ACQUISITION AND FUNCTIONAL ANALYSIS OF MANDING WITH AUTISTIC STUDENTS

Three autistic students were trained to request a specific object from an adult “supplier” with the sentence, “Give me —” and to deliver that object to another adult, the “director.” Subsequently, the degree to which the object offered by the supplier controlled the “Give me —” verbal response was assessed by delivering to the student an object other than the one requested. Despite knowing the names of all objects used in the experiment, students accepted and delivered to the director any object offered by the supplier regardless of its match with the requested object. After training to say “That's not it. Give me —” when nonrequested objects were offered, students responded differentially to requested and nonrequested objects, suggesting control of the “Give me —” response by the requested object, a characteristic of a mand. These results generalized across settings and objects. Results are discussed in terms of the training technique to establish manding and the functional analysis of the resulting verbal behavior.     

Effects of excitotoxic brain lesions on taste-mediated odor learning in the rat

The association learning between taste and odor is important in ingestive behavior. For a better understanding of this learning, we have developed a convenient and useful paradigm to assess the taste-mediated odor learning. In the training session, Wistar male rats drank water from two bottles in their home cages and from eight small glass dishes. In the learning session they were exposed in their home cages and also in a circular open-field apparatus to 0.005 M Na-saccharin and 0.02 M quinine hydrochloride which contained either banana or almond odors. One learning trial consisted of this pair of exposures. The preceding behavioral experiment has shown that these two odors are not aversive and are differentially perceived by rats. In the test session, the animals were put in the open-field apparatus equipped with eight dishes: four contained water with banana, and another four, with almond. Normal control rats preferred to drink water with the odor previously associated with saccharin. Stronger and more persistent preference was attained after two or three learning trials. To elucidate the brain sites responsible for this taste-mediated odor learning, the same procedure was assessed on brain-lesioned rats. Rats with lesions in the amygdala showed rapid extinction of preference to the saccharin-associated odor, whereas control rats did not. However, rats with lesions in the insular cortex showed retention of learning similar to that of the control rats. Rats with lesions in the sulcal prefrontal or cingulate cortices showed moderate disruptive effects on preference to the saccharin-associated odor. In conclusion, the odor learning established in our experimental paradigm is based on the association between the quality of odor and hedonics of taste. The amygdala may play a role in the formation, at least in the retention process, of this taste-odor association learning.     

Effect of an observer's presence on facial behavior during dyadic communication

In everyday life, people communicate not only with another person but also in front of other people. How do people behave during communication when observed by others? Effects of an observer (presence vs absence) and interpersonal relationship (friends vs strangers vs alone) on facial behavior were examined. Participants viewed film clips that elicited positive affect (film presentation) and discussed their impressions about the clips (conversation). Participants rated their subjective emotions and social motives. Durations of smiles, gazes, and utterances of each participant were coded. The presence of an observer did not affect facial behavior during the film presentation, but did affect gazes during conversation. Whereas the presence of an observer seemed to facilitate affiliation in pairs of strangers, communication between friends was exclusive and not affected by an observer.     

Effects of stimulation by three-dimensional natural images on prefrontal cortex and autonomic nerve activity: a comparison with stimulation using two-dimensional images

Empirical evidence suggests that three-dimensional (3D) images of nature promote physiological relaxation in humans by providing more realistic effects compared with two-dimensional (2D) images. However, no studies have evaluated the physiological relaxation effects of nature-derived 3D images on prefrontal cortex and autonomic nerve activity. The present study aimed to clarify the physiological relaxation effects of visual stimulation by 3D flower images on prefrontal cortex and autonomic nerve activity. Nineteen male university students (22.2 ± 0.6 years) were presented with 3D and 2D images of the water lily for 90 s. Prefrontal cortex activity was measured using near-infrared spectroscopy, while autonomic nerve activity was measured using heart rate variability (HRV). Psychological effects were determined using a modified semantic differential method (SD). Compared with visual stimulation by 2D images, that by 3D images resulted in a significant decrease in oxyhemoglobin concentration in the right prefrontal cortex, lower sympathetic activity as calculated by the ratio of the low-frequency to high-frequency HRV component, and a significantly greater realistic feeling as evidenced by higher SD ratings. In conclusion, visual stimulation by realistic 3D floral images promotes physiological relaxation more effectively than the corresponding 2D image.     

