Using empirical data to inform the ethical evaluation of placebo controlled trials |
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Authors: | Email author" target="_blank">Jeremy?SugarmanEmail author |
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Institution: | (1) Phoebe R. Berman Bioethics Institute, Johns Hopkins University, Hampton House 351, 624 North Broadway, 21205 Baltimore, MD, USA |
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Abstract: | There has been considerable debate about the ethical acceptability of using placebo-controls in clinical research. Although
this debate has been rich in rhetoric, considering that much of this research is predicated upon the assumption that data
from this research is vital to clinical decision-making, it is ironic that researchers have introduced little data into these
discussions. Using some published research concerning the use of placebo-controls in clinical research in hypertension and
psychiatric drug trials, I suggest some ways that such data might be incorporated into the ethical analysis concerning placebo
use in clinical trials. This approach promises to be important for enhancing conceptual and scientific understanding as well
as public policy decision-making.
An earlier version of this paper was presented at an international conference, “Placebo: Its Action and Place in Health Research
Today,” held in Warsaw, Poland on 12–13 April, 2003. |
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Keywords: | placebos ethics research ethics clinical trials |
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