以兔抗鼠淋巴细胞血清为非条件刺激的条件性免疫抑制

采用一种生物类免疫抑制剂-兔抗鼠淋巴血清（rabbit anti-rat lymphocyte serum,ALS）为非条件刺激（UCS）,糖精水为条件刺激（CS）,以双瓶给水法置于鼠笼前端饮用偏好侧。在一次性CS-UCS结合训练后,单独再次给予CS,使卵清蛋白（OVA）免疫过的大鼠表现出脾淋巴细胞对有丝分裂原PWM的增殖反应降低,血抗OVA抗体的总量及脾内抗OVA抗体生成细胞的减少,但动物未表现出条件性味觉厌恶的行为反应。这些结果表明条件性免疫抑制与味觉厌恶行为条件反射没有必然联系,并非是厌恶行为反应或情绪应激的伴随产物。UCS也并非必需具有感觉的毒副作用,条件性免疫抑制是脑高级神经活动调节免疫功能的结果。     

The effects of preexposure-test and conditioning-test intervals on the magnitude of latent inhibition

Using the conditioned taste aversion paradigm, two experiments were conducted to examine the effects of the interval between preexposure and test and that between conditioning and test on the magnitude of latent inhibition. Experiment 1 revealed that the degree of latent inhibition was attenuated when rats were given a 21‐day interval between preexposure and test. It was also found that this attenuation was more marked in subjects which were given conditioning immediately after preexposure than those which were conditioned shortly before the test. Retention interval between preexposure and test was reduced to 12 days in Experiment 2, and exactly the same pattern of results as those found in Experiment 1 was obtained. These findings suggest that the memory of conditioning as well as that of preexposure decreases its retrievability after a long retention interval, although the former is more retainable than the latter.     

Conditioned taste aversion is enhanced when the unconditioned stimulus is presented in a different context

Using a conditioned taste aversion procedure with rats as the subjects, two experiments examined the effect of presenting a conditioned stimulus (CS saccharin solution) in one context followed by an unconditioned stimulus (US LiCl) in a different context. Experiment 1 showed that animals which received the above-mentioned procedure (Group D) showed a more marked conditioned aversion to the CS than animals which were given both the CS and the US in the same context (Group S). Experiment 2 found that in both Group D and Group S, aversion to the CS increased when the subjects were exposed to the conditioned context after the conditioning. These findings supported the argument that the strength of the CS-US association acquired during conditioning is compared with that of the context-US to determine the magnitude of aversion revealed to the CS.     

Distractor effect on the latent inhibition of conditioned flavor aversion in rats

Using a conditioned flavor aversion procedure with rats as subjects, the effect of the addition of a distractor stimulus on the magnitude of the latent inhibition effect was examined. Experiment 1 showed that latent inhibition to vinegar was attenuated by the addition of sucrose during preexposure. On the other hand, sucrose added during conditioning to vinegar did not attenuate latent inhibition. It was also found that the degree of latent inhibition to the vinegar-sucrose compound solution was less when vinegar alone was preexposed (i.e., when sucrose was added only during conditioning) than when the compound solution was preexposed (i.e., when sucrose was added both during preexposure and during conditioning). Experiment 2 gave similar results but with sucrose assigned as the target flavor and vinegar as the distractor. These findings are in full agreement with the generalization decrement account of latent inhibition.     

Facilitation of Sodium Aversion Learning in Sodium-Deprived Rats

Two experiments with rats explored the effects of sodium deprivation induced by furosemide injections upon acquisition of taste aversion to sodium chloride (NaCl). In Experiment 1, rats under either sodium deprivation or a balanced nutrition condition were given access to a limited amount of NaCl solution prior to poisoning. When all rats were tested under sodium repletion, the previously sodium-deprived rats consumed less NaCl than did the nondeprived rats. This finding was replicated in Experiment 2A in which ingestion of a compound solution of NaCl and hydrochloric acid (HCl) was followed by poisoning. Consumption of HCl, however, showed the opposite pattern: the sodium-deprived rats drank more HCl than did the nondeprived rats, a result that was replicated in Experiment 2B. These results suggest that sodium deprivation strengthens the salience of NaCl, thereby facilitating acquisition of aversion to this taste and strongly overshadowing that to a simultaneously presented taste.     