Crystal structure of a hexagonal phase and its relation to a quasicrystalline phase in Zn-Mg-Y alloy

The crystal structure of a Zn-Mg-Y hexagonal phase, considered to be related to that of the quasicrystalline phase, has been determined by single-crystal X-ray diffraction. The atomic model, refined to a final R value of 0.027, has the composition Zn65.22Mg27.92Y6.86 and 92 atoms in a unit cell with lattice constants a = 14.579(2) A and c = 8.687(1) A and the space group P63/mmc. The Y atoms are situated at two different sites; one is fully occupied by Y atoms, while the other is shared with Mg atoms. The structure can be characterized by a layer structure stacked along the c axis, and also viewed as a columnar structure composed of fused Friauf polyhedras sharing hexagonal rings. The similarity of this hexagonal phase to the MgZn2 phase is shown. The structural relationship between this hexagonal phase and the icosahedral phase is also discussed.     

The Organization of Extrinsic Neurons and Their Implications in the Functional Roles of the Mushroom Bodies in Drosophila melanogaster Meigen

Although the importance of the Drosophila mushroom body in olfactory learning and memory has been stressed, virtually nothing is known about the brain regions to which it is connected. Using Golgi and GAL4–UAS techniques, we performed the first systematic attempt to reveal the anatomy of its extrinsic neurons. A novel presynaptic reporter construct, UAS-neuronal synaptobrevin–green fluorescent protein (n-syb–GFP), was used to reveal the direction of information in the GAL4-labeled neurons. Our results showed that the main target of the output neurons from the mushroom body lobes is the anterior part of the inferior medial, superior medial, and superior lateral protocerebrum. The lobes also receive afferents from these neuropils. The lack of major output projections directly to the deutocerebrum’s premotor pathways discourages the view that the role of the mushroom body may be that of an immediate modifier of behavior. Our data, as well as a critical evaluation of the literature, suggest that the mushroom body may not by itself be a “center” for learning and memory, but that it can equally be considered as a preprocessor of olfactory signals en route to “higher” protocerebral regions.     

Hierarchical organization of the coordinative structure of the skill of clay kneading

An experiment was conducted to study the skill of clay kneading in pottery. This task usually requires a few years to master and is therefore well suited to study the long-term development of a complex motor skill. Participants' kneading movements were measured in 3D using a motion capture device and phase relations among coordinates and joint angles were analyzed in terms of the mutual phase relative to a reference point using the Hilbert transform. While a certain degree of periodicity was observed in all 10 participants, the behavior of the experts was characterized by a significant delay for the right elbow (i.e., the pushing arm) and the fore-aft position of the upper torso and only brief delays for the other parts, which all tended to synchronize with the reference. These findings are consistent with our notion of "differentiation within coordination", according to which skill learning proceeds in a hierarchical manner in that coordination among limb movements is established first, followed by modulations of specific limb movements within the established coordination. Although this feature of expert behavior was also apparent in our previous studies of clay kneading and samba shaking and dancing, the numbers of participants in those studies were not sufficient to draw firm conclusions. Since the present study involved more participants and a superior method of analysis, the present evidence for the principle of differentiation within coordination is more conclusive.     

