Fibromyalgia: the role of sleep in affect and in negative event reactivity and recovery

OBJECTIVE: Fibromyalgia (FM) syndrome is a chronic pain condition characterized by diffuse muscle pain, increased negative mood, and sleep disturbance. Until recently, sleep disturbance in persons with FM has been modeled as the result of the disease process or its associated pain. The current study examined sleep disturbance (i.e., sleep duration and sleep quality) as a predictor of daily affect, stress reactivity, and stress recovery. DESIGN AND MEASURES: A hybrid of daily diary and ecological momentary assessment methodology was used to evaluate the psychosocial functioning of 89 women with FM. Participants recorded numeric ratings of pain, fatigue, and positive and negative affect 3 times throughout the day for 30 consecutive days. At the end of each day, participants completed daily diary records of positive and negative life events. In addition, participants reported on their sleep duration and sleep quality each morning. RESULTS: After accounting for the effects of positive events, negative events, and pain on daily affect scores, it was found that sleep duration and quality were prospectively related to affect and fatigue. Furthermore, the effects of inadequate sleep on negative affect were cumulative. In addition, an inadequate amount of sleep prevented affective recovery from days with a high number of negative events. CONCLUSIONS: These results lend support to the hypothesis that sleep is a component of allostatic load and has an upstream role in daily functioning.     

The priority of primary process categorizing: experimental evidence supporting a psychoanalytic developmental hypothesis

Earlier work has provided experimental evidence for the existence of the primary and secondary process mental organization posited by Freud and has demonstrated that primary process effects are the more active unconsciously (Brakel et al. 2000). Primary and secondary processes were assessed by a categorization test in which qualitatively different principles could be used. In new experiments using the same stimuli, another significant implication of Freud's model was tested: that primary process mental organization has developmental priority. In these experiments, which studied 559 participants ranging in age from 3 to 80, it was found (1) that primary process mentation predominates in preschoolers; (2) that it is not until around age 7 that primary process organization is supplanted by secondary process organization; and (3) that after age 7 the predominance of secondary process organization remains remarkably stable throughout the life span.     

The natural history of gambling and drinking problems among casino employees

From an eligible population of 9,943 casino employees, 6,067 volunteered to participate in this study. Of this sample, 1,176 provided data at 3 observation points approximately 12 months apart. Using the South Oaks Gambling Screen (SOGS; H. R. Lesieur & S. B. Blume, 1987) and the CAGE (J. A. Ewing, 1984) questionnaire, the authors prospectively examined the prevalence and patterns of alcohol and gambling problems among those employees. Among the casino employees with gambling and drinking problems, a segment displayed the capacity to diminish those problems even when the difficulties had reached disordered levels. The authors also examined the comorbidity of gambling and drinking as well as the relationships among changes in SOGS scores and CAGE scores and changes in demographic and biological variables. The women were more likely to decrease their problem-drinking scores, but not their gambling scores, when compared with the men. In addition, 2 key variables (i.e., disabling depression and dissatisfaction with one's personal life) emerged as predictors of transitions to healthier levels of disordered gambling. The authors cautiously suggest, in light of the results taken together, that more fluctuation is associated with gambling and drinking problems than previously thought and that the conventional wisdom about disordered gambling as "always progressive" needs reconsideration.     

Dissociation of explicit and implicit timing in repetitive tapping and drawing movements

Four experiments explored the hypothesis that temporal processes may be represented and controlled explicitly or implicitly. Tasks hypothesized to require explicit timing were duration discrimination, tapping, and intermittent circle drawing. In contrast, it was hypothesized that timing control during continuous circle drawing does not rely on an explicit temporal representation; rather, temporal control is an emergent property of other control processes (i.e., timing is controlled implicitly). Temporal consistency on the tapping and intermittent drawing tasks was related, and performance on both of these tasks was correlated with temporal acuity on an auditory duration discrimination task. However, timing variability of these 3 tasks was not correlated with timing variability of continuous circle drawing. These results support the hypothesized distinction between explicit and implicit temporal representations.     

The Fisher-Pitman permutation test: an attractive alternative to the F test

The Fisher-Pitman permutation test is shown to possess significant advantages over conventional alternatives when analyzing differences among independent samples with unequal variances.     

Age dissociates recency and lag recency effects in free recall

The temporal relations among word-list items exert a powerful influence on episodic memory retrieval. Two experiments were conducted with younger and older adults in which the age-related recall deficit was examined by using a decomposition method to the serial position curve, partitioning performance into (a) the probability of first recall, illustrating the recency effect, and (b) the conditional response probability, illustrating the lag recency effect (M. W. Howard & M. J. Kahana, 1999). Although the older adults initiated recall in the same manner in both immediate and delayed free recall, temporal proximity of study items (contiguity) exerted a much weaker influence on recall transitions in older adults. This finding suggests that an associative deficit may be an important contributor to older adults' well-known impairment in free recall.     

Pharmacogenetics: ethical issues and policy options

Pharmacogenetics offers the prospect of an era of safer and more effective drugs, as well as more individualized use of drug therapies. Before the benefits of pharmacogenetics can be realized, the ethical issues that arise in research and clinical application of pharmacogenetic technologies must be addressed. The ethical issues raised by pharmacogenetics can be addressed under six headings: (1) regulatory oversight, (2) confidentiality and privacy, (3) informed consent, (4) availability of drugs, (5) access, and (6) clinicians' changing responsibilities in the era of pharmacogenetic medicine. We analyze each of these categories of ethical issues and provide policy approaches for addressing them.     

A neural correlate of consciousness related to repression

In previous research Libet (1966) discovered that a critical time period for neural activation is necessary in order for a stimulus to become conscious. This necessary time period varies from subject to subject. In this current study, six subjects for whom the time for neural activation of consciousness had been previously determined were administered a battery of psychological tests on the basis of which ratings were made of degree of repressiveness. As hypothesized, repressive subjects had a longer critical time period for neural activation of consciousness, suggesting the possibility that this neurophysiological time factor is a necessary condition for the development of repression.