| 热休克蛋白7O在动脉粥样硬化发病中的双重作用 |
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| 引用本文： | 黄锋,周胜华,贺达仁.热休克蛋白7O在动脉粥样硬化发病中的双重作用[J].医学与哲学,2010(6):42-43,48. |
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| 作者姓名： | 黄锋 周胜华 贺达仁 |
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| 作者单位： | [1]中南大学湘雅二医院心内科,湖南长沙41001l [2]中南大学公共管理学院,湖南长沙410078 |
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| 摘 要： | 大多研究表明，热休克蛋白70通过抗凋亡、抗氧化及抗炎症反应而在动脉粥样硬化发病中起保护作用。但亦有研究表明，热休克蛋白70通过促凋亡、促进炎症反应而在动脉粥样硬化的发生发展中起促进作用。说明热休克蛋白70在动脉粥样硬化发病中有双重作用，进行基础研究和临床干预时应考虑到其双面性。
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| 关 键 词： | 热休克蛋白70 动脉粥样硬化 双重作用 |
Dual Role of Heat Shock Protein--70 in the Pathogenesis of Atherosclerosis |
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| HUANG Feng,ZHOU Sheng-hua,HEDa-ren.Dual Role of Heat Shock Protein--70 in the Pathogenesis of Atherosclerosis[J].Medicine & Philosophy:Humanistic & Social Medicine Edition,2010(6):42-43,48. |
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| Authors: | HUANG Feng ZHOU Sheng-hua HEDa-ren |
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| Institution: | .( Department of Cardiology ,the Second Xiangya Hospital, Central South University, Changsha 410011, China) |
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| Abstract: | Most studies have shown that Heat Shock Protein--70 plays a protective role in the pathogenesis of atherosclero- sis by anti--apoptotic, antioxidant and anti--inflammatory response. However, some studies have shown that Heat Shock Protein--70 plays a contrast role in the occurrence and development of atherosclerosis by inducing apoptosis and inflamma- tion. It showed that Heat Shock Protein--70 has a dual role in the pathogenesis of atherosclerosis. We should pay atten- tion to its double--sided nature while conducting basic research and clinical intervention. |
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| Keywords: | Heat Shock Protein- 70 atherosclerosis dual role |
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