Episodic memory effects of gamma frequency precuneus transcranial magnetic stimulation in Alzheimer's disease: A randomized multiple baseline study

Episodic memory decline is the prominent neuropsychological feature of typical Alzheimer's Disease (AD), for which current treatments have a limited clinical response. Recently, gamma entrainment therapy has been used as a non-invasive treatment in AD, providing evidence that it may have the potential to alleviate brain pathology and improve cognitive function in AD patients. At the same time, the precuneus (PC) has been recognized as a key area involved in AD related memory deficits and as a key node of the Default Mode Network. This study aimed to investigate the effectiveness of a 40 Hz Transcranial Magnetic Stimulation (TMS) intervention, delivered bilaterally to the precuneus for 10 days, in improving the patients' episodic memory performance. Secondary outcome variables investigated included general cognitive function, semantic and spatial memory, as well as attention and executive function. A concurrent multiple baseline design across five cases was employed. Four patients completed the study. Visual analysis combined with effect size indices were used to evaluate changes across phases. An increase in the average level of immediate recalled words was observed in three out of four patients. Effect size indices indicated significant improvement of attention skills in two patients. No treatment effect was observed for semantic and visual memory, or for executive function. An immediate treatment effect was observed in all patients' general cognitive function as assessed with the Alzheimer's Disease Assessment Scale (mean reduction of 5 points), which was maintained and improved further three months post-treatment. The neuropsychological evaluations indicated improved performance three months post-treatment in immediate and delayed recall, attention, phonological verbal fluency, anxiety, and neuropsychiatric symptoms. This study provides preliminary evidence for the efficacy of a novel non-pharmacological treatment using gamma-band TMS in addressing cognitive dysfunction in AD.     

Is a false belief statement a lie or a truthful statement? Judgments and explanations of children aged 3 to 8

Attribution of a false belief is usually taken to indicate that children distinguish between a real world state of affairs and its representation by a subject. But how do they conceive of the properties of such a mental entity? Do they understand that false belief necessarily goes hand in hand with good faith? Our study explores to what extent children conflate false beliefs with lies. Sixty children aged 3 to 8 were presented with an FB situation and then asked whether the character having an FB was lying or not. Results show that up to 6 years, although correctly attributing the FB, children systematically judge the FB statement to be a lie, since it does not correspond to the real world state of affairs. Older children succeed in the lie judgment, invoking the false believer's not knowing the world state. Discussion bears on the relation between false belief and more general epistemic states.     

Links between relational aggression,parenting and personality among adolescents

The aim of this cross-sectional study was to examine the mediating role of behavioral inhibition system, referring to the inhibition of behavior, and behavioral activation system (BAS), related to impulsivity, in the association between perceived parenting behaviors and relational aggression. It simultaneously investigated the moderating effects of callous-unemotional (CU) traits in this association in a sample of 261 (127 girls) Greek junior high school students who completed a self-report questionnaire. Results of the mediation analyses revealed that BAS was a partial mediator in the relationship between low parental psychological autonomy and relational aggression, as well as between low parental behavioral control and relational aggression. The effect of low parental psychological autonomy on relationally aggressive behavior was also significantly stronger when CU traits were present (moderator). The results emphasize that both individual and interpersonal factors should be taken into consideration when studying relational aggression.     

处于现代主义-后现代主义争论框架之中的"合理性"和"多种合理性"

价值判断的对象并不仅仅包括各种行为方式,[1]也包括各种语词。“合理性的”这个术语是这样一个语词:具有了合理性的就是善的。在刚刚过去的几十年间,作为对所谓的“西方的合理性”的某种反动,人们之所以开始谈论“多种合理性”———这是一种特别被后现代主义者提出的主张,很可能原因就在于此。在这里,我并不打算详细论述导致这样一种主张出现的各种历史发展。我只想使自己限于———在与这次学术讨论的主题有关的各种概念所具有的学术框架之内———详细考察这些概念:这种框架就是现代主义—后现代主义争论。作为与“古代”、“传统”、“…     

The Relational aggression scale (RAS): Psychometric properties of a newly developed measure of relational aggression

Introduction

Relational aggression (RA) is a growing and worrisome problem, particularly among adolescents, that can result in negative psychological consequences for those involved. Therefore, it is important to develop instruments to detect these incidents and understand the problem so as to design effective intervention strategies.

Different action patterns for cooperative and competitive behaviour

The aim of the present study is to elucidate the influence of context on the kinematics of the reach-to-grasp movement. In particular, we consider two basic modes of social cognition, namely cooperation and competition. In two experiments kinematics of the very same action - reaching-to-grasp a wooden block - were analyzed in two different contexts provided by a cooperative task and competitive task. For the 'cooperation' tasks two participants were required to reach and grasp their respective objects and to cooperate to join the two objects in specific configurations in the middle of the working surface. For the 'competition' tasks, the two participants had to compete to place their own object first in the middle of the working surface. Results revealed specific kinematic patterns for cooperation and competition which were distinct from similar actions performed by each participant in isolation. Further, during the cooperation tasks, a high level of correlation between key kinematical parameters of the two participants was found. In accordance with evidence from neuroimaging, developmental and social psychology our results suggest the existence of motor patterns which reflect the intention to act in a social context.     

Expanding the evidence: Developments and innovations in clinical practice,training and competency within voice and communication therapy for trans and gender diverse people

Background: Speech and language therapists (SLTs) deliver voice and communication therapy for trans and gender diverse people to facilitate authentic vocal and communicative expression. Davies, Papp, and Antoni (2015) have provided a comprehensive review of the literature, with recommendations for good clinical care. Several areas highlighted as gaps in the research were identified by the current authors as ones in which evidence is expanding.

Aims: To demonstrate 1) an expansion of the evidence base in particular innovations in voice group therapy for trans women and trans men; 2) the importance of delivering voice and communication therapy as part of a complete approach to trans and gender diverse health care; and (3) developments in training and competency in the UK.

Method: Data were drawn from three small-scale projects, two surveys, and one audit.

Measurements: Data from survey and audits and pre- and post-group acoustic measures of and client self-perceptual measures, including the Transsexual Voice Questionnaire (TVQ^MtF); a client-generated set of questions for trans men; and the migration of vocal identity map, adapted from Narrative Therapy practices.

Results: Positive outcomes for both pitch measures and client perception were recorded. Audit and survey data provided evidence of developments in training and competency in the UK.

Conclusion: Evidence supports group therapy as a successful approach for trans individuals across a number of parameters of voice and self-perception. Voice group protocols for both trans men and trans women should take account of the social context within which to explore relational presence and authentic voice. SLTs within gender identity clinics provide voice and communication as part of a broader pathway of care, alongside sharing professional knowledge and skills. Current UK developments are documented as indicators of positive responses to the growth in the number of SLTs seeking to develop specialist skills within this field.