| 晚发性抑郁的生物学机制 |
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| 引用本文： | 张炳蔚 许晶. 晚发性抑郁的生物学机制[J]. 医学与哲学(人文社会医学版), 2006, 27(9): 53-57 |
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| 作者姓名： | 张炳蔚 许晶 |
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| 作者单位： | 大连医科大学第一临床学院神经内科 辽宁大连116011 |
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| 基金项目： | 国家自然科学基金资助,项目编号：30570477 |
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| 摘 要： | 晚发性抑郁是指发病年龄大于60岁的一组抑郁综合征,发病机制至今尚不明确。研究表明,晚发性抑郁的遗传因素不明显,而血管损害则与之密切相关;多数患者伴有明显的执行功能损害,痴呆的发病风险增高。围绕晚发性抑郁的两个基本特征:血管损害与认知障碍做一回顾,初步探讨了晚发性抑郁生物学机制对临床决策的影响,并由此展望了未来的研究方向。
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| 关 键 词： | 抑郁 老年 血管损害 执行功能 认知神经科学 |
| 文章编号： | 1002-0772（2006）09-0053-05 |
| 收稿时间： | 2006-07-28 |
| 修稿时间： | 2006-07-28 |
Biological Mechanism of Late-onset Depression and Clinical Strategy |
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| ZHANG Bing-wei, XU ring.. Biological Mechanism of Late-onset Depression and Clinical Strategy[J]. Medicine & Philosophy:Humanistic & Social Medicine Edition, 2006, 27(9): 53-57 |
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| Authors: | ZHANG Bing-wei XU ring. |
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| Affiliation: | Department of Neurology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China. |
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| Abstract: | Late-onset depression(LOD) is known as a depressive syndrome that occurs more than sixty years old. Genetic factors are generally thought to be of less significance in late-onset depressed patients, and subjects with LOD show a stronger relationship with vascular disease. Executive dysfunction is common in LOD with a increasing risk of dementia. Vascular impairment and cognitive dysfunction, two pivotal factors involved in LOD, are reviewed in this article. Furthermore, we discussed how the biological mechanisms affect clinical decision-making of LOD, and made a prospective view of research direction. |
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| Keywords: | depression aged vascular impairment executive function cognitive neuroscience |
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