Teaching children with autism spectrum disorder to ask “where” questions using a speech-generating device

Children with autism spectrum disorder (ASD) who have limited speech are often taught to communicate using a speech-generating device (SGD). We evaluated procedures for teaching a mand for information (i.e., Where is [item]?) using an interrupted behavior chain procedure. In Experiment 1, all participants (3 children with ASD who communicated using an SGD) acquired the target mand but transfer to a novel stimulus did not occur. In the second experiment, 2 participants were taught to approach alternative communication partners when the first partner did not provide the information. The second experiment also included procedures to test whether the responses were under the control of appropriate motivating operations (MOs). Generalization across communication partners occurred with both participants, but transfer across behavior chains with only 1 participant. The results of both experiments suggest that teaching multiple behavior chains and evaluating MO control may be necessary to establish generalized manding for information.     

Perceptual sensitivity to dimensional and similarity relations in free and rule-governed classifications

Two experiments were conducted to investigate the perceptual primacy of dimensional and similarity relations in the stimulus classifications of younger and older subjects. In Experiment 1, 4- and 10-year-olds were given free classifications in which they could group stimuli according to overall similarity or identities in size, color, or orientation. Both age groups classified stimuli most frequently according to identities on separate dimensions. In Experiment 2, 4-year-olds and adults were given free classifications followed by rule-governed classifications which required them to group stimuli according to specific relations. In the free classifications, a majority of subjects in both age groups classified the stimuli most frequently according to identities on separate dimensions. In the rule-governed classifications, both age groups were more accurate when a single separate relation was required for solution than when overall similarity was required. These results support a differential-sensitivity view of perceptual development, which asserts that individuals at all ages primarily perceive and use separate relations.     

Conditioned taste aversions support drug discrimination learning at low dosages of morphine.

The present experiment shows that a conditioned taste aversion procedure can support discrimination learning at dosages of morphine comparable to those required to produce motivational effects. Sprague-Dawley rats were injected with 4.0 mg/kg morphine sulfate prior to a saccharin-lithium chloride pairing, and physiological saline prior to a saccharin-saline pairing. The rats avoided the saccharin solution following the administration of morphine and consumed significantly more saccharin following saline administration after four discrimination cycles. After this initial discrimination the subjects were trained with progressively lower doses of morphine. Discrimination learning was apparent at doses of 2.0, 1.5, 1.0, 0.75 and 0.5 mg/kg. Animals initially trained with 1.0 mg/kg morphine also learned the discrimination but required 10 training cycles. After this initial discrimination the subjects were trained with progressively lower dosages of morphine and showed a discrimination at a dosage of 0.5 mg/kg.     

Low-dimensional chaos maps learning in a model neuropil (olfactory bulb).

Quantification of a chaotic system can be made by calculating the correlation dimension (D2) of the data that the system generates (Packard et al., 1980). The D2 algorithm, however, requires stationarity of the generator, a feature that biological data rarely reflect (Mayer-Kress et al., 1988). So we developed the "point correlation dimension" (PD2), an algorithm that accurately tracks D2 in linked data of different dimensions (Carpeggiani et al., 1991). We now present a mathematical argument that, for stationary data, individual PD2s converge to D2 and we demonstrate that the algorithm rejects contributions made by bursts of noise. Data were obtained from the surface of the olfactory bulb of the conscious rabbit (64 electrodes, 640 Hz each, 1.3 sec epochs) before and after presentation of a novel or habituated odor. D2 could be calculated in only 1 of 10 novel-odor trials, whereas PD2 could be calculated in all. Both algorithms indicated that a novel odor evokes a spatially uniform dimensional increase. The PD2 uniquely exhibited the dimensional decreases that occur during inspiration and the gradients of mean dimension present during the nonstimulated control state. These control gradients remained unchanged without odor experience, but showed spatially specific PD2 increases following odor habituation. It is interpreted that, 1) the PD2 is sensitive, accurate, and appropriate for dimensional assessment of biological data, 2) that during analysis of unfamiliar information a single global process is transiently evoked in the neuropil, and 3) after experience multiple spatially specific processes tonically map the sites of learning.     

Brief report: An extension of the sequential alternating treatment design using reversals with subjects not available concurrently

This brief report proposes an extension of the traditional Alternating Treatments Design that would be acceptable to use in hospital and residential settings where subjects are often not concurrently available. Concerns about the inability of traditional designs to work in these special situations and the emergence of a “scientist–practitioner split” are discussed. An example of how the Extended Alternating Treatments Design might be used is provided.     

