Management of extended-wear contact lenses in infant rhesus monkeys

Infant rhesus monkeys were fitted with extended-wear contact lenses (EWCLs) to correct surgically induced aphakia. The protocol that produced the most favorable experimental outcome, including good lens-wear compliance, involved: (1) custom-made EWCLs with parameters adjusted for each animal, (2) selection for study of neonates who seemed to tolerate EWCLs most naturally, (3) individual housing of monkeys, (4) lens check at 2-h intervals around the clock by trained personnel, (5) a large inventory of EWCLs for each animal, (6) periodic ophthalmologic examinations, and (7) darkroom housing of monkeys during treatment of lens-wear-related incidents. The EWCL is a new tool for studies of the visual system and is a useful complement to existing experimental techniques.