慢性乙型肝炎的联合抗病毒治疗

抗病毒治疗是控制乙型肝炎病原进而防止肝硬化、肝癌等并发症的重要手段。就目前的抗病毒药物而言，单一药物的疗效不能令人满意，越来越多的研究数据表明联合抗病毒治疗，包括干扰素α和核苷（酸）类似物联合治疗以及两种核苷（酸）类似物联合治疗可以减少耐药发生，提高抗病毒疗效。联合抗病毒治疗可能是控制乙肝的有效策略，值得进一步研究。

Combination Therapy for Chronic Hepatitis B

Antiviral therapy play a very important role in controlling HBV infection and preventing the development of complications such as cirrhosis,hepatic carcinoma. But so far available antiviral medicines are con-cerned,monotherapy is not so satisfactory. There are increasing evidences show that combination therapy sucn as interferon alpha （pegylated interferon alpha） plus nucleoside/nucleotide analogue or combined two kinds of nucleoside/nucleotide analogues could decrease risk of drug resistance and improve antiviral effect. Combination therapy might be a good choice for chronic hepatitis B and deserve further study.