Dissociation of reward and effort sensitivity in methcathinone‐induced Parkinsonism |
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| Authors: | Trevor T.‐J. Chong Valerie Bonnelle Kai‐Riin Veromann Julius Juurmaa Pille Taba Olivia Plant Masud Husain |
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| Affiliation: | 1. Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, Victoria, Australia;2. Department of Experimental Psychology, University of Oxford, UK;3. Nuffield Department of Clinical Neurosciences, University of Oxford, UK;4. Department of Neurology and Neurosurgery, University of Tartu, Estonia |
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| Abstract: | Methcathinone‐induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost‐benefit decision‐making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained. |
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| Keywords: | Parkinsonism methcathinone motivation effort reward |
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