Lesions of the basal ganglia, thalamus, and deep white matter: Differential effects on language functions

Forty-five patients with unilateral demarcated vascular lesions in the basal ganglia, the thalamus and the deep white matter were investigated with an "aphasia battery." Patients with basal ganglia lesions performed worse than both other groups in tests of articulation, syntax, and lexical functions. The deficit of patients with basal ganglia lesions on all expressive language modalities was lateralized to the left hemisphere. Patients with left thalamic lesions showed impairments of speech fluency and in the Token Test. Patients with white matter lesions alone showed no effect of laterality in tests of language functions. The results are discussed on the basis of a recent theory of the participation of the deep nuclei in language processing.     

Semantic gender assignment regularities in German

Gender assignment relates to a native speaker's knowledge of the structure of the gender system of his/her language, allowing the speaker to select the appropriate gender for each noun. Whereas categorical assignment rules and exceptional gender assignment are well investigated, assignment regularities, i.e., tendencies in the gender distribution identified within the vocabulary of a language, are still controversial. The present study is an empirical contribution trying to shed light on the gender assignment system native German speakers have at their disposal. Participants presented with a category (e.g., predator) and a pair of gender-marked pseudo-words (e.g., der Trelle vs. die Stisse) preferentially selected the pseudo-word preceded by the gender-marked determiner "associated" with the category (e.g., masculine). This finding suggests that semantic regularities might be part of the gender assignment system of native speakers.     

Spatio-temporal working-memory and short-term object-location tasks use different memory mechanisms

Spatial short-term memory for objects' locations was investigated in a spatial relocation task. During maintenance, dynamic visual noise or spatial tapping were administered as visual or spatial secondary tasks, respectively. Because memory for location should tap the visual component of working memory, a visual but not a spatial secondary task should impair location memory. In fact, neither of the tasks impaired memory (Experiment 1), although the expected dissociation between visual and spatial components was clearly confirmed for a spatio-temporal main task (Corsi test) (Experiment 2). We then contrasted location memory for pictures of objects and of nonsense figures under visual interference. Real objects were relocated much better than nonsense figures, and visual noise was again ineffective (Experiment 3). When spatial tapping was combined with the same material (Experiment 3a), again no influence on memory for locations of objects was observed and only a small influence on remembering nonsense figures. We suggest that the Corsi and the relocation VSWM-tasks use different memory mechanisms. The configuration of objects is reconstructed from perceptual records in an episodic buffer, provided by the same structures that enable visual memory after longer intervals. Rehearsal is not necessary for the persistence of these traces. In contrast, in the Corsi task remembering, a temporal sequence across homogeneous locations needs spatio-temporal marking and therefore active rehearsal of the locations by shifting spatial attention. A spatially demanding secondary task during retention interrupts this rehearsal.     

The Development of Internal State Language during the Third Year of Life: A Longitudinal Parent Report Study

Children's talk about the mind has been scarcely studied in non‐English speakers. For this reason, this longitudinal study documents age‐related changes in German‐speaking children's internal state language. At 24, 30 and 36 months, children were administered general language tests and their internal state vocabulary levels were obtained via parental report. The developmental transition from a vocabulary rich in physiological, perceptual and desire terms to a vocabulary rich in a wider range of mental concepts confirmed previous research with French‐speaking and English‐speaking children and research in children's internal state comprehension. Further, children's category scores proved to be developmentally stable. Finally, with increasing age, children's category scores became more specifically related to each other, independent of general language skills. The results are discussed in regard to the universality of children's talk about the mind. Copyright © 2012 John Wiley & Sons, Ltd.     

Neurocognitive Performance in Children with ADHD and OCD

Attention-deficit/hyperactivity Disorder (ADHD) and obsessive–compulsive disorder (OCD) have both been linked to dysfunction in the cortico-striato-thalamo-cortical circuitry (CSTCC). However, the exact nature of neurocognitive deficits remains to be investigated in both disorders. We applied two neuropsychological tasks that tap into different functions associated with the CSTCC, namely a serial reaction time (SRT) task, developed to assess implicit sequence learning, and a delay aversion (DA) task in order to assess abnormal motivational processes. The performance data of boys with ADHD (n = 20), OCD (n = 20) and healthy controls (n = 25), all aged 10–18 years, were compared. Subjects with ADHD less frequently chose the larger, more delayed reward compared to those with OCD and controls, while subjects with OCD showed impaired implicit learning. In contrast, the ADHD group was unimpaired in their implicit learning behavior and the OCD group was not characterized by a DA style. Within the OCD-group, severity of obsessions was associated with implicit learning deficits and impulsive symptoms with DA in the ADHD-group. This double dissociation highlights the distinct cognitive dysfunctions associated with ADHD and OCD and might possibly point to different neural abnormalities in both disorders.     

