Cognitive function after open-heart surgery: Are postoperative neuropsychological deficits caused by cardiopulmonary bypass?

Despite the many technological developments in arterial perfusion and cardiac surgical procedures, open-heart surgery is still believed to pose a significant risk for cerebral injury. There are several potential causes of brain damage during open-heart surgery, including prolonged or severe arterial hypotension, as well as emboli emanating from the cardiopulmonary bypass circuit or the operative field. This article reviews the available neuropsychological studies of outcome following cardiac valve replacement and coronary artery bypass grafting. Because both procedures are life-saving operations, the research in this area has been quasi-experimental and fraught with methodological problems. Nonetheless, the findings converge to suggest that cognitive dysfunction occurs after open-heart surgery, and that the deficits are attributable, at least in part, to factors specific to the operation or to the patient being maintained on cardiopulmonary bypass. Preliminary findings suggest that embolization is the primary cause of perioperative deficits in uncomplicated operations. Studies have also consistently found preoperative deficits in this population, suggesting that neuropsychological dysfunction is caused by severe chronic cardiac disease as well as open-heart surgery.     

Is Speech Arrest during Wada Testing a Valid Method for Determining Hemispheric Representation of Language?

Background and objective: The intracarotid amobarbital procedure, or Wada test, is the method of choice to determine hemispheric representation of language, and is routinely used in the presurgical evaluation for intractable epilepsy. Some investigators perform comprehensive language assessments, but others base language lateralization solely on speech arrest. This study sought to determine whether speech arrest alone during Wada testing provides valid data regarding language lateralization. Methods: The subjects (previously reported) were 21 patients evaluated for intractable epilepsy, who underwent language lateralization by Wada testing and functional MRI (FMRI). For each patient, language representation was determined by calculating: (1) a Wada laterality index based exclusively on speech arrest; (2) a Wada laterality index based on comprehensive language assessment; and (3) an FMRI laterality quotient. Correlation coefficients and categorical classifications were analyzed. Results: There was no significant correlation between the Wada laterality quotient derived from duration of speech arrest and either the comprehensive Wada language laterality score (r= .35,p= .12) or FMRI language laterality score (r= .32,p= .16). Categorical classification as left, right or bilateral language also showed marked discordance between speech arrest and the other two methods. Conclusion: Duration of speech arrest during Wada testing is not a valid measure of language dominance.     

Sculpting the Body Beautiful: Attachment Style,Neuroticism, and Use of Cosmetic Surgeries

Use of cosmetic surgeries has increased steadily over the last decade, and continues to rise in young and old alike. The purpose of present research was to investigate the relationship of personality to use of cosmetic procedures of various kinds. It was expected that adult attachment style, in particular attachment anxiety, would be positively related to use of cosmetic procedures. Attachment anxiety involves excessive approval seeking and concern over achieving and maintaining the love of significant others (such as romantic relationship partners). Such concerns could, in turn, lead to use of a variety of strategies for maintaining positive regard, including cosmetic surgeries to enhance physical appearance. Results supported this hypothesis, particularly among women. Neuroticism was also related to some procedures, though the relationships were generally weaker than those for attachment anxiety, and largely disappeared in regression analyses that controlled for the separate influence of the two variables.     

Menarche,Menstruation, and Gender Identity: Retrospective Accounts from Women Who Have Undergone Premenopausal Hysterectomy

Hysterectomy (the surgical removal of the uterus) precipitates the end of menstrual cycles in premenopausal women. In this article I explore whether that premature termination of menstrual function negatively affects women's subjective gender identities. Using the grounded theory research approach, I conducted in-depth interviews with 40 diverse respondents who had undergone premenopausal hysterectomy. These women generally acknowledged that, since the time of menarche, they had closely associated menstruation with their gender identities. However, despite some regrets, respondents' primary reaction was almost unanimous relief that they had ceased menstruating. This finding must be viewed in the context of overwhelming and uncontrollable menstrual pain and bleeding that many respondents had previously experienced. Contrary to expressing remorse that they no longer identified with normal women, who menstruate, most respondents sought to disassociate themselves from the normalized suffering that they perceived is endured by all menstruating women.     

