Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Systems of Care as Asset-Building Communities: Implementing Strengths-Based Planning and Positive Youth Development

Using a strength-based approach is one of the hallmarks of the system of care (SOC) initiative, and is consistent with the foundations of community psychology. However, while strengths-based planning is recommended and child and family teams often list child and family strengths, the care plans often do not incorporate the strengths in strategies and interventions. The research base regarding strength implementation and effectiveness is summarized, and needed research is outlined. Steps are offered for promoting the use of strengths in SOCS. Implementing programs from the field of positive youth development is advocated as a way that the educational and criminal justice systems could be more actively engaged in implementing strength-based strategies in SOCs. Promoting SOCs to focus more attentively to asset-building (at the child, family, and community level) is compatible with a public health model that addresses mental health concerns in the context of a full range of supports and services so that all children might experience good mental health and realize their potential.     

A Conceptual and Empirical Basis for Including Medical Family Therapy Services in Cancer Care Settings

Psychosocial interventions in oncology settings have largely been individually and group-based despite evidence that a family-based approach fills a treatment gap in the cancer care experience. Medical Family Therapists are trained to address the family as the unit of treatment and provide services that consider family dynamics, reorganization of couple and family roles, and broader systemic issues. This article describes the conceptual bases for Medical Family Therapy services provided in cancer care settings, and reviews research on their implementation and effectiveness. Following a review of the literature, recommendations for studying the effectiveness and efficacy of MedFT in cancer care treatment are detailed.     

Relations between physical activity, weight discrepancies, body-cathexis, and psychological well-being in college women

This study examined the relations between physical activity, weight discrepancies, body-cathexis, and indicators of psychological well-being in college women. Factor analysis and zero-order correlation, and partial correlation analyses show that physical activity was not directly related to psychological well-being, however, physical activity did reduce weight discrepancies and improved body-cathexis. When specific body types were examined, there were distinctive patterns of satisfaction with body parts and processes depending on whether the women's body types conformed to or deviated from idealized weights and heights.     

The Analysis of Single-Case Research Data: Current Instructional Practices

Visual analysis is the predominant method of analysis in single-case research (SCR). However, most research suggests that agreement between visual analysts is poor, which may be due to a lack of clear guidelines and criteria for visual analysis, as well as variability in how individuals are trained. We developed a survey containing questions about the content and methods used to teach visual and statistical analysis of SCR data in verified course sequences (VCS) and distributed it via the VCS Coordinator Listserv. Thirty-seven instructors completed the survey. Results suggest that there is variability across instructors in some fundamental aspects of data analysis (e.g., number of effects required for a functional relation) but a great deal of consistency in others (e.g., emphasizing visual over statistical analysis). We discuss our results along with their implications both for teaching students to analyze SCR data and for conducting additional research on behavior-analytic training programs.