血管性认知功能障碍与胰岛素抵抗关系的临床研究

探讨在血管性认知功能障碍（vascular cognitive impairment，VCI）的发病机制中胰岛素抵抗（insulin resistance，IR）的作用及二者之问的关系。比较41例VCI患者与80例健康对照组中空腹血糖（FPG）等13个因素之间是否存在差异，及VCI的发生与上述各因素之间的关系。VCI组FPG、FINS、HOMA-IR、ISI、FIB、TC、TG、LDL明显高于对照组（P〈0．01或P〈0．05）；其中FINS、HOMA-IR、LDL为VCI发生的危险因素；MMSE评分与ISI呈显著正相关（rs=0．56，P〈O．01）。VCI中存在IR，IR是VCI发生的危险因素之一，VCI的严重程度与IR呈正相关。

Relationship between Vascular Cognitive Impairment and Insulin Resistance

Evaluate the effects of insulin resistance （IR） in vascular cognitive impairment（ VCI） and the relationship between them. Discuss the differences of FPG,FINS etc. 13 factors between 41 patients diagnosed with VCI and 80 patients of control group,and the relationships with VCI. There were significant differences in FPG, FINS, HOMA-IR, ISI, FIB, TC, TG, LDL[P〈0. 01 or P〈0.05）between VCI and control group. FINS, HOMA-IR and LDL are the risk factors of VCI. MMSE was positively correlated with ISI （rs=0.56,P〈0.01）. IR exists in VCI,which is one of the risk factors of it. The severity of VCI is positively correlated with IR.