Out of Sight Is Not Out of Mind: Developmental Changes in Infants' Understanding of Visual Perception During the Second Year

Three experiments investigated 14-, 18-, and 24- month-old infants' understanding of visual perception. Infants viewed films in which a protagonist was either able to view the location of a hidden object (Visual Access condition) or was blindfolded when the object location was revealed (No Visual Access condition). When requested to find the object, the protagonist pointed either at the correct location or at the incorrect location. Across experiments, 18-month-olds looked longer at the unexpected action (e.g., person pointing at the incorrect location in the Visual Access condition). By 24 month of age, infants could infer the correct search behavior from gaze alone. These findings suggest that by the middle of the second year of life, infants understand the psychological relation between an observer and an object, even if the object is no longer visible.     

A specific calculating ability

We report two experiments that investigate the calculating strategy used by a low IQ savant to identify prime numbers. Hermelin and O'Connor (1990) had suggested previously that this subject may use a procedure first described by Eratosthenes to detect a prime number, namely, dividing a target number by all primes up to the square root of the target number and testing for a remainder. In the first experiment, we compare the reaction times of the savant to decide whether a number is prime with those of a control subject proficient in mathematical calculation. In addition, we measured the savant's speed of information processing using an inspection time task. We found that the reaction times of the savant, although generally faster, followed the same pattern of the control subject who reported using the Eratosthenes procedure. The savant's inspection time indicated that his speed of processing was far superior to that expected from someone of his IQ. In the second experiment, we measured the time it takes mathematics students to divide by different prime numbers and we also tested them on the prime identification task. We used their division times to simulate their performance on the prime number identification task under the assumption that they used the Eratosthenes procedure. We also simulated the reaction times that would result from a simple memory-based procedure for identifying primes. We found that the Eratosthenes simulation, in contrast to the memory simulation, provided a good fit to both the students' and the savant's reaction times. We conclude that the savant is using a complex computational algorithm to identify primes and suggest two explanations of how the apparent contradiction between his low general intelligence and his superior numerical ability might be resolved.     

Like mother,like child? Maternal determinants of children's early social-emotional development

Social-Emotional competencies evolve early in life. For example, early emotion regulation is learned primarily in the context of mother–child interaction, which may allow for maternal influences to shape children's social-emotional development. The aim of the current study was to longitudinally examine maternal determinants of children's early social-emotional development in a community-based sample of first-time mothers (N = 61, aged 22–39 years). Specifically, we used structural equation modeling to examine how maternal emotion regulation difficulties and subclinical depression directly and indirectly, through sensitivity and postnatal bonding, assessed at 6 to 8 months predicted child outcomes at 12 to 16 months. We found that mothers’ sensitivity predicted fewer social-emotional and behavioral problems and that stronger bonding predicted fewer problems and more social-emotional competencies. Emotion regulation difficulties were significantly associated with depressive symptoms; yet, when accounting for shared variances, both factors differentially predicted less positive child outcomes such that more difficulties indirectly, through poorer bonding, predicted greater delay in competencies, and more symptoms indirectly, through less sensitivity, predicted more problems. Current findings underline the significance of maternal factors impacting the quality of mother–child interaction for children's positive development. Potential implications for early prevention programs to support children who are otherwise at risk for negative emotional outcomes due to mothers’ emotional state postpartum are discussed.     

Making Sense of Interlevel Causation in Mechanisms from a Metaphysical Perspective

According to the new mechanistic approach, an acting entity is at a lower mechanistic level than another acting entity if and only if the former is a component in the mechanism for the latter. Craver and Bechtel (Biol Philos 22(4):547–563, 2007. doi: 10.1007/s10539-006-9028-8) argue that a consequence of this view is that there cannot be causal interactions between acting entities at different mechanistic levels. Their main reason seems to be what I will call the Metaphysical Argument: things at different levels of a mechanism are related as part and whole; wholes and their parts cannot be related as cause and effect; hence, interlevel causation in mechanisms is impossible. I will analyze this argument in more detail and show under which conditions it is valid. This analysis will reveal that interlevel causation in mechanisms is indeed possible, if we take seriously the idea that the relata of the mechanistic level relation are acting entities and accept a slightly modified notion of a mechanistic level that is highly plausible in the light of the first clarification.     

Assessment of Score Dependability of the Wisconsin Schizotypy Scales Using Generalizability Analysis

To investigate the reliability of the Wisconsin Schizotypy Scales, this study applied generalizability analysis with two college student samples who completed the scales at two time points. The results indicated that the Revised Social Anhedonia Scale had acceptable levels of score dependability, but that the score dependability for the other scales (the Physical Anhedonia Scale, the Perceptual Aberration Scale, and the Magical Ideation Scale) was below an acceptable level of .80. The patterns of variance components suggested that the scales’ items need improvement. Researchers can use the included tables to choose the number of items and occasions needed to get dependable score interpretations.