Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Enhanced priming for trauma-related material in posttraumatic stress disorder

Intrusive reexperiencing in posttraumatic stress disorder (PTSD) has been linked to perceptual priming for trauma-related material. A prospective longitudinal study (N = 69) investigated perceptual priming for trauma-related, general threat, and neutral words in assault survivors with and without PTSD, using a new version of the word-stem completion task. Survivors with PTSD showed enhanced priming for trauma-related words. Furthermore, priming for trauma-related words measured soon after the trauma was associated with subsequent PTSD severity at 3, 6, and 9 months. The enhanced priming effect was specific to trauma-related words. Enhanced perceptual priming for traumatic material appears to be one of the cognitive processes operating in PTSD.     

Unwanted memories of assault: what intrusion characteristics are associated with PTSD?

Intrusive memories are common in the immediate aftermath of traumatic events, but neither their presence or frequency are good predictors of the persistence of posttraumatic stress disorder (PTSD). Two studies of assault survivors, a cross-sectional study (N=81) and a 6-month prospective longitudinal study (N=73), explored whether characteristics of the intrusive memories improve the prediction. Intrusion characteristics were assessed with an Intrusion Interview and an Intrusion Provocation Task. The distress caused by the intrusions, their "here and now" quality, and their lack of a context predicted PTSD severity. The presence of intrusive memories only explained 9% of the variance of PTSD severity at 6 months after assault. Among survivors with intrusions, intrusion frequency only explained 8% of the variance of PTSD symptom severity at 6 months. Nowness, distress and lack of context explained an additional 43% of the variance. These intrusion characteristics also predicted PTSD severity at 6 months over and above what could be predicted from PTSD diagnostic status at initial assessment. Further predictors of PTSD severity were rumination about the intrusive memories, and the ease and persistence with which intrusive memories could be triggered by photographs depicting assaults. The results have implications for the early identification of trauma survivors at risk of chronic PTSD.     

The Creative Imagination of the Sufi Mystic, Ibn ‘Arabi

The 12^th–13^thcentury mystic, Ibn 'Arabi, was known as the Greatest Master among the Sufis. His insights into dreams, visions and prophetic processes may prove enlightening to our own more secular age. The findings of Carl Jung parallel some of the revelations of the mystic, but Ibn 'Arabi goes farther than Jung into the Active Imagination as both conscious—willed—and spontaneous, autonomous process. Through surrender and annihilation in the Divine, the mystic opens himself to receive theophanies, resulting in a life lived perpetually in awareness of Divine Presence. Union with the Divine is the aim of the mystic and Ibn 'Arabi shows us a detailed account of how that life is experienced.     

Recovery and Renewal: Journey of Hope to the Gulf Coast

When a group of 20 college students and seven adult leaders traveled to the Gulf Coast to repair houses damaged by Hurricane Katrina, they did not realize the multiple ways that they themselves would be renewed. Finding God in the struggle, celebrating diversity, and living with gratitude became the result that subtly changed many lives. Fredrica R. Halligan, Ph.D. is a spiritually-oriented clinical psychologist. She is currently Director of the Counseling Center at Western Connecticut State University and author of Listen Deeply to God: Exploring Spirituality in an Interreligious Age.     

A Longitudinal Investigation of Children’s Trauma Memory Characteristics and Their Relationship with Posttraumatic Stress Disorder Symptoms

Research on Child and Adolescent Psychopathology - While trauma memory characteristics are considered a core predictor of adult PTSD, the literature on child PTSD is limited and inconsistent. We...     

The Protective Effect of Neighbourhood Collective Efficacy On Family Violence and Youth Antisocial Behaviour in Two South Korean Prospective Longitudinal Cohorts

Research on Child and Adolescent Psychopathology - Neighbourhood collective efficacy has been proposed as a protective factor against family violence and youth antisocial behaviour. However, little...     

Spatial cognition: evidence from visual neglect

Recent work on human attention and representational systems has benefited from a growing interplay between research on normal attention and neuropsychological disorders such as visual neglect. Research over the past 30 years has convincingly shown that, far from being a unitary condition, neglect is a protean disorder whose symptoms can selectively affect different sensory modalities, cognitive processes, spatial domains and coordinate systems. These clinical findings, together with those of functional neuroimaging, have increased knowledge about the anatomical and functional architecture of normal subsystems involved in spatial cognition. We provide a selective overview of how recent investigations of visual neglect are beginning to elucidate the underlying structure of spatial processes and mental representations.     

Influence of Age and Sex on Line Bisection: A Study of Normal Performance with Implications for Visuospatial Neglect

ABSTRACT

Line bisection is an established clinical task used to diagnose visuospatial neglect. To date, few studies have considered the extent to which age and sex as background variables contribute to bisection performance. Both variables affect the neural substrates underlying cognitive processes and hence the behavioural performance of bisection. The purpose of this study was to examine the effects of age and sex on normal bisection performance, using three different line lengths to elucidate the influence of these potential contributing factors. Seventy men and 70 women, divided equally into seven age-cohorts between 14 and 80 years, bisected lines. Results indicated clear age- and sex-related differences both in the magnitude and direction of bisection deviations across the three line lengths. Differences are discussed in terms of neural changes across the adult lifespan including hemispheric differences and hormonally mediated changes.     

Development and Validation of the Constructivist Supervisor Scale

The purpose of this research was to develop an instrument for assessing constructivist counselor supervision practices. In an exploratory mode, we also tested supervisee preferences regarding constructivist supervision. Items consistent with constructivist supervision were developed based on a thorough review of the literature and rated by experts in constructivist supervision. Counselors currently receiving supervision (n = 308, 81% female) responded to these items, indicating the extent to which their current or most recent supervisor adhered to these constructivist practices during supervision. Principal components analysis results revealed three main components of constructivist supervision practice: warm and nondirective relationship, past and present experiences, and acceptance of various styles. Preliminary evidence for internal consistency, test–retest reliability, and convergent and discriminant validity of the scale items are reported. Participants also indicated the degree to which they preferred their supervisors’ constructivist practices. The final version of the constructivist supervisor scale, consisting of 29 items, may be used in future research focused on supervision processes as well as in practice to assess the degree to which these core constructivist methods are used during supervision.