children currently experiencing emotional abuse, and may include child-targeted high quality television programing and adult-targeted media and celebrity campaigns.     

Continuity and change in personality traits from adolescence to midlife: a 25-year longitudinal study comparing representative and adjudicated men

In the first study, a hierarchical structure of personality traits was identified using data from a longitudinal study tracing two samples of men from adolescence to midlife (i.e., a representative sample of the general population and a sample of individuals adjudicated during their adolescence). The second study examined structural, rank-order, and mean-level continuity. Partial structural continuity was demonstrated through confirmatory factor analysis. Regarding rank-order continuity, the correlations were stronger as age increased, particularly for the adjudicated men. For mean-level continuity, the adjudicated men displayed higher scores from adolescence to midlife for nearly every personality trait related to Disinhibition and Negative Emotionality. Significant decreases were observed in these traits for both samples, supporting the hypothesis of a normative psychological maturation. Although both samples showed this maturation, the adjudicated men displayed a lower rate of change during adolescence and early adulthood. The two samples did not differ in Extraversion and this trait remained more stable, particularly for adjudicated men.     

Emotional suppression explains the link between early life stress and plasma oxytocin

Early life stress (ELS) has been found to be associated with lower concentrations of plasma oxytocin (OT) in adulthood. It is not yet clear, however, what mechanisms underlie this association. The goal of the present study was to test the role of emotional suppression as an intervening variable between ELS in childhood and plasma OT. In a nonclinical sample of 90 men, ELS, emotional suppression, and plasma OT were assessed. Emotional suppression was positively associated with ELS (r = 0.37, p < 0.001) and negatively associated with plasma OT concentrations (r = ?0.30, p < 0.01). In contrast, cognitive reappraisal – an alternative emotion regulation strategy – was not correlated with ELS or plasma OT concentrations. Cross-sectional regression analyses revealed that the ELS explained variance in plasma OT via emotional suppression. Moderation analyses revealed that the combination of high ELS and high emotional suppression was associated with the lowest concentrations of plasma oxytocin. These findings are consistent with the view that emotional suppression may be one pathway linking ELS and OT.     

Paths to Late Midlife Well-Being for Women and Men: The Importance of Identity Development and Social Role Quality

Theories of adult development suggest that personality development and social role involvements are sources of adult well-being for both men and women. However, previous research on this topic has focused mainly on (a) women, and (b) early stages of adulthood. We tested an alternative model for predicting late-midlife adults’ well-being, with role quality, number of roles, and healthy adaptation to late midlife (reflected in lower concern about aging) as mediators of the relationship between young adult identity development and well-being in late midlife. Results indicated that the model fit women’s experience very well, and men’s experience somewhat. Follow-up analyses indicated that the model fit men’s experience with respect to family role quality, but that young adult identity played a lesser role in men’s well-being in later midlife, and that problems in the late-midlife work role were reflected in concerns about aging for men, but not for women.     

Positive and problematic support,stress and quality of life in patients with systemic lupus erythematosus

Background and Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Previous studies showed that perceived social support has an important role in enhancing patient's quality of life (QOL). However, the precise mechanisms through which social support exerts such an effect are not completely understood. The aim of this paper is to test two alternative models explaining the relationship between social support (positive and problematic) and two dimensions of QOL: Health-Related (HR-QOL) and Non-Health-Related (NHR-QOL). Design: Model A (mediation) hypothesized that positive support would reduce stress while problematic support would increase stress), and that this in turn would reduce QOL. Model B (moderation) hypothesized that the effect of support on QOL would be moderated by the experience of stress in that more stressed individuals would show stronger effects. Methods: Three hundred and forty-four Italian patients with SLE completed an online questionnaire. Results: Stress partially mediated the relationship between support and QOL dimensions (either HR-QOL and NHR-QOL) thus supporting Model B. As hypothesized, positive support reduced stress, while problematic support increased stress. Conclusions: These findings help to explain the complex relationship between social support, stress and QOL in patients with SLE.     

The Role of Career Aspiration,Self-Esteem,Body Esteem,and Gender in Predicting Sense of Well-being Among Emerging Adults

During emerging adulthood, one’s sense of well-being undergoes many rapid changes. Although emerging adults often present considerable energy, creativity, and hopefulness, both in higher education classrooms and workplaces, they often experience a decrease in well-being due to experience confusion, stress encounters, and difficulties in transitioning to adulthood. The authors examined four noteworthy key socioemotional factors that may be linked to emerging adults' sense of well-being: career aspiration, self-esteem, body esteem, and gender. Three hundred 20- to 29-year-old university students participated in the study. Results showed that well-being was correlated positively with self-esteem and body esteem, and body esteem was correlated negatively with gender (men scored higher). Regression analyses revealed that for both men and women, self-esteem and body esteem predicted well-being. Nevertheless, when the gender was analyzed separately, career aspiration predicted well-being only for men, whereas body esteem predicted well-being only for women. The study findings illuminates the importance of generating preventive measures in childhood and adolescence, through reinforcing skills such as resilience and self-esteem with the aim of passing through emerging adulthood with as little harm as possible to the sense of well-being.