尼莫地平对高钙和东莨菪碱所致记忆障碍的改善作用

利用氯化钙和东莨菪碱（海马内注射）分别造成小鼠学习、记忆障碍模型，观察了尼莫地平（腹腔注射）对学习记忆障碍的影响，并以3H—Leu为标记物进行同位素示踪，观察了三种药物对小鼠海马突触体摄取3H—Leu的影响。结果表明，尼莫地平能改善氯化钙和东莨菪碱所致的学习记忆障碍，但不能逆转这两种药物导致的3H—Leu掺入量的减少。提示钙拮抗剂尼莫地平改善化学性记忆障碍的作用不通过促进突触蛋白合成的途径。

THE AMELIORATION OF NIMODIPINE ON CHEMICAL LEARNING AND MEMORY DYSFUNCTION RESULTS FROM INTRAHIPPOCAMPAL INJECTION OF CaCl2 AND SCOPOLAMINE

The influence of nimodipine(ip) on chemical learning and memory dysfunction from intrahippocampal injection of CaCI 2 and scopolamine were investigated,and the effects of three agents(CaCI 2 , scopolamine and nimodipine )on the incorporation of 3 H-Leu into hippocampal symaptosomes were observed.The results showed that intrahippocampal injection of CaCI 2 and scopolamine could cause chemical learning and memory dysfunction significantly (p<0.01 and p<0.05), nimodipine could ameliorate chemical learning and memory dysfunction obviously (p<0.05 and p<0.01), CaCI 2 and scopolamine could reduce incorporation of 3 H-Leu into hippocampal symaptosomes apparently (p<0.01and p<0.001), but,in vitro,it couldn't antagonize the reduction of incorporation of 3 H-Leu into hippocampal symaptosomes resulted from these two agents .These results suggested that there might exist other mechanism of Ca 2 channel antagonist nimodipine on ameliorating memory impairment instead of improving synaptosomal protein syntheses.