Acceptance of cosmetic surgery: scale development and validation

We conducted a set of four studies with a total of 1288 adult and undergraduate women and men to develop the Acceptance of Cosmetic Surgery Scale. These studies provide evidence of this scale's reliability, as well as convergent and discriminant validity. Initial explorations using this 15-item scale indicate that acceptance of cosmetic surgery is negatively related to satisfaction with physical appearance and positively related to attitudes about make-up use. The acceptance of cosmetic surgery may be more related to fears about becoming unattractive than to hopes of becoming more attractive. Cosmetic surgery attitudes were positively related to age for women but not for men. The study's limitations and implications are discussed.     

Narcotrend监测下右美托咪定对冠心病患者麻醉诱导期血流动力学的影响

观察Narcotrend监测下右美托咪定联合丙泊酚靶控输注用于冠心病患者非心脏手术麻醉诱导时对血流动力学的影响.合并冠心痛行非心脏手术患者40例,随机分为两组：Dex组（n=20,患者在诱导前静脉泵注右美托咪定0.5μg/kg,15min内输注完毕）,对照组（n=20,等量生理盐水,方法同Dex组）.记录给药前后及诱导期间患者的血流动力学变化.对照组在气管插管即刻以及气管插管3min后血流动力学指标值均高于插管前,气管插管5min后平均动脉压（MAP）低于插管前（P＜0.05）,Dex组无明显差异.麻醉诱导前15min静脉注射0.5μg/kg右美托咪定可以使冠心病患者丙泊酚靶控输注诱导期间血流动力学更加平稳.     

原发灶切除在转移性乳腺癌治疗中的地位

无论是国内还是世界其他国家,乳腺癌近年来已成为女性常患恶性肿瘤之首。早期乳腺癌通过手术、化疗、放疗及内分泌治疗等综合治疗后可以达到长期生存。然而对于晚期乳腺癌,特别是伴有远处转移的乳腺癌,疗效却不尽如人意。对于转移性乳腺癌,目前治疗优先选择毒性尽可能小的全身系统性治疗方案;而对于需要缓解症状或避免即将发生并发症（如皮肤溃疡、出血、真菌感染以及疼痛等）的情况可于全身治疗后行相应手术。然而对于转移性乳腺癌是否手术切除原发灶以及是否可从手术中获益,仍然充满争议。     

处理好心血管手术中体外循环的几个关系

随着医学技术的进步,近年来通过手术来解除患者心血管方面的疾患已成为一种有效的方法。开展心血管手术离不开体外循环,然而,体外循环是一门交叉学科,它涉及医学和非医学等多方面的知识,实施过程中还会对患者机体产生不同程度的影响。从非医学方面的哲学角度来看,体外循环的整个过程中都包含有丰富的唯物辩证法观点,用联系的、矛盾的、辩证的哲学思维去看待体外循环中的相关问题,有助于提高体外循环灌注技术的质量,减少对患者机体的损伤。     

多媒体技术在医患沟通中的临床应用实践——以胸外科患者为例

伴随着网络信息技术的飞速发展,医学卫生行业正在跨入信息化时代,本课题采用多媒体技术的多样性、集成性、交互性和实时性的特点,使用自制多媒体术前谈话课件进行医患沟通.通过将胸外科拟手术患者随机分为试验组及对照组,试验组采用多媒体课件进行医患沟通,对照组采用传统方式沟通,分别统计分析两组患者沟通质量满意度,来探讨多媒体技术在胸外科医患沟通中的临床应用.采用多媒体技术进行医患沟通可以显著提高患者满意度,值得在临床工作中进一步推广.     

构建高质量的外科医学教育体系

医学教育是贯穿医疗职业生涯全过程的行为,是伴随医学进步和发展的重要工程.医学教育的质量直接影响医疗的质量和医学人才的素质,尤其是外科学领域,是以有创性的手段、方法治疗疾病.医生的职业素养、医疗水平均取决于医学教育的结果.医疗质量不能简单地用医生的学历衡量,学历教育是载体,其中应充实培养能力的教育项目、内容,以适应未来就职、就业的社会需求.医疗质量、医疗水平对医院而言是生命线,是生产力.同时,医生的教育及教育的质量是医疗质量的基础与保障.随着医学的飞速发展,医疗技术的日新月异,医学模式的改变,构建新的医疗环境下的医学教育体系,显得更为重要.