A longitudinal study of pain sensitivity and blood pressure in adolescent boys: results from a 5-year follow-up.

A growing literature has observed a significant reduction in pain sensitivity among hypertensive animals and humans. It is uncertain whether a reduced sensitivity to pain can be observed in nonnotensive individuals who go on to develop high blood pressure. Blood pressure (BP) was reassessed in one hundred fifteen 19-year-old boys initially tested at age 14, when they were also presented with a pain stimulus (mechanical finger pressure). Hierarchical regression analyses indicated that information regarding pain tolerance improved prediction of changes in systolic and diastolic blood pressure beyond that afforded by differences in BP at age 14, parental history of hypertension, and body mass index. These analyses suggest that pain sensitivity may be associated with physiological processes involved in the development of sustained high blood pressure.     

赵汀阳教授访谈录——联合国大学“全球正义”访谈系列

让-马克·夸戈（Jean—Marc Coicaud）,法国哲学家,联合国大学教授,主持联合国大学的“全球正义”的系列思想访谈节目,与各国的知名学者对话,讨论前沿思想问题,网上直播。夸戈教授在联合国工作期间任联合国前秘书长加利的助手。本访谈有文字访谈与视频访谈两个版本,内容大部分一致,但视频版由于时间关系有部分问题没有讨论到,例如民主问题。这里是文字访谈的完整版。     

Muscimol diffusion after intracerebral microinjections: a reevaluation based on electrophysiological and autoradiographic quantifications

Intracerebral muscimol injection is widely used to inactivate discrete brain structures during behavioral tasks. However, little effort has been made to quantify the extent of muscimol diffusion. The authors report here electrophysiological and autoradiographic results obtained after muscimol injection (1 microg/microl) either into the nucleus basalis magnocellularis (0.1-0.4 microl) or into the thalamic reticular nucleus (RE, 0.05-0.1 microl). In 52 rats, multiunit recordings were collected either in the RE or in the auditory thalamus during the 2 h following muscimol injection. Decreases in neuronal activity were observed up to 3 mm from the injection site; their time of occurrence was a function of the distance between the injection and recording sites. Because these decreases cannot be explained by physiological effects, they likely reflected muscimol diffusion up to the recording sites. Autoradiographic studies involved 25 rats and different experimental conditions. Optical density (OD) measures indicated that after a survival time of 15 min, a 0.05 microl injection produced a labeled area of 5.25 mm(2) at the injection site and a rostrocaudal labeling of 1.7 mm. Increasing the survival time to 60 min, or increasing the injected volume to 0.1 microl, systematically led to a larger labeled area at the injection site (8-12 mm(2)) and to a larger rostrocaudal diffusion (2.0-2.5 mm). Direct quantifications of radioactivity by a high-resolution radioimager validated the OD measures and even indicated a larger muscimol diffusion (up to 3.25 mm). Thus, these data point out that muscimol diffusion after intracerebral microinjection is larger than usually supposed. The relationships between these results and those obtained in behavioral studies are discussed.     

Psychotherapy across languages: beliefs,attitudes and practices of monolingual and multilingual therapists with their multilingual patients

Aims: The present study investigates beliefs, attitudes and practices of 101 monolingual and multilingual therapists in their interactions with multilingual patients. Method: A mixed‐method approach was adopted using an online questionnaire with closed questions, and informed questions in interviews with one monolingual and two multilingual therapists. Results: A principal component analysis yielded a four‐factor solution accounting for 41% of the variance. The first dimension, which explained 17% of variance, reflects therapists' attunement towards their bilingual patients (attunement versus collusion). Further analysis showed that the 18 monolingual therapists differed significantly from their 83 bi‐ or multilingual peers on this dimension. The follow‐up interviews confirmed this result. Discussion: Recommendations based on these findings are made for psychotherapy training and supervision.     

Languages on the screen: Is film comprehension related to the viewers’ fluency level and to the language in the subtitles?

This research aimed at studying the role of subtitling in film comprehension. It focused on the languages in which the subtitles are written and on the participants' fluency levels in the languages presented in the film. In a preliminary part of the study, the most salient visual and dialogue elements of a short sequence of an English film were extracted by the means of a free recall task after showing two versions of the film (first a silent, then a dubbed-into-French version) to native French speakers. This visual and dialogue information was used in the setting of a questionnaire concerning the understanding of the film presented in the main part of the study, in which other French native speakers with beginner, intermediate, or advanced fluency levels in English were shown one of three versions of the film used in the preliminary part. Respectively, these versions had no subtitles or they included either English or French subtitles. The results indicate a global interaction between all three factors in this study: For the beginners, visual processing dropped from the version without subtitles to that with English subtitles, and even more so if French subtitles were provided, whereas the effect of film version on dialogue comprehension was the reverse. The advanced participants achieved higher comprehension for both types of information with the version without subtitles, and dialogue information processing was always better than visual information processing. The intermediate group similarly processed dialogues in a better way than visual information, but was not affected by film version. These results imply that, depending on the viewers' fluency levels, the language of subtitles can have different effects on movie information processing.     

The neurocognition of conduct disorder behaviors: specificity to physical aggression and theft after controlling for ADHD symptoms

There is growing evidence that among the different conduct disorder (CD) behaviors, physical aggression, but not theft, links to low neurocognitive abilities. Specifically, physical aggression has consistently been found to be negatively related to neurocognitive abilities, whereas theft has been shown to be either positively or not related to neurocognition. The specificity of these links needs further examination because attention deficit hyperactivity disorder (ADHD) links to both physical aggression and neurocognitive variation. The development of self-reported physical aggression and theft, from age 11 to 17 years, was studied in a prospective at-risk male cohort via a dual process latent growth curve model. Seven neurocognitive tests at age 20 were regressed on the growth parameters of physical aggression and theft. The links between neurocognition and the growth parameters of physical aggression and theft were adjusted for ADHD symptoms at ages 11 and 15 (parent, child and teacher reports). Results indicated that verbal abilities were negatively related to physical aggression while they were positively associated with theft. However, inductive reasoning was negatively associated with increases in theft across adolescence. Symptoms of ADHD accounted for part of the neurocognitive test links with physical aggression but did not account for the associations with theft. These differences emphasize the importance of examining specific CD behaviors to better understand their neurodevelopmental mechanisms. They also suggest that youth who engage in different levels of physical aggression or theft behaviors may require different preventive and corrective interventions.