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1.
11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catalyses the interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone, thus regulating glucocorticoid access to intracellular receptors. In rats, chronic glucocorticoid excess or stress increases 11beta-HSD-1 in the hippocampus, producing suggestions that it may attenuate the deleterious effects of chronic glucocorticoid excess. However, 11beta-HSD-1 predominantly catalyses 11beta-reduction in the intact liver and hippocampal cells, thus regenerating active glucocorticoids from inert substrate. We studied 11beta-HSD activity in the tissues of male tree shrews following 28 days of sustained psychosocial stress or exogenous administration of cortisol. In the hippocampus, chronic psychosocial stress attenuated 11-HSD-1 activity (69 +/- 9% of control), whereas cortisol alone had no effect. In the liver, both chronic stress and cortisol administration decreased 11beta-HSD-1 activity (47 +/- 11% and 49 +/- 4% fall, resp.). Attenuation of 11beta-HSD-1 within tissues may reflect a homeostatic mechanism designed to minimise the adverse effects of prolonged stress and/or glucocorticoid excess.  相似文献   
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Americans have been gaining weight in recent decades, prompting widespread concern about the health implications of this change. Governments, health practitioners, and the general public all want to know: What is the best way to reduce the health risks associated with higher body weight? The dominant weight‐loss solution to this “obesity problem” encourages individuals to lose weight through behavior change. This solution rests on the assumptions that higher body weight causes health problems, that permanent weight loss is attainable, and that weight loss improves health. But comprehensive reviews of the scientific evidence find mixed, weak, and sometimes contradictory evidence for these premises. We suggest that a different solution to the “obesity problem” is needed – a solution that acknowledges both the multifaceted nature of health and the complex interaction between person and situation that characterizes the connection between weight and health. Thus, we use the lens of social psychological science to propose an alternative, well‐being solution to the “obesity problem”. This solution has the potential to improve health by encouraging eating and exercising for optimal health rather than weight loss, by developing interventions to reduce weight stigma and discrimination, and by helping higher body‐weight people cope with the stress of stigma and discrimination.  相似文献   
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Criminal activities account for a major proportion of the social costs related to illicit drug use. This article examines the factors contributing to property crime activity among a community sample of 653 untreated regular illicit opiate users in 5 Canadian cities (OPICAN study). Multivariate analyses showed the frequency of heroin, cocaine, and crack use, gender, housing status, and past criminal justice involvement as predictors of property crime. Furthermore, crack use had a significantly different impact on property crime depending on housing status and city. These findings underline the need for targeted intervention efforts toward a reduced crime burden.  相似文献   
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Based on a sample of incarcerated women in Quebec prisons in 1989, this study focuses on drug use and abuse and its relation to crime with a special concern for age of onset, nature of conviction, previous involvement in criminal activities, motivation, and other related variables. The emerging profile of these subjects is one of drug‐related problems rather than a deep involvement in criminality. Within this population of women prisoners a strong link between drugs and crime is still difficult to establish. In conclusion, it is suggested that future research rely more on qualitative analyses to gather a better understanding of the operating processes.  相似文献   
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To update and expand Rubey and McIntosh's (1996) survivors of suicide support groups report, SPAN USA completed a survey of U.S. support group leaders (n = 100; 24% completion). There are now more survivor groups (from 280 to 417), and the majority of groups now have a survivor leader (78% vs. 25%). Groups continue to be small (88% < 10 members per session) and meet on a monthly basis (55%). Sharing continues to be a universal experience in groups, which tend to be open‐ended (85%). Current groups are newer, and more operate without a sponsor. Further research is needed to examine group member perspectives and effectiveness of groups.  相似文献   
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In this article, the concept of “media lifestyles” is adopted in order to develop a comprehensive approach toward youth engagement in communication media. We explore how 503 Dutch eighth grade students with full access to new technology combine a broad range of media by focusing on their engagement with media while taking various contexts of use into account. Four different media lifestyles of media omnivores, networkers, gamers, and low‐frequency users are described. Furthermore, we show how the methodology we used is able to provide more insight into how the distinguished media lifestyles were codetermined by particular media, functions and social contexts. Finally, the implications for the Uses & Gratifications theory are discussed.  相似文献   
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Research on racial prejudice is currently characterized by the existence of diverse concepts (e.g., implicit prejudice, old-fashioned racism, modern racism, aversive racism) that are not well integrated from a general perspective. The present article proposes an integrative framework for these concepts employing a cognitive consistency perspective. Specifically, it is argued that the reliance on immediate affective reactions toward racial minority groups in evaluative judgments about these groups depends on the consistency of this evaluation with other relevant beliefs pertaining to central components of old-fashioned, modern, and aversive forms of prejudice. A central prediction of the proposed framework is that the relation between "implicit" and "explicit" prejudice should be moderated by the interaction of egalitarianism-related, nonprejudicial goals and perceptions of discrimination. This prediction was confirmed in a series of three studies. Implications for research on prejudice are discussed.  相似文献   
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This qualitative study aimed to comprehend how mothers experienced and built their maternal identity throughout their lives. Thirty-eight semi-structured interviews were conducted with drug-using and law-breaking mothers. Results showed that three events were significant for participants: pregnancies, loss of custody, and incarceration. As each event challenged their maternal identity, they questioned their substance use and their criminal involvement. Our results suggest that these events represent key moments to encourage their growing awareness and to foster changes in their deviant lifestyle. We conclude this article by discussing interventions possible for each of these important moments in these mothers’ lives.  相似文献   
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