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Childhood anxiety associated with low BMI in women with Anorexia Nervosa |
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| Authors: | Jocilyn E. Dellava Robert M. Hamer Michael Strober Kelly L. Klump Steve Crawford Katherine A. Halmi Craig Johnson Maria LaVia Alessandro Rotondo D. Blake Woodside Walter H. Kaye |
| Affiliation: | a Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB #7160, Chapel Hill, NC 27599-7160, USA b Department of Biostatistics, University of North Carolina at Chapel Hill, 336 Medical School Wing B, The University of North Carolina Chapel Hill 27599, USA c Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA d Department of Psychiatry, University of Pittsburgh, WWPH 3112 Pittsburgh, Pittsburgh, PA 15260, USA e Department of Psychology, Michigan State University, 107B Psychology Building, East Lansing, MI 48824-1116, USA f Department of Psychiatry, University of Maryland School of Medicine, 6501 North Charles Street, Towson, MD 21285, USA g Roseneck Hospital for Behavioral Medicine, Am Roseneck 6, D-83209 Prien, Germany h Department of Psychiatry, University of Munich (LMU), Nussbaumstrasse 7, D-80336, Munich, Germany i New York Presbyterian Hospital-Westchester Division, Weill Medical College of Cornell University, 21 Bloomingdale Rd., White Plains, NY, USA j Department of Psychological Medicine, University of Birmingham, B15 2QZ, Birmingham, UK k Laureate Psychiatric Clinic and Hospital, 6655 S. Yale Avenue, Tulsa, OK 74136, USA l Department of Psychiatry, The Toronto Hospital, College Wing 1-311, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada m Neuropsychiatric Research Institute, 120 8th St. S., Fargo, ND 58102, USA n Department of Psychiatry, Pharmacology and Biotechnologies, University of Pisa, Via Bonanno, 6, Pisa, PI 56126, Italy o Department of Psychiatry, Institute of Psychiatry, Kings College, De Crespigny Park, SE5 8AF, London, United Kingdom p Department of Psychiatry, University of Pennsylvania, School of Medicine, Room 2206, 125 S. 31st Street Philadelphia, PA 19104, USA q Department of Psychiatry, University of California, 9500 Gilman Drive #0985, La Jolla, CA 92093-0985, USA r Department of Nutrition, University of North Carolina at Chapel Hill, CB #7160, Chapel Hill, NC 27599-7160, USA |
| Abstract: | ObjectiveExtremely low body mass index (BMI) values are associated with increased risk for death and poor long-term prognosis in individuals with anorexia nervosa (AN). The present study explores childhood personality characteristics that could be associated with the ability to attain an extremely low BMI.MethodsParticipants were 326 women from the Genetics of Anorexia Nervosa (GAN) Study who completed the Structured Interview for Anorexia Nervosa and Bulimic Syndromes and whose mother completed the Child Behavioral Checklist and/or Revised Dimensions of Temperament Survey.ResultsChildren who were described as having greater fear or anxiety by their mothers attained lower BMIs during AN (p < 0.02). Path analysis in the GAN and a validation sample, Price Foundation Anorexia Nervosa Trios Study, confirmed the relation between early childhood anxiety, caloric restriction, qualitative food item restriction, excessive exercise, and low BMI. Path analysis also confirmed a relation between childhood anxiety and caloric restriction, which mediated the relation between childhood anxiety and low BMI in the GAN sample only.ConclusionFearful or anxious behavior as a child was associated with the attainment of low BMI in AN and childhood anxiety was associated with caloric restriction. Measures of anxiety and factors associated with anxiety-proneness in childhood may index children at risk for restrictive behaviors and extremely low BMIs in AN. |
| Keywords: | Anorexia Nervosa Anxiety Body mass index |
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