d-Serine facilitates the effects of extinction to reduce cocaine-primed reinstatement of drug-seeking behavior |
| |
| Authors: | Lakshmi Kelamangalath Claire M. Seymour John J. Wagner |
| |
| Affiliation: | aDepartment of Physiology and Pharmacology, University of Georgia, Athens, USA;bInterdisciplinary Toxicology Program, University of Georgia, Athens, USA;cNeuroscience Program, University of Georgia, Athens, USA |
| |
| Abstract: | Male Sprague Dawley rats were allowed to self-administer cocaine (0.5 mg/kg) during 90 min sessions for a period of 15 days. On day 16, rats were either held abstinent in their home cage environment or experienced an extinction session in which the active lever had no programmed consequences. Facilitating N-methyl-d-aspartate (NMDA) receptor activity with the coagonist d-serine (100 mg/kg i.p.) before or following the extinction session significantly reduced the subsequent cocaine-primed reinstatement of drug-seeking behavior tested on day 17. d-Serine significantly reduced drug-primed reinstatement only when combined with extinction, and its effectiveness when administered following the training session suggested that an enhancement of consolidation of extinction learning had occurred. In contrast, d-serine treatment did not reduce sucrose-primed reinstatement, indicating that the beneficial effects of this adjunct pharmacotherapy with extinction training were specific to an addictive substance (cocaine) and did not generalize to a natural reward (sucrose). |
| |
| Keywords: | Self-administration Cocaine NMDA receptor Glycine coagonist Addiction Extinction |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
