Imaging intelligence with proton magnetic resonance spectroscopy |
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| Authors: | Rex E. Jung Charles Gasparovic Robert S. Chavez Arvind Caprihan Ranee Barrow Ronald A. Yeo |
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| Affiliation: | 1. Institute of Imaging Science, Vanderbilt University, 1161 21st Ave. South, MCN AA-1105, Nashville, TN 37232-2310, USA;2. Department of Radiology and Radiological Sciences, Vanderbilt University, 116 21st Ave. South, MCN CCC-1106, Nashville, TN 37232-2675, USA;1. Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;2. Department of Radiology, Stanford University, Stanford, CA, USA;3. Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA |
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| Abstract: | Proton magnetic resonance spectroscopy (1H-MRS) is a technique for the assay of brain neurochemistry in vivo. N-acetylaspartate (NAA), the most prominent metabolite visible within the 1H-MRS spectrum, is found primarily within neurons. The current study was designed to further elucidate NAA–cognition relationships, particularly whether such relationships are moderated by sex, or tissue type (gray or white matter). We administered standard measures of intelligence to 63 young, healthy subjects and obtained spectroscopic imaging data within a slab of tissue superior to the lateral ventricles. We found that lower NAA within right anterior gray matter predicted better performance VIQ (F = 6.83, p = .011, r2 = .10), while higher NAA within the right posterior gray matter region predicted better PIQ (F = 8.175, p = .006, r2 = .12). These findings add to the small but growing body of literature linking brain biochemistry to intelligence in normal healthy subjects using 1H-MRSI. |
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