触觉空间精确性与触觉神经元密度相关联的验证

本研究应用栅栏定向任务,通过对小学一年级儿童和大学生的触觉敏感性的比较,验证触觉敏感性与神经元密度的关系。结果表明：对较大的易于分辨的刺激,成人可以完成得较好,而对较细小的难于分辨的刺激,儿童成绩更好。本研究验证了高感受单元密度对应较强的触觉敏感性的假设。     

词切分对语文学优生与学困生阅读影响的眼动研究

采用EyeLink II眼动仪,以小学二年级语文学优生和学困生为被试,考察词切分对句子阅读的影响.实验设置四种空格呈现条件:正常无空格条件、字间空格条件、词间空格条件和非词空格条件.研究表明:(1)小学二年级学生阅读词间空格文本、字间空格文本和正常无空格文本效果相同.(2)与语文学优生相比,学困生阅读任何条件的句子需要更多的注视时间和注视次数.非词空格呈现条件对学困生的干扰更大,表明学困生更依赖文本的低水平信息.文章最后探讨了汉语阅读的基本信息单元问题.     

儒学"意"范畴与阳明学的"主意"话语

儒家的"意"范畴及宋明以后出现的"主意"学说,与道家所言之"意"干系甚微.对"主意"学说的形成、发展有直接影响的是儒、佛两家对"意"之范畴的诠释与阐述.儒学的"意"范畴,既可从"毋意"说出发而作私意、意念之理解,又可从"诚意"说出发而作意向、志意之解读;既可基于工夫论而把"诚意"视为"欲诚之意",又可基于本体论而把"诚意"视为"已诚之意";既可使"意"与"志"相结合,又可使"意"与"念"相并列.明中叶后"主意"一词由工夫层面的"诚意"范畴提升为本体层面的"意根"范畴,这种转变,既有历史逻辑的承继关系,又有阳明心学之修正思潮的现实推动.     

Mothers' affect in the homework context: the importance of staying positive

This research investigated mothers' affect in the context of children's homework. Mothers (N = 109) of children 8 to 12 years old were interviewed daily about their affect while interacting with children, their assistance with children's homework, and children's behavior while completing homework. At this time and 6 months later, children's motivational and emotional functioning was assessed. Although mothers' negative affect was lower than their positive affect, it was elevated on days their assistance with homework was high. This was accounted for by mothers' perceptions of children as helpless on days they provided heightened assistance. Mothers' positive affect in the homework context buffered children's motivational and emotional functioning against mothers' negative affect as well as children's helplessness.     

科学、理性：看奥巴马新政

奥巴马在科学问题和理性态度方面的言行深受美国科学家欢迎。本文综述了奥巴马在科学问题的言论和具体的内阁任命时尊重科学家的行为,特别是对智能设计论的否定态度：介绍了美国科学界对奥巴马的评价和对奥巴马执政的期盼,值得中国读者关注。     

Stress induces glucocorticoid-mediated apoptosis of rat Leydig cells in vivo

Stress can disrupt endocrine signalling in the male reproductive axis through high concentrations of glucocorticoids, the hallmark of stress. Our previous work revealed that a stress level of exogenous glucocorticoids could induce apoptosis of rat Leydig cells, which are the primary source of testosterone. The aim of this study was to investigate whether stress can induce apoptosis in rat Leydig cells in vivo and, if so, whether the process is the result of a direct effect of glucocorticoids. In a chronically stressed rat model, serum corticosterone concentration was increased significantly whereas serum testosterone was decreased. The frequency of apoptotic Leydig cells in stressed rats was also increased. Adrenalectomised rats subjected to chronic stress showed an elevated serum testosterone, while the apoptotic frequency of Leydig cells was not increased. It was established that glucocorticoid-induced Leydig cell apoptosis is mediated by glucocorticoid receptors (GRs), which translocate from cytoplasm to nucleus. Adenovirus microRNA-induced downregulation of GR expression in vitro alleviated the corticosterone-induced increase in apoptosis of Leydig cells. These results indicate that the stress-induced increase in corticosterone secretion resulted in apoptosis in rat Leydig cells in vivo, and thereby decreased testosterone synthesis.     

Effects of telephone support on exercise capacity and quality of life in patients with chronic obstructive pulmonary disease: a meta-analysis

The aim of this meta-analysis was to evaluate the effects of disease education or pulmonary rehabilitation programs assisted with telephone support on physical capacity and quality of life (QOL) in chronic obstructive pulmonary disease (COPD) patients. A systematic search of PubMed, Embase, Web of Science and The Cochrane Library was conducted until May 2017. Randomized controlled trials (RCTs) examining the effects of telephone-assisted intervention versus a control group on exercise tolerance and QOL in patients with COPD were included. Two independent authors assessed the methodological quality of the trials using the Cochrane risk of bias tool. A meta-analysis was conducted with the Revman5.3 to quantify the effects of telephone-assisted interventions on walking capacity and QOL. In total, 10 studies involving 1037 participants were included. Due to the effect of telephone-assisted interventions, statistically significant results were found on Saint-George’s Respiratory Questionnaire (SGRQ) symptom scores [standard mean difference (SMD) ?.18, 95% confidence interval (CI) ?.33, ?.03, p-value .02)], SGRQ impact scores [SMD ?.35, 95% CI ?.60, ?.10, p-value .006)], SGRQ activity scores [SMD ?.30, 95% CI ?.45, ?.15, p-value < .0001)], SGRQ total score [SMD ?.36, 95% CI ?.51, ?.21, p-value < .00001)]. The effects on 6-min walk test (6MWT) and all Chronic Respiratory Questionnaire (CRQ) subscales were not significant (p > .05) based on the insufficient evidence. In conclusion, the role of telephone-assisted interventions in the management of COPD remains equivocal. Some encouraging results were seen with regard to SGRQ symptom, SGRQ impact, SGRQ activity and SGRQ total score. We believe that more methodologically rigorous large-scale randomized controlled trials are necessary to answer this study question.