Risk Reduction Behaviors and Provider Communication Following Genetic Counseling and BRCA1 Mutation Testing in an African American Kindred |
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| Authors: | Anita Yeomans Kinney Sara Ellis Simonsen Bonnie Jeanne Baty Diptasri Mandal Susan L. Neuhausen Kate Seggar Richard Holubkov Lindsey Bloor Ken Smith |
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| Affiliation: | (1) Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA;(2) Division of Clinical Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA;(3) Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah, USA;(4) Department of Genetics, Louisiana State University Health Sciences Center, Louisiana State University, New Orleans, Louisiana, USA;(5) Epidemiology Division, School of Medicine, University of California, Irvine, California, USA;(6) Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah, USA;(7) Department of Family and Consumer Studies, University of Utah, Salt Lake City, Utah, USA;(8) Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA |
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| Abstract: | Little is known about the impact of cancer genetic counseling and testing on health behaviors in racial and ethnic subgroups. This prospective observational study examined use of risk reduction strategies following BRCA1 counseling and testing. Participants were female members of an African American kindred who received genetic education, counseling and testing (n = 40) and completed a 1-year follow-up interview. Mutation carriers were more likely to opt for breast (100%, 7/7) and ovarian (25%; 1 of 4) cancer surveillance than prophylactic surgery. Following genetic counseling, 71% (5/7) of the BRCA1 carriers who opted for surveillance reported having a mammogram within the year following receipt of their genetic test results. Ovarian cancer screening among mutation carriers increased from 0% at baseline to 25% (one of four) at 1 year. Compared to noncarriers (23%, 7/30), carriers (70%, 7/10) were more likely to discuss their BRCA1 test results with their primary health care providers. Surveillance for breast cancer was preferred to prophylactic surgery and chemoprevention as a way to reduce risk for these cancers. Our data indicate that patient-provider communication about BRCA1 test results is suboptimal. |
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| Keywords: | breast/ovarian cancer screening BRCA1 gene mutation genetic testing African Americans |
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