Cognitive deficits in relation to personality type and hypothalamic-pituitary-adrenal (HPA) axis dysfunction in women with stress-related exhaustion

Exhaustion caused by long-term work-related stress may cause cognitive dysfunction. We explored factors that may link chronic stress and cognitive impairment. Personality, psychiatric screening, and behavior were assessed by self-reporting measures in 20 female patients (mean age 39.3 years; range 26-53) with a preliminary diagnosis of stress-related exhaustion and in 16 healthy matched controls. Cognitive performance was investigated with a detailed neuropsychological test battery. Cortisol axis function was assessed by urinary and saliva collections of cortisol, dexamethasone suppression, Synacthen response, and corticotropin-releasing hormone (CRH) tests. Proinflammatory cytokines were measured. Hippocampal volumes were estimated by magnetic resonance imaging. Multivariate and univariate statistical methods were used to explore putative differences between groups and factors linked to cognitive impairment. Cognitive function clearly differed between groups, with decreased attention and visuospatial memory in the patient group, suggesting frontal cortex/medial temporal cortex-network dysfunction. Increased harm avoidance and persistence was present among patients, with lowered self-directedness linked to lower quality of life, increased anxious and depressive tendencies, and experiences of psychosocial stress. Attention was decreased with concomitantly impaired visuospatial memory. The pituitary (adrenocorticotropic hormone, ACTH) response to CRH was decreased in patients, with an increased cortisol/ACTH response to CRH. However, cortisol production rates, diurnal or dexamethasone-suppressed saliva cortisol levels, and the cortisol response to Synacthen were unaltered. Hippocampal volumes did not differ between groups. These findings suggest that cognitive dysfunction in stress-related exhaustion is linked to distinct personality traits, low quality of life, and a decreased ACTH response to CRH.     

Low social inclusion in childhood: adjustment and early predictors

The principal aim of the present study was to obtain a deeper understanding than hitherto of the concurrent correlates and prospective predictors of loneliness and poor peer acceptance, both falling under the umbrella term low social inclusion. Problematic and socially competent behaviours were investigated as possible predictors of low social inclusion in grade 6, as defined by self‐rated loneliness and degree of peer non‐acceptance, respectively. In grade 6 808 children participated whereof 323 were followed longitudinally from first grade. Loneliness in grade 6 was distinctively associated with high levels of internalizing problems, concurrently as well as prospectively. Peer acceptance, on the other hand, emerged as a complex, multifaceted aspect, with concurrent, independent predictions from both externalizing and internalizing problem behaviours as well as social competence, although prospective analyses found early externalizing problems to be the strongest predictor of peer acceptance. Moderating effects of social competence were sparse, although peer nominated social competence buffered peer acceptance for children with high levels of aggression in the concurrent analyses and social competence boosted peer acceptance for children with low problem levels in the predictive analyses. Social competence did not appear to buffer the negative impact of early problem behaviours on peer relations. Copyright © 2008 John Wiley & Sons, Ltd.     

How well do measures of inhibition and other executive functions discriminate between children with ADHD and controls?

The aim of the present study was to evaluate the usefulness of Barkley's (1997a) model of inhibition and executive functioning in describing the deficits associated with Attention Deficit Hyperactivity Disorder (ADHD). Besides group differences, the present study addressed the question of independent effects of inhibition and the other executive functions in discriminating between children with ADHD and controls and how well, in terms of sensitivity and specificity, these measures can classify the children into the correct group. The results showed that children with ADHD differed significantly from controls with regard to measures of inhibition as well as all other executive function measures, except repetition of hand movements. In logistic regression models, three different measures tapping inhibition, working memory and emotion regulation were shown to be significant independent predictors of group membership. The sensitivity for these three variables as a set was 76.2, the specificity was 90.5, with a total of 86% of the sample correctly classified. When excluding the parental rating of emotion regulation, the overall classification rate decreased some, but was still relatively high in comparison with previous studies within this area of research.     

Incidental retrieval processes influence explicit test performance with data-limited cues

In two experiments, the influence of incidental retrieval processes on explicit test performance was tested. In Experiment 1, subjects studied words under four conditions (auditory-shallow, auditory-deep, visual-shallow, and visual-deep). One group of subjects received auditory and visual word-fragment completion; another group received auditory and visual word-fragment cued recall. Results indicated that changes in sensory modality between study and test reduced both recall and priming performances; levels of processing significantly affected only the cued recall test. These results indicated that incidental retrieval processes might affect explicit test performance when retrieval cues are data limited. Experiment 2 supported this conclusion by showing an effect of matching study and test modalities on explicit test performance with fragment but not with copy cues. Taken together, these results support Roediger and McDermott’s (1993) suggestion that explicit test performance is influenced by incidental retrieval processes when data-limited retrieval cues are used.     