Application of chaos theory to biology and medicine

The application of “chaos theory” to the physical and chemical sciences has resolved some long-standing problems, such as how to calculate a turbulent event in fluid dynamics or how to quantify the pathway of a molecule during Brownian motion. Biology and medicine also have unresolved problems, such as how to predict the occurrence of lethal arrhythmias or epileptic seizures. The quantification of a chaotic system, such as the nervous system, can occur by calculating the correlation dimension (D2) of a sample of the data that the system generates. For biological systems, the point correlation dimension (PD2) has an advantage in that it does not presume stationarity of the data, as the D2 algorithm must, and thus can track the transient non-stationarities that occur when the systems changes state. Such non-stationarities arise during normal functioning (e.g., during an event-related potential) or in pathology (e.g., in epilepsy or cardiac arrhythmogenesis). When stochastic analyses, such as the standard deviation or power spectrum, are performed on the same data they often have a reduced sensitivity and specifity compared to the dimensional measures. For example, a reduced standard deviation of heartbeat intervals can predict increased mortality in a group of cardiac subjects, each of which has a reduced standard deviation, but it cannot specify which individuals will or will not manifest lethal arrhythmogenesis; in contrast, the PD2 of the very same data can specify which patients will manifest sudden death. The explanation for the greater sensitivity and specificity of the dimensional measures is that they aredeterministic, and thus are moreaccurate in quantifying the time-series. This accuracy appears to be significant in detecting pathology in biological systems, and thus the use of deterministic measures may lead to breakthroughs in the diagnosis and treatment of some medical disorders.     

Low-dimensional chaos maps learning in a model neuropil (olfactory bulb)

Quantification of a chaotic system can be made by calculating the correlation dimension (D2) of the data that the system generates (Packard et al., 1980). The D2 algorithm, however, requires stationarity of the generator, a feature that biological data rarely reflect (Mayer-Kress et al., 1988). So we developed the “point correlation dimension” (PD2), an algorithm that accurately tracks D2 in linked data of different dimensions (Carpeggiani et al., 1991). We now present a mathematical argument that, for stationary data, individual PD2s converge to D2 and we demonstrate that the algorithm rejects contributions made by bursts of noise. Data were obtained from the surface of the olfactory bulb of the conscious rabbit (64 electrodes, 640 Hz each, 1.3 sec epochs) before and after presentation of a novel or habituated odor. D2 could be calculated in only 1 of 10 novel-odor trials, whereas PD2 could be calculated in all. Both algorithms indicated that a novel odor evokes a spatially uniform dimensional increase. The PD2 uniquely exhibited the dimensional decreases that occur during inspiration and the gradients of mean dimension present during the nonstimulated control state. These control gradients remained unchanged without odor experience, but showed spatially specific PD2 increases following odor habituation. It is interpreted that, 1) the PD2 issensitive, accurate, and appropriate for dimensional assessment of biological data, 2) that during analysis of unfamiliar information a singleglobal process is transiently evoked in the neuropil, and 3) after experience multiplespatially specific processes tonically map the sites of learning. Grant Support: National Institutes of Health, HL 31164 and NS27745     

The applicability of verbal mnemonics for different populations: A review

The main aims of this review were to assess(1) the likelihood of learners making spontaneous use of verbal mnemonics, and (2) the extent to which learners will benefit from using verbal mnemonics. Over 60 investigations of verbal mnemonics were reviewed, most of which concentrated upon sentence mnemonics or first-letter mnemonics; although many of the studies used students as subjects, the review also considers the value of verbal mnemonics for schoolchildren, mentally handicapped people, brain-injured patients, and the elderly. On the whole, verbal mnemonics are relatively popular internal memory aids and, when compared to standard control conditions such as rehearsal, appear to be effective learning strategies for most of the populations studied, although mentally handicapped people and schoolchildren may find it difficult to produce effective mnemonics themselves; additionally, students and schoolchildren can benefit from the use of mnemonic sentences as part of more complex techniques. Comparisons between verbal mnemonics and other memory-aiding strategies have, however, given more equivocal results. A number of areas for future research are identified. In particular it is hoped to see a development of recent trends to use non-student subject, and to investigate the applicability of verbal mnemonics outside the laboratory.     

Counselling issues in the fostering and adoption of children at risk of HIV infection

The heterosexual nature of the HIV epidemic in Lothian is such that a number (50 to date) of babies have been born to women who have HIV. Some have needed social work services such as Children Centre placement, foster parents or adopters. Since this work began in 1986, our understanding of the transmission and manifestation of HIV infection in children has grown. However, it is still not possible until children reach the age of two to be certain whether or not they have been infected, or what the outlook is for them. Even then there are some further areas of uncertainty. We have developed a programme of preparation, training and support which has enabled a number of families to live with this uncertainly in offering placements to children at risk of HIV infection.