Drug discrimination using a conditioned taste-aversion paradigm in rhesus monkeys.

The development of drug discrimination was assessed in rhesus monkeys using the conditioned taste-aversion paradigm. Monkeys were initially trained to respond under a fixed-ratio 30-response schedule of food-pellet delivery to assess the rate-decreasing effects of alprazolam (0.03 to 3 mg/kg, i.m., 60 min presession). Alprazolam decreased responding at doses greater than 0.1 mg/kg. Discriminative stimulus effects of alprazolam were then assessed by giving 0.03 mg/kg before sessions in which 1.8 mEq/kg lithium chloride was given immediately after the session (alprazolam/lithium session). On intervening days, saline was given before and after the session (saline/saline session). Rates of responding decreased over successive alprazolam/lithium sessions and also during the saline/saline session that immediately followed an alprazolam/lithium session. During subsequent saline/saline sessions, rates of responding returned to levels near baseline rates within two to four sessions. The discriminative stimulus effects of alprazolam were then assessed by giving 0.1 mg/kg before sessions in which 1 mg/kg d-amphetamine was given immediately after the session (alprazolam/d-amphetamine session). Rates of responding decreased during subsequent alprazolam/d-amphetamine sessions in drug-experienced monkeys, but did not decrease during intervening saline/saline sessions. These findings demonstrate that drug stimuli associated with postsession drug injections can rapidly develop control over behavior and suggest that similar methods be explored in the assessment of drug discrimination.     

企业员工行为中庸化的特征分析

本研究采用了问卷调查法,对苏州271名企业员工的行为中庸化的特征进行了研究。结果表明：（1）企业员工的行为,总体上是趋向于中庸的;（2）男性员工较女性员工在行为上更倾向于中庸;（3）教育水平高的员工较教育水平低的员工更倾向于中庸;（4）职务水平高的员工较职务水平低的员工更倾向于中庸;（5）企业性质不同、资本来源不同的企业员工,其行为中庸化水平不同。     

Conditioned ethanol aversion in rats induced by voluntary wheel running,forced swimming,and electric shock: An implication for aversion therapy of alcoholism

This study was planned to demonstrate rats’ acquisition of aversion to ethanol solution consumed before voluntary running, forced swimming, or electric shock delivery. Wistar rats under water deprivation were allotted to four groups of eight rats each, and all rats were allowed to drink 5% ethanol solution for 15 min. Immediately after the ethanol drinking, rats of Group Run were put into the individual running wheels for 15 min, those of Group Swim were put into the individual swimming pools for 15 min, those of Group Shock received electric shocks for 15 min (15 0.45-mA shocks of 0.7s with the intershock interval of 1 min) in the individual small chambers, and those of Group Control were directly returned back to the home cages. This procedure was repeated for six days, followed by a two-day choice test of ethanol aversion where a bottle containing 5% ethanol solution and a bottle of tap water were simultaneously presented for 15 min. In the test, Groups Run, Swim, and Shock drank ethanol solution significantly less than tap water, while Group Control drank both fluids equally. The effects of running, swimming, and shock were equivalent. The successful demonstration of acquired ethanol aversion induced by exercise (running and swimming) or shock in rats suggests an avenue for clinical application of exercise and shock treatments for human alcoholics, though there are many issues to be resolved before the practical use.     

The Effect of Negative Incentives in Serial Learning: VII. Theory of Punishment

Eighty three-, four-, five-, and six-year-old boys and girls were presented with experimental conditions where context, transformational complexity, and verbal cue were varied, Two experimental tasks, a perceptually Concrete and an Abstract task, were included and Ss were assigned to a Verbal Cue or a Nonverbal Cue condition. All Ss responded to both the present progressive and the past tenses. Results revealed significant effects of the Age and Tense factors, and improved performance on Comprehension over Production. Younger children made fewer overall errors than older ones. Ss performed better on the present progressive than on the past tense on the perceptually Concrete task, while the reverse was true on the Abstract task. These findings demonstrate that language performance is the result of a complex interrelationship between transformational complexity and the perceptual properties of linguistic structures.     

