Effect of catatoxic steroids upon lidocaine intoxication

Various steroids have been shown to influence the activity of psychotropic hormones and drugs. Among these, we distinguish “syntoxic” steroids which act by inhibiting excessive reactions to various agents and “catatoxic” steroids which actually destroy certain toxicants and hormones often through the induction of hepatic microsomal enzymes. Thus, the liver can play a decisive role in psychosomatic interrelations by regulating the blood clearance of agents affecting the nervous system. To illustrate these principles, new observations are presented which show that certain catatoxic steroids offer considerable protection against lidocaine, an anesthetic, analgesic drug. These findings may serve as an example showing how modern research techniques may help us to analyze the possible relationships between the liver and the mind, which were intuitively suspected since Hippocrates created the term “melancholia.”     

Data on the role of the frontal cortex in vegetative behavior

A homeostatic conditional reflex (CR) was elaborated to the effect of repeated inhalations in rats of a gas mixture containing 8 per cent oxygen. The effect of the conditional response was opposite to that of the unconditional one. After ablation of the frontal cortex, the conditional reaction disappeared. The repeated administration of 40 mg/kg of histamine resulted in a tolerance to the temperature lowering effect of histamine similar to the habituation. An injection of distilled water brought about dishabituation. Tolerance was not influenced by the ablation of the frontal cortex, but the dishabituating effect of distilled water was absent.     

The legacy of Hans Selye and the origins of stress research: A retrospective 75 years after his landmark brief "Letter" to the Editor(#) of Nature

Hans Selye's single author short letter to Nature (1936, 138(3479):32) inspired a huge and still growing wave of medical research. His experiments with rats led to recognition of the "general adaptation syndrome", later renamed by Selye "stress response": the triad of enlarged adrenal glands, lymph node and thymic atrophy, and gastric erosions/ulcers. Because of the major role of glucocorticoids (named by Selye), he performed extensive structure-activity studies in the 1930s-1940s, resulting in the first rational classification of steroid hormones, e.g. corticoids, testoids/androgens, and folliculoids/estrogens. During those years, he recognized the respective anti- and pro-inflammatory actions of gluco- and mineralocorticoids in animal models, several years before demonstration of anti-rheumatic actions of cortisone and adrenocorticotrophic hormones in patients. Nevertheless, Selye did not receive a Nobel Prize, which was awarded in 1950 to the clinician Hench and the two chemists who isolated and synthesized some of the glucocorticoids. Nonetheless, Selye was internationally recognized as a world authority in endocrinology, steroid chemistry, experimental surgery, and pathology. He wrote over 1500 original and review articles, singly authored 32 books, and trained 40 PhD students, one of whom (Roger Guillemin) won a Nobel Prize for isolating the hypothalamic releasing factors/hormones. Here, we consider the main implications of his first article launching the biological stress concept and the key ideas and problems that occupied him. Selye considered "Stress in heath and disease is medically, sociologically, and philosophically the most meaningful subject for humanity that I can think of".     

Interference resolution in retrieval-induced forgetting: Behavioral evidence for a nonmonotonic relationship between interference and forgetting

Retrieving memories renders related memories less accessible. This phenomenon, termed retrieval-induced forgetting (RIF), is thought to be the result of processes that resolve interference during competitive retrieval. In several studies, researchers have manipulated the level of interference to test different theoretical accounts of RIF (e.g., inhibitory vs. noninhibitory). However, the nature of how interference and RIF are related has not been systematically investigated. Here, we introduce a design that allows for assessing interference during competitive retrieval by measuring the recall RTs associated with target recall. Using such a design, we found that RIF occurred only when interference during competitive retrieval reached moderate levels, but not when it was too low or too high. This finding might indicate that low levels of interference do not trigger interference resolution, whereas interference resolution might fail when the interference reaches extremely high levels.     

On the Fundamental Worldview of the Integral Culture: Integrating Science,Religion, and Art: Part One

In the present essay the author suggests that the main reason why history failed to develop societies in harmony with Nature, including our internal nature as well, is that we failed to evaluate the exact basis of the factor ultimately governing our thoughts. We failed to realize that it is the worldview that ultimately governs our thoughts and through our thoughts, our actions. In this work we consider the ultimate foundations of philosophy, science, religion, and art, pointing out that they were and can be again in harmony with each other if their ultimate tasks are specified. It is specified here the first task of philosophy as considering the philosophical significance of the ultimate principles of physics, biology and man/society. These ultimate principles are in direct connection with the ultimate questions of religion. It is shown that the fundamental nature of art makes it able to perceive the ultimate destination of mankind and the Universe, the world-to-be. It is proposed that philosophy, religion and art together are able to supply us with an inter-subjective picture of the world-process, including the inter-subjective picture of the future of mankind and the Universe. Care is taken to enlighten the possible role of values in founding scientific research in the frame of present wide-ranging discussions. It is found that universal values of respect for existence, life and reason represent the inevitable basis of science. The exact foundations of a new, integral worldview are outlined, involving the worldprocess-picture, Nature-picture, images of man, society, self, history and manipulation. A list of our common tasks for founding the Integral Culture is proposed.     

The interplay of trait worry and trait anxiety in determining episodic retrieval: The role of cognitive control

Worrying is a key concept in describing the complex relationship between anxiety and cognitive control. On the one hand, cognitive control processes might underlie the specific tendency to engage in worrying (i.e., trait worry), conceptualized as a future-oriented mental problem-solving activity. On the other hand, the general tendency to experience the signs and symptoms of anxiety (i.e., trait anxiety) is suggested to impair cognitive control because worrisome thoughts interfere with task-relevant processing. Based on these opposing tendencies, we predicted that the effect of the two related constructs, trait anxiety and trait worry, might cancel out one another. In statistics, such instances have been termed suppressor situations. In four experiments, we found evidence for such a suppressor situation: When their shared variance was controlled, trait worry was positively whereas trait anxiety was negatively related to performance in a memory task requiring strategic, effortful retrieval. We also showed that these opposing effects are related to temporal context reinstatement. Our results suggest that trait worry and trait anxiety possess unique sources of variance, which differently relate to performance in memory tasks requiring cognitive control.     

Sobel on Pleasure,Reason, and Desire

The paper begins with a well-known objection to the idea that reasons for action are provided by desires. The objection holds that since desires are based on reasons (first premise), which they transmit but to which they cannot add (second premise), they cannot themselves provide reasons for action. In the paper I investigate an attack that has recently been launched against the first premise of the argument by David Sobel. Sobel invokes a counterexample: hedonic desires, i.e. the likings and dislikings of our present conscious states. The aim of the paper is to defend the premise by bringing the alleged counterexample under its scope. I first point out that reference to hedonic desires as a counterexample presupposes a particular understanding of pleasure, which we might call desire-based. In response, following Sobel, I draw up two alternative accounts, the phenomenological and the tracking views of pleasure. Although Sobel raises several objections to both accounts, I argue in detail that the phenomenological view is not as implausible as he claims it to be, whereas the tracking view, on its best version advocated by Thomas Scanlon, is an instance of the phenomenological view and is therefore also defensible.