| 精神分裂症肠道微生物与脑影像和临床表征的关系 |
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| 引用本文： | 周振友,孔丽,陈楚侨. 精神分裂症肠道微生物与脑影像和临床表征的关系[J]. 心理科学进展, 2022, 30(8): 1856-1869. DOI: 10.3724/SP.J.1042.2022.01856 |
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| 作者姓名： | 周振友 孔丽 陈楚侨 |
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| 作者单位： | 1.上海师范大学心理系, 上海 200234;2.华东师范大学城市化生态过程与生态恢复重点实验室, 上海 200241;3.中国科学院心理研究所心理健康重点实验室, 神经心理学与认知神经科学研究室, 北京 100101 |
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| 基金项目： | 国家自然科学项目(82071501);国家自然科学项目(81601170);上海市城市化生态过程与生态恢复重点实验室开放课题(SHUES2020A04) |
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| 摘 要： | 微生物-肠-脑轴假设在精神分裂症发病机制中的研究受到越来越多的关注。以往研究初步考察了肠道微生物的构成与精神分裂症患者脑影像和临床表征之间的联系,但具体的作用路径尚不明确。当前研究通过总结最新研究进展,并在此基础上提出肠道微生物影响精神分裂症患者大脑结构和功能的机制假设。相关内容对于进一步阐明精神分裂症的病理机制,为将肠道微生物纳入精神分裂症的评估与干预提供理论基础。
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| 关 键 词： | 精神分裂症 肠道微生物 微生物-肠-脑轴 脑影像 临床表征 |
| 收稿时间： | 2021-10-09 |
The relationship between gut microbiota and brain imaging and clinical manifestation in schizophrenia |
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| ZHOU Zhenyou,KONG Li,CHAN Raymond. The relationship between gut microbiota and brain imaging and clinical manifestation in schizophrenia[J]. Advances In Psychological Science, 2022, 30(8): 1856-1869. DOI: 10.3724/SP.J.1042.2022.01856 |
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| Authors: | ZHOU Zhenyou KONG Li CHAN Raymond |
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| Affiliation: | 1.Department of Psychology, Shanghai Normal University, Shanghai 200234, China;2.Shanghai Key Lab for Urban Ecological Processes and Eco-restoration, East China Normal University, Shanghai 200241, China;3.Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | The microbiota-gut-brain axis hypothesis has attracted more and more attention in the research of the pathogenesis of schizophrenia. This hypothesis stated that gut microbiota can cause inflammation in the brain of patients with schizophrenia and cause abnormalities of brain function through the intestinal immune system, and that early colonization of gut microbiota will affect the development of the central nervous system in patients with schizophrenia and thus cause abnormalities of brain structure. Previous research has preliminarily investigated the relationship between the composition of gut microbiota and the brain imaging and clinical manifestation of patients with schizophrenia, but the specific action path is still unclear. |
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| Keywords: | schizophrenia gut microbiota microbiota-gut-brain axis brain imaging clinical manifestation |
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