| 癌蛋白促凋亡现象引发的思考 |
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| 引用本文： | 贾勇圣,郑建全,魏晓莉,李昕,牟男.癌蛋白促凋亡现象引发的思考[J].医学与哲学,2007,28(7):39-41. |
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| 作者姓名： | 贾勇圣 郑建全 魏晓莉 李昕 牟男 |
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| 作者单位： | 军事医学科学院毒物药物研究所 北京100850 |
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| 摘 要： | 肿瘤生物学中一个矛盾现象是:曾经被认为促进肿瘤生长增殖的癌蛋白,现在发现它可以引起肿瘤细胞自杀。自杀行为由癌蛋白促凋亡介导完成,MYC是其中的典型代表,癌蛋白的这种行为可能对肿瘤的发生发展具有重大意义,目前通过诱导肿瘤细胞凋亡治疗癌症是否完全合理,有待临床实践的进一步验证,今后的抗癌治疗应该辩证合理地看待肿瘤细胞凋亡。
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| 关 键 词： | 癌蛋白 凋亡 MYC |
| 文章编号： | 1002-0772（2007）07-0039-03 |
| 修稿时间： | 2007-04-252007-06-01 |
The Thinking of the Oncoprotein Induced Apoptosis |
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| JIA Yong-sheng , ZHENG Jian -quan, WEI Xiao - li ,et al..The Thinking of the Oncoprotein Induced Apoptosis[J].Medicine & Philosophy:Humanistic & Social Medicine Edition,2007,28(7):39-41. |
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| Authors: | JIA Yong-sheng ZHENG Jian -quan WEI Xiao - li |
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| Institution: | Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China |
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| Abstract: | A paradox for the cancer biology field has been the revelation that oncoprotein, once thought to simply provide advantages to a cancer cell, actually put it at dire risk of cell suicide. The suicidal behavior is carried out by the oncoprotein-induced apoptosis, Myc is the quintessential oncoprotein in this respect. This kind of apoptosis may play an important role in tumorigenesis and tumor progression. The rationality of the therapeutic strategy by promoting tumor cells apoptosis should be reconsidered.In the future,tumor apoptosis should be applied dialectically in anti-tummor therapy. |
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| Keywords: | oncoprotein apoptosis MYC |
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