Cognitive-Behavior Therapy (CBT) for Panic Disorder: Relationship of Anxiety and Depression Comorbidity with Treatment Outcome |
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Authors: | Laura B Allen Kamila S White David H Barlow M Katherine Shear Jack M Gorman Scott W Woods |
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Institution: | (1) Department of Pediatrics, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 22-464 MDCC, Los Angeles, CA 90095, USA;(2) Department of Psychology, University of Missouri—St. Louis, St. Louis, MO, USA;(3) Department of Psychology, Boston University, Boston, MA, USA;(4) Department of Psychiatry, Columbia University School of Social Work, New York, NY, USA;(5) Comprehensive NeuroScience, Inc., White Plains, NY, USA;(6) Department of Psychiatry, Yale University, New Haven, CT, USA |
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Abstract: | Research evaluating the relationship of comorbidity to treatment outcome for panic disorder has produced mixed results. The
current study examined the relationship of comorbid depression and anxiety to treatment outcome in a large-scale, multi-site
clinical trial for cognitive-behavior therapy (CBT) for panic disorder. Comorbidity was associated with more severe panic
disorder symptoms, although comorbid diagnoses were not associated with treatment response. Comorbid generalized anxiety disorder
(GAD) and major depressive disorder (MDD) were not associated with differential improvement on a measure of panic disorder
severity, although only rates of comorbid GAD were significantly lower at posttreatment. Treatment responders showed greater
reductions on measures of anxiety and depressive symptoms. These data suggest that comorbid anxiety and depression are not
an impediment to treatment response, and successful treatment of panic disorder is associated with reductions of comorbid
anxiety and depressive symptoms. Implications for treatment specificity and conceptual understandings of comorbidity are discussed. |
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