Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ 1-42 oligomer injection

Soluble oligomeric forms of amyloid beta (AβO) are regarded as a main cause of synaptic and cognitive dysfunction in Alzheimer’s disease (AD) and have been a primary target in the development of drug treatments for AD. The present study utilized a mouse model of AD induced by intrahippocampal injection of AβO (10 μM) to investigate the effects of Gami-Chunghyuldan (GCD), a standardized multi-herbal medicinal formula, on the presentation of memory deficits and neurohistological pathogenesis. GCD (10 and 50 mg/kg/day, 5 days, p.o.) improved AβO-induced memory impairment as well as reduced neuronal cell death, astrogliosis, and microgliosis in the hippocampus. In addition, GCD prevented AβO-triggered synaptic disruption and cholinergic fiber loss. These results suggest that GCD may be useful in the prevention and treatment of AD.     

Prism adaptation in schizophrenia

The prism adaptation test examines procedural learning (PL) in which performance facilitation occurs with practice on tasks without the need for conscious awareness. Dynamic interactions between frontostriatal cortices, basal ganglia, and the cerebellum have been shown to play key roles in PL. Disruptions within these neural networks have also been implicated in schizophrenia, and such disruptions may manifest as impairment in prism adaptation test performance in schizophrenia patients. This study examined prism adaptation in a sample of patients diagnosed with schizophrenia (N=91) and healthy normal controls (N=58). Quantitative indices of performance during prism adaptation conditions with and without visual feedback were studied. Schizophrenia patients were significantly more impaired in adapting to prism distortion and demonstrated poorer quality of PL. Patients did not differ from healthy controls on aftereffects when the prisms were removed, but they had significantly greater difficulties in reorientation. Deficits in prism adaptation among schizophrenia patients may be due to abnormalities in motor programming arising from the disruptions within the neural networks that subserve PL.     

Fragile X mental retardation protein levels increase following complex environment exposure in rat brain regions undergoing active synaptogenesis

Fragile X mental retardation protein (FMRP), which is absent in fragile X syndrome, is synthesized in vitro in response to neurotransmitter activation. Humans and mice lacking FMRP exhibit abnormal dendritic spine development, suggesting that this protein plays an important role in synaptic plasticity. Previously, our laboratory demonstrated increased FMRP immunoreactivity in visual cortex of rats exposed to complex environments (EC) and in motor cortex of rats trained on motor-skill tasks compared with animals reared individually in standard laboratory housing (IC). Here, we use immunohistochemistry to extend those findings by investigating FMRP levels in visual cortex and hippocampal dentate gyrus of animals exposed to EC or IC. Rats exposed to EC for 20 days exhibited increased FMRP immunoreactivity in visual cortex compared with animals housed in standard laboratory caging. In the dentate gyrus, animals exposed to EC for 20 days had higher FMRP levels than animals exposed to EC for 5 or 10 days. In light of possible antibody crossreactivity with closely related proteins FXR1P and FXR2P, FMRP immunoreactivity in the posterior-dorsal one-third of cerebral cortex was also examined by Western blotting following 20 days of EC exposure. FMRP levels were greater in EC animals, whereas levels of FXR1P and FXR2P were unaffected by experience. These results provide further evidence for behaviorally induced alteration of FMRP expression in contrast to its homologues, extend previous findings suggesting regulation of its expression by synaptic activity, and support the theories associating FMRP expression with alteration of synaptic structure both in development and later in the life-cycle.     

In search of the good life: a cultural odyssey in the East and West

In the first part of this article, the authors argue that any conception of well-being is culturally embedded and depends on how the notions of "well" and "being" are defined and practiced in different cultural communities. To support this argument, they conduct a comprehensive review of the empirical literature, which shows that members of individualistic and collectivistic cultures differ in their emotional experience of well-being. This difference has been traced to the indigenous psychology of selfhood in those cultures. In the second part of the article, the authors debunk the myth of infinite cultural variability, while retaining the basic insight concerning the cultural constitution of well-being. They develop a theoretical model of well-being, in which agency and communion are universal dimensions of well-being, and people in different cultures require different combinations of agency and communion to experience well-being. Following this theoretical development, the authors examine cultural impediments to the good life in individualistic and collectivistic cultures. The mutual incompatibility of agency and communion is ruled out as a possible cause of why it is so difficult to live the good life. Instead, the authors propose a dialectical synthesis of agency and communion as a way of dealing with this challenge of living the good life.     

Great Expectations: The Negative Consequences of Falling Short1

The present study shows conditions under which a positive stereotypic belief–Asians are good in mathematics–can have negative consequences. Participants graded a poorly performed mathematical assignment that they believed was the work of an Asian or a White target person. Under no accuracy instructions, participants who spent less time grading (unmotivated participants) assigned fewer points to the Asian than the White target. There was no difference in assignment of points to the Asian or the White target when participants were given accuracy instructions or spent more time grading (motivated participants). The findings suggest that group members may experience negative consequences when they fall short of “great expectations” stemming from a positive stereotypic belief about their group.     

“Celebrities to lean on!” Perceived celebrity support across two cultures—Iran and the United States

Though many people loathe celebrities and their lifestyles, celebrities can also be perceived as being available to provide community support. The purpose of this study was to establish the psychometric properties of the Perceived Celebrity Support Inventory. The scale was developed to capture three aspects of perceived celebrity support to the community: instrumental (i.e., providing tangible and concrete assistance), informational (i.e., advice, explanation, and information), and emotional (i.e., empathizing, encouraging, listening, and comforting) support. Factor and item analyses have revealed robust psychometric properties in samples drawn from the United States (US) and Iran. The US sample perceived higher community support from celebrities than the Iranian sample. In the Iranian sample, perceived celebrity support for the community was associated with more positive attitudes and less hatred of celebrity culture. In the US, perceived celebrity support was associated with negative attitudes and elevated hatred towards celebrities. The findings advance the literature by providing an instrument with which to measure positive aspects of celebrity influence across cultures.     

Discovery of the pendulum and spring dynamics in the early stages of walking

The authors investigated the self-selected, overground walking patterns of 7 children (aged 11 months to 1 year, 5 months) at the initiation of walking (brand-new walkers [BNWs]) and for the next 6 months at 1-month intervals. Walking speed, stride length, and stride frequency increased significantly between the first 2 visits without significant changes in height and weight. The authors calculated sagittal plane angular accelerations of the center of mass over the foot for each step as an indicator of the escapement pulse. Results for the acceleration profiles changed after the 1st visit to positive, single-peaked accelerations that occurred < 0.20 s after initial foot contact. Increases in sagittal plane hip angular displacement and decreases in frontal plane pelvic angular displacement were observed. The pattern changes suggest that children quickly discover appropriately timed and directed escapements that initiate and support the conservative sagittal plane pendulum and spring dynamics observed in older children.