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《Médecine & Droit》2021,2021(169):74-80
As the first vaccines against COVID-19 arrive on the market, the question of the safety of these products arises in the public debate. The major concern is about the possible occurrence of adverse effects, particularly in the context of the use of novel pharmaceutical technologies such as mRNA. It is important to remind both patients and professionals that a vaccine is not only a medicinal product in its own right, but also a special medicinal product: biological and immunological. As a result, its supervision is draconian, and despite the urgency, no requirements have been lowered. The speed of marketing is the result both of adapted clinical trials and optimized evaluation procedures. 相似文献
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幽门螺杆菌感染与慢性胃炎、消化性溃疡、胃癌及胃黏膜相关性淋巴瘤有关。疫苗是防治幽门螺杆菌感染切实可行的方法。近年来新的防治和根除幽门螺杆菌感染的疫苗正在开发并取得了很大的进展。本综述结合本室研制Hp疫苗的研究基础,简要概述疫苗保护性抗原的筛选、黏膜免疫佐剂及接种途径、Hp疫苗的保护性免疫机制、Hp感染动物模型的建立及Hp疫苗人体临床试验等方面的研究进展。 相似文献
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《Trends in cognitive sciences》2015,19(11):633-636
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Lynn Waterhouse 《Neuropsychology review》2008,18(4):273-286
This selective review examines the lack of an explanation for the sharply increasing prevalence of autism, and the lack of
any synthesis of the proliferating theories of autism. The most controversial and most widely disseminated notion for increasing
prevalence is the measles–mumps–rubella/thimerosal vaccine theory. Less controversial causes that have been proposed include
changes in autism diagnostic criteria, increasing services for autism, and growing awareness of the disorder. Regardless of
its causes, the increasing prevalence of autism has put pressure on the field of autism research to generate productive and
predictive theories of autism. However, the heterogeneity of brain deficits, impaired behaviors, and genetic variants in autism
have challenged researchers and theorists, and despite 45 years of research, no standard causal synthesis has emerged. Research
going forward should assume that autism is an aggregation of myriad independent disorders of impaired sociality, social cognition,
communication, and motor and cognitive skills. 相似文献
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Anja Repalust Stanko Rihtar Aleksandar Štulhofer 《Psychology, health & medicine》2017,22(9):1045-1055
Considering that programmatic data suggest a recent rise in vaccine refusal in Croatia, this study, first of its kind in Southeast Europe, aimed to estimate the prevalence, and sociodemographic, and sociocultural determinants of childhood vaccine refusal and hesitancy (CVRH) intentions among Croatian adults. Multi-stage stratified population-based survey included 1000 individuals aged 18–88 years (Mage = 47.7, SD = 17.8), of whom 51.7% were women. The outcome, a categorical indicator, distinguished among individuals who would approve vaccinating their children (vaccine accepting), those who would approve some but not all vaccines (vaccine hesitant), and those who would refuse vaccination (vaccine refusing). A sizeable minority of participants was characterized by childhood vaccine refusal (10.6%) and hesitancy intentions (19.5%). In a multivariate assessment controlling for parenthood, the odds of vaccine hesitancy were significantly increased by a younger age (AOR = 1.96–3.03, p < .01). Religiosity (AOR = 1.12, p < .05) and the use of alternative medicine (AOR = 2.85, p < .001) increased the odds of vaccine refusal. However, individual characteristics seem to be relatively poor predictors of CVRH intentions in Croatia. Following the social contagion model, future research should move beyond individual-level approach and take into account social interaction and social network effects. 相似文献
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