A component analysis of action events

Summary Three experiments are reported, that examine the basis of the recall superiority of subject-performed tasks (SPTs) over verbal-memory tasks (VTs), and the interitem variability for SPTs. In Experiments 1 and 2 a component analysis of SPTs is undertaken in order to explore the importance of (a) involvement of external objects, (b) multimodality, and (c) enactment, for the superior memory performance for SPTs over that for VTs. In Experiment 3 the role of retrieval support, in terms of a high degree of match between the encoding and retrieval situations, was investigated in order to find out why some SPTs are easier to recall than others. The results indicate that it is difficult to separate out a single component as the most critical one for the superiority of SPT recall over VT recall, and that a high degree of match between encoding and retrieval conditions improves SPT recall. It is suggested that, in order to explain the large differences in memorability between SPTs and VTs, it is sufficient to consider the more supportive encoding situation for SPTs, but to explain differences in recallability between various SPTs, the compatibility between encoding and test has to be taken into consideration.     

Disorganized Attachment and Inhibitory Capacity: Predicting Externalizing Problem Behaviors

The aim of the present study was to investigate whether attachment insecurity, focusing on disorganized attachment, and the executive function (EF) component of inhibition, assessed at age 5, were longitudinally related to general externalizing problem behaviors as well as to specific symptoms of ADHD and Autism spectrum disorder (ASD), and callous-unemotional (CU) traits. General externalizing problem behaviors were also measured at age 5 to allow for a developmental analysis. Outcome variables were rated by parents and teachers. The sample consisted of 65 children with an oversampling of children with high levels of externalizing behaviors. Attachment was evaluated using a story stem attachment doll play procedure. Inhibition was measured using four different tasks. The results showed that both disorganized attachment and poor inhibition were longitudinally related to all outcome variables. Controlling for initial level of externalizing problem behavior, poor inhibition predicted ADHD symptoms and externalizing problem behaviors, independent of disorganized attachment, whereas for ASD symptoms no predictive relations remained. Disorganized attachment independently predicted CU traits.     

Memory aging and brain maintenance

Episodic memory and working memory decline with advancing age. Nevertheless, large-scale population-based studies document well-preserved memory functioning in some older individuals. The influential ‘reserve’ notion holds that individual differences in brain characteristics or in the manner people process tasks allow some individuals to cope better than others with brain pathology and hence show preserved memory performance. Here, we discuss a complementary concept, that of brain maintenance (or relative lack of brain pathology), and argue that it constitutes the primary determinant of successful memory aging. We discuss evidence for brain maintenance at different levels: cellular, neurochemical, gray- and white-matter integrity, and systems-level activation patterns. Various genetic and lifestyle factors support brain maintenance in aging and interventions may be designed to promote maintenance of brain structure and function in late life.     

Neuropsicología cognitiva: Consideraciones metodológicas

Resumen

El presente trabajo es teórico y pretende ofrecer una revisión metodológica en una rama de la psicología que está en pleno auge, la neuropsicología cognitiva. El trabajo consta de los siguientes puntos: definición de la neuropsicología cognitiva y delimitación del concepto frente a la neuropsicología tradicional; relaciones entre la neuropsicología y la psicología cognitivas; métodos actuales en neuropsicología cognitiva, esto es, descripción y consideraciones de las distintas aproximaciones metodológicas; razones para el estudio de caso único, el método de la coherencia con el paciente, el método de la disociación en base a la hipótesis de la modularidad, el método de las constelaciones de síntomas y, por último, los requisitos necesarios para el sistemático estudio de caso único; críticas y conclusiones.     

Dependencia-Independencia de Campo y Diferenciación Hemisférica en tareas de escucha dicótica

Resumen

En una muestra de 60 estudiantes voluntarios, se ha examinado la relación existente entre el estilo perceptivo «dependencia-independencia de campo» medido a través del R FT, EFT y GEFT y el grado de diferenciación hemisférica auditiva operativizado mediante dos tareas de escucha dicótica, una verbal y otra musical. Los resultados revelan un procesamiento claramente lateralizado en los sujetos independientes de campo frente a una bilateralización en los dependientes de campo.