论儒家全球伦理金律

“儒家全球伦理金律”是儒家思想内所包含的或从中发展出的能够作为全人类共同遵守奉行的基本的伦理原则、价值观和行为规范。它可初步归纳为“十大金律”,其特点为普适性、基础性、悠久性、系统性、针对性、智慧性和简洁性,它的本质是人道主义、合理主义与和平主义。全球伦理的构建不能缺少儒家伦理,儒家全球伦理是中华民族文化对人类文明作出的独特贡献。     

The role of the insular cortex in taste function

In spite of over 30 years of research, the role of the Insular Cortex (IC) in taste memory still remains elusive. To study the role of the IC in taste memory, we used conditioned taste aversion (CTA) for two different concentrations of saccharin; 0.1% which is highly preferred, and 0.5% which is non-preferred. Rats that had been IC lesioned bilaterally with ibotenic acid (15 mg/ml) before CTA showed significant learning impairments for saccharin 0.1% but not for saccharin 0.5%. To test CTA memory retention, rats lesioned a week after CTA training became completely amnesic for saccharin 0.1% yet only mildly impaired for saccharin 0.5%. Interestingly, the resulting preference for either concentration matched that of IC lesioned animals when exposed to either saccharin solution for the first time, but not those of sham animals, implying that IC lesions after CTA for either saccharin solution rendered complete amnesia, irrespective of the original preference. Our data indicate that an intact IC is essential for CTA learning and retention, as well as for an early neophobic response, but not for taste preference itself. Our data supports a model where the IC is involved in general taste rejection.     

Effect of exposure to lithium-paired or amphetamine-paired saccharin solution on open arm avoidance in an elevated plus maze

Recent evidence suggests that drug-induced conditioned taste avoidance may be mediated by conditioned fear (e.g., Parker, 2003). The experiments reported here evaluated the effect of exposure to a drug-paired flavor on open arm exploration in an elevated plus maze (EPM), a measure of fear. When rats were tested on a familiar (trial 2) EPM, but not on a novel (trial 1) EPM, prior exposure to a lithium-paired saccharin solution enhanced open arm activity relative to saline-paired saccharin. On the other hand, when rats were exposed to lithium-paired saccharin during plus maze exposure, they displayed suppressed open arm activity relative to unpaired controls when tested in a familiar maze. The pattern of results was specific to the conditional affective properties of the taste, because exposure to unconditional sickness produced by administration of lithium, and unconditionally unpalatable quinine solution did not produce this pattern. These results were interpreted in terms of the opponent process model of motivation; that is, exposure to a lithium-paired flavor elicits conditioned fear which is immediately followed by conditioned relief when the exposure is terminated. On the other hand, exposure to an amphetamine-paired flavor either before or during EPM testing enhanced open arm exploration. Since the strength of taste avoidance did not differ among amphetamine and lithium conditioned rats, these results provide further evidence that the nature of a saccharin-lithium association differs from that of a saccharin-amphetamine association.     

邻近效应对多媒体学习中图文整合的影响:线索的作用

在多媒体学习中图文排列的邻近或远离会影响学习的效果。本研究操纵了多媒体呈现的图文排列位置,采用颜色作为线索引导注意,探讨了线索有无和图片-文字的空间位置对多媒体学习图文整合的影响。结果发现:图文邻近呈现时的保持测验和迁移测验成绩好于图文远离呈现,图文邻近呈现时学习者对关键兴趣区的进出次数更多,体现出以文字为导向的阅读模式。线索并没有单独影响学习成绩和注意分配;但结合图文位置后,发现有线索时图文邻近学习材料的注视次数、进出关键兴趣区的次数显著多于图文远离。研究认为:图文的邻近效应不仅提高学习者对知识的识记和理解,同时也影响了学习者的注意分配过程,图文邻近呈现有助于图片和文本信息的注意联结和知识整合;线索能使邻近效应得到凸显,更好地促进图文信息的注视加工,但没有改进学习的效果。     

