| 激素替代治疗对绝经妇女心脏保护效应的重新认识 |
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| 引用本文： | 黄志军,沈守荣,袁洪. 激素替代治疗对绝经妇女心脏保护效应的重新认识[J]. 医学与哲学(人文社会医学版), 2008, 29(8): 50-51 |
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| 作者姓名： | 黄志军 沈守荣 袁洪 |
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| 作者单位： | 中南大学湘雅三医院,湖南长沙410013 |
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| 基金项目： | 致谢：感谢中南大学湘雅医学院社会科学部贺达仁教授对本文的悉心指导 |
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| 摘 要： | 激素替代疗法（HRT）已有数十年历史，但是否具有心脏保护效应一直存在争议。早期研究提示HRT可维持血管正常功能，但大样本随机对照研究却发现服用雌激素和孕激素妇女的心血管疾病较安慰剂组增加22％，这导致了HRT应用的急剧减少。而2007年妇女健康启动计划——冠状动脉钙化研究（WHI—CACS）却证实HRT能显著降低冠状动脉钙化，再次提起了人们对HRT心脏保护效应的关注。
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| 关 键 词： | 激素替代治疗 雌激素 心脏 冠心病 |
Reconsider on the Protective Effect on Heart of Hormone Replacement Therapy in Postmenopausal Women |
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| HUANG Zhi- jun,SHEN Shou- rong,YUAN Hong. Reconsider on the Protective Effect on Heart of Hormone Replacement Therapy in Postmenopausal Women[J]. Medicine & Philosophy:Humanistic & Social Medicine Edition, 2008, 29(8): 50-51 |
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| Authors: | HUANG Zhi- jun SHEN Shou- rong YUAN Hong |
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| Affiliation: | .( The Third Xiangya Hospital, Centre South University, Changsha 410013, China) |
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| Abstract: | Hormone replacement therapy （ HRT） has been used for a long time, but whether it has heart protective effect is still in dispute. Earlier researches suggested that HRT could maintain the normal function of vessels. However, a large sample randomized controlled trial discovered that with HRT therapy the total cardiovascular disease in estrogen plus progesterone group increased by 22% , compared to the placebo group. This result directly caused the rapid reduction of the HRT application. In 2007, however, the WHI--CACS actually confirmed that HRT could significantly reduce the coronary artery calcification. This study resulted in the heart protective effect of HRT be paid more attention to once again. |
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| Keywords: | hormone replacement therapy estrogen heart coronary heart disease |
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