Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Salt taste detection: an R-index approach to signal-detection measurements

The R-index approach to the signal-detection P(A) index of sensitivity was used to measure taste sensitivity to NaCl solutions. The R-index is the predicted probability of the correct choice of a signal, for a given signal-noise pair. For flow-wise and sipwise presentation, R-indices did not fluctuate significantly, provided subjects could not see the stimuli yet to be presented, indicating a lack of systematic sensitivity drift. The simultaneous measurement of more than one signal strength with reference to a common noise stimulus was seen to be a viable and sensitive procedure. Comparison of flow-wise and sipwise presentation of stimuli using R-indices, indicated that the former elicited greater subject sensitivity to NaCl taste.     

Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent

Mood disorders and chronic stress are frequently associated with gastrointestinal (GI) symptoms including diarrhoea or constipation. Locally produced serotonin [5-hydroxytryptamine (5-HT)] regulates GI motility and is a key factor in the pathophysiology of stress-associated GI disorders. We aimed to establish whether chronic stress can differentially affect faecal output and colon 5-HT concentration in two inbred mouse strains: BALB/c and C57BL/6 which differ in their ability to cope with stress. Adult male BALB/c and C57BL/6 mice were restrained for 2?h daily for 10 days. Defecation was monitored during each stress session. Twenty-four hours after the last session of stress, plasma corticosterone concentration was higher than control in both strains, indicative of a physiological effect of chronic stress; however, stress-induced diarrhoea was more persistent in C57BL/6 mice. Basal concentration of colon 5-HT was higher in C57BL/6 mice, and stress elicited an increase in colon 5-HT only in this strain. Finally, na?ve BALB/c mice had a higher sensitivity (incidence of diarrhoea) to 5-HT (0.33?mg/kg, i.p.) than C57BL/6 mice. Our results suggest that differential defecation responses to stress may be associated with colon 5-HT concentration, which may in turn reflect the individual sensitivity to 5-HT. In addition, C57BL/6 mice emerge as a relevant model for studying GI alterations induced by chronic stress.     

‘Between Rome and Constantinople’: the Italian-Albanian Church: a study in Eastern Catholic history and ecclesiology

This article examines the Eastern Christian presence on the Italian Peninsula and the Island of Sicily; the settlement of Albanian Christians after the Ottoman conquest of the Balkans, the emergence of a distinct Italo-Albanian Church and the jurisdictional arrangements made to accomodate this. Concentrating on the period from the 15th century onwards, from the arrival of large numbers of Eastern Christian Albanians in southern Italy and Sicily, the article examines the unique arrangement between Rome and Constantinople, from the Council of Florence (1439) to the Council of Trent (1545–1563), when the Orthodox Bishop of Ohrid provided ecclesial jurisdiction, an arrangement which has no direct historical parallel. The article highlights the work of the eighteenth-century historian Pietro Pompilio Rodotà (who related the two distinct phases of Eastern Christian presence, for historical, cultural, ethnic and linguistic reasons, to the development of the general category of the ‘Greek Rite’) and more contemporary attempts by some Italo-Albanians to establish a metropolitanate (posing questions for the relationship of the Italo-Greek Monastery of Grottaferrata to any future Italo-Albanian ecclesial body). The history and tradition of the Italian-Albanian Church and of the Monastery of Grottaferrata, present a unique and significant Eastern Christian–Eastern Catholic presence in Italy, raising important questions for ecumenism and ecclesiolgy in Europe today.     

The Vatican and Europe: Political Theology and Ecclesiology in Papal Statements from Pius XII to Benedict XVI

The article examines the origins and evolution of the Vatican's political theology and ecclesiology for Europe from Pius XII (especially after the Second World War) and including the pontificates of John XXIII, Paul VI, John Paul II and Benedict XVI. It seeks to examine the continuities of the ‘Idea of Europe’ in papal thought against a background of changing political context – the end of the Second World War, the Cold War, the fall of the communist state system, the emergence of a united but diverse Europe after 1989. The political structures of the continent now include within its geographic sweep Western and Eastern Christian churches which, divided by tradition and modern history, find their relationship a key marker in the contemporary religious identity of Europe. This reality is a significant framework for Vatican thinking on Europe especially for John Paul II and Benedict XVI.     

Perfectionism, acne and appearance concerns

This study investigated the relationship between perfectionism and two aspects of appearance worry: acne-related concerns and dysmorphic concerns. One-hundred and sixty five female university students completed measures of three facets of perfectionism: self-oriented, other-oriented and socially prescribed [Hewitt, P. L., & Flett, G. L. (1991a). Perfectionism in the self and social contexts: conceptualization, assessment and association with psychopathology. Journal of Personality and Social Psychology, 60, 456–470], general psychopathology (GHQ-28), acne health related quality of life [Girman, C. J., Hartmaier, S., Thiboutot, D., Johnson, J., Barter, B., DeMunro-Mercon, & Waldstreicher, J. (1996). Evaluating health-related quality of life in patients with facial acne: development of a self-administered questionnaire for clinical trials. Quality of Life Research, 5, 481–490] and dysmorphic concerns [Oostuizen, P., Lambert, T., & Castle, D.J. (1998). Dysmorphic concern: prevalence and associations with clinical variables. Australian and New Zealand Journal of Psychiatry, 32, 129–132]. Multiple regression analyses showed that, after controlling for general psychopathology, a high level of socially prescribed perfectionism was associated with a greater tendency to be concerned about acne in particular and appearance in general.     

Vestibular stimulation affects optic-flow sensitivity

Typically, multiple cues can be used to generate a particular percept. Our area of interest is the extent to which humans are able to synergistically combine cues that are generated when moving through an environment. For example, movement through the environment leads to both visual (optic-flow) and vestibular stimulation, and studies have shown that non-human primates are able to combine these cues to generate a more accurate perception of heading than can be obtained with either cue in isolation. Here we investigate whether humans show a similar ability to synergistically combine optic-flow and vestibular cues. This was achieved by determining the sensitivity to optic-flow stimuli while physically moving the observer, and hence producing a vestibular signal, that was either consistent with the optic-flow signal, eg a radially expanding pattern coupled with forward motion, or inconsistent with it, eg a radially expanding pattern with backward motion. Results indicate that humans are more sensitive to motion-in-depth optic-flow stimuli when they are combined with complementary vestibular signals than when they are combined with conflicting vestibular signals. These results indicate that in humans, like in nonhuman primates, there is perceptual integration of visual and vestibular signals.     

Integration of faces and voices, but not faces and names, in person recognition

Recent studies on cross-modal recognition suggest that face and voice information are linked for the purpose of person identification. We tested whether congruent associations between familiarized faces and voices facilitated subsequent person recognition relative to incongruent associations. Furthermore, we investigated whether congruent face and name associations would similarly benefit person identification relative to incongruent face and name associations. Participants were familiarized with a set of talking video-images of actors, their names, and their voices. They were then tested on their recognition of either the face, voice, or name of each actor from bimodal stimuli which were either congruent or novel (incongruent) associations between the familiarized face and voice or face and name. We found that response times to familiarity decisions based on congruent face and voice stimuli were facilitated relative to incongruent associations. In contrast, we failed to find a benefit for congruent face and name pairs. Our findings suggest that faces and voices, but not faces and names, are integrated in memory for the purpose of person recognition. These findings have important implications for current models of face perception and support growing evidence for multisensory effects in face perception areas of the brain for the purpose of person recognition.