Effects of textual prompts and feedback on social niceties of adolescents with autism spectrum disorder in a simulated workplace

Previous research demonstrates the efficacy of behavioral skills training with a textual prompt to establish greetings and conversational skills. This study examined the efficacy of a brief intervention of textual prompts with performance feedback for increasing social niceties of adolescents and young adults with autism spectrum disorder in a simulated workplace. Target social niceties included “Do you have a minute?” when a participant initiated an interaction and “Thank you for your time” when a participant ended the interaction. Results revealed this intervention was effective for 7 of 9 participants. This study expands upon previous studies by showing the efficacy of a resource-efficient training on acquisition and generalization of social niceties by people with autism spectrum disorder.     

Velocity-dependent EMG activity of masseter and sternocleidomastoideus muscles during a ballistic arm thrusting movement

Two experiments were conducted to investigate the functional relationship between the general somatic motor function and the oral motor function. In Experiment 1, we analyzed the relationship between the amount of masseter muscle (MSS) activity and the velocity of a ballistic, 'karate-do' arm thrusting movement (ThrMov). ThrMov velocity was measured from video images taken with a high-speed CCD camera at a frequency of 500Hz. EMGs of MSS and sternocleidomastoideus (SCM) muscles as well as other related muscles were recorded simultaneously with video images in 6 varsity 'karate-do' athletes. Pearson's correlation coefficients were calculated between EMG amplitude and movement velocity. EMG activity of MSS as well as the other muscles increased as a function of ThrMov velocity in all participants, as evidenced by highly significant (p<.01) correlation coefficients, ranging from .64 to .87 (mean: .75). MSS EMG activity attained during ThrMovs performed at maximum velocity ranged between 14.6% and 113.8% of this muscle's MVC (45.7+/-39.3% MVC, mean+/-SD). SCM was also strongly active and closely associated with MSS. Besides changes in amount of EMG activity, it was further found that R-MSS EMG onset progressively shifted to the earlier phase of the ThrMov as ThrMov velocity increased. EMG onset time of R-MSS as well as R- and L-SCMs was negatively correlated with ThrMov velocity; when performed at maximum velocity MSS activation preceded the start of ThrMov by more than 100ms, whereas MSS was recruited last at approximately 150ms after the start of ThrMov when performed at moderate speed ( approximately 50% of maximum). In Experiment 2, the effects of head movement relative to the trunk on R-MSS and SCMs EMG activity were tested in both gazing and sidelong glancing conditions. A much smaller head rotation relative to the trunk was necessary during the ThrMov in the sidelong glancing condition compared to the gazing condition. R-MSS EMG activity was affected significantly by the difference between these conditions and decreased by 5.2% MVC in the sidelong glancing condition compared to the gazing condition. In association with the change in requirement for head movement between those conditions, EMG balance between the bilateral SCMs changed substantially. Finally, marked muscle activity during ThrMov was found in the MSS that was not directly involved in performing this movement, indicating a form of 'remote facilitation'.     

An Optimized Design of Choice Experiments: A New Approach for Studying Decision Behavior in Choice Task Experiments

In this paper, we present a new approach for the optimal experimental design problem of generating diagnostic choice tasks, where the respondent's decision strategy can be unambiguously deduced from the observed choice. In this new approach, we applied a genetic algorithm that creates a one‐to‐one correspondence between a set of predefined decision strategies and the alternatives of the choice task; it also manipulates the characteristics of the choice tasks. In addition, this new approach takes into account the measurement errors that can occur when the preferences of the decision makers are being measured. The proposed genetic algorithm is capable of generating diagnostic choice tasks even when the search space of possible choice tasks is very large. As proof‐of‐concept, we used this novel approach to generate respondent‐specific choice tasks with either low or high context‐based complexity that we operationalize by the similarity of alternatives and the conflict between alternatives. We find in an experiment that an increase in the similarity of the alternatives and an increase in the number of conflicts within the choice task lead to an increased use of non‐compensatory strategies and a decreased use of compensatory decision strategies. In contrast, the size of the choice tasks, measured by the number of attributes and alternatives, only weakly influences the strategy selection. Copyright © 2014 John Wiley & Sons, Ltd.