内隐学习在第二语言语音学习中的作用

本研究以大学生为被试,用符合德语读音规则的人造无意义单词(含4~5个音素)为刺激材料,采用强分离程序———匹配和编辑,并增设时间变量,比较了在先匹配后编辑,先编辑后匹配,只匹配,只编辑4种不同内隐、外显学习方式下被试对语音规则的掌握。结果表明,语音学习中存在内隐学习的优势效应,内隐与外显结合的学习方式最好。此外,实验证实了语音的内隐学习也存在长时效应。     

Burying by rats in response to aversive and nonaversive stimuli

Previous investigations have shown that rats bury a variety of conditioned and unconditioned aversive stimuli. Such burying has been considered as a species-typical defensive reaction. In the present studies, rats buried spouts filled with Tabasco sauce, or condensed milk to which a taste aversion was conditioned, but did not bury water-filled spouts or spouts filled with a palatable novel food (apple juice) to which a taste aversion was not conditioned. However, in other experiments rats consistently and repeatedly buried Purina Rat Chow, Purina Rat Chow coated with quinine, and glass marbles. This indicates that a variety of stimuli, not all aversive or novel, evoke burying by rats. Whereas the behavior may reasonably be considered as a species-typical defensive behavior in some situations, the wide range of conditions that occasion burying suggests that the behavior has no single biological function.     

简单心算中数学学习困难儿童的数字距离效应

采用事件相关电位(ERP)方法,以阿拉伯数字的简单心算为任务,考察数学学习困难儿童(MD)的数字距离效应。行为数据的结果表明:MD组没有出现数字距离效应,对照组儿童出现了数字距离效应。事件相关电位数据显示:与对照组相比,MD组N270的潜伏期更长;两组被试在N270的波幅和潜伏期上都没有表现出数字距离效应。研究结果表明:MD儿童对数量信息的空间表征存在缺陷。     

关于人工语法学习迁移效应的一项实验研究

本研究探讨了人工语法迁移效应产生的机制,着重考查了组块信息迁移理论对人工语法迁移效应机制解释的适宜性。结果发现：当学习和测验序列的表层结构不同时,被试能够学习和迁移非重复成分间的序列依存性(实验一);当被试将非重复成分间的序列依存性迁移到表层结构不同的测验序列中时,需要在学习和测验序列的分布特征上形成一种匹配(实验二)。     

任务框架及利他人格对社会折扣的影响

与自我存在一定社会距离的他人获得收益或遭受损失都会给自我带来一定的效用,这种效用随着与他人间社会距离的增加而减少,该现象被称为社会折扣。本研究采用情境式选择滴定程序,探索并比较了“为他人得益而放弃自我得益”(NG-G)、“为他人不失而放弃自我得益”(NG-NL)、“为他人得益而承担自我损失”(L-G)以及“为他人不失而承担自我损失”(L-NL)4种任务框架下的社会折扣程度。结果发现：(1)4种框架下,指数模型均比双曲模型更好地描绘了被试的社会折扣规律;(2)任务框架影响社会折扣程度,“为他人不失”框架下(含NG-NL、L-NL)的折扣程度比“为他人得益”框架下(含NG-G、L-G)低;(3)任务框架与社会距离的交互作用影响社会折扣程度。随着社会距离增加, NG-G与NG-NL框架下折扣程度的差异逐渐变小, L-G与L-NL框架下折扣程度的差异也逐渐变小;(4)社会距离与利他人格的交互作用显著,高低利他人格者的社会折扣程度只在社会距离较远时存在显著差异。上述结果表明,个体不仅存在自我损失规避倾向,也存在不同程度的他人损失规避倾向。