创伤后应激障碍病因及发病机制的研究进展

创伤后应激障碍(post-traumatic stress disorder,PTSD)是一种严重的应激相关障碍,指个体面临异常强烈的精神应激后延迟发生的精神障碍,文献报告PTSD的终生患病率为1%～14%,高危人群研究发现PTSD的患病率为3%～58%,女性约为男性的两倍[1].PTSD的病因及发病机制较为复杂,涉及很多方面,本文将对PTSD病因及发病机制的研究进展进行综述.     

创伤后应激障碍患者的正念疗法

本文回顾了正念干预在创伤后应激障碍(PTSD)领域的应用进展,分析了正念疗法的核心内容、作用机制,创伤后应激障碍患者正念干预具体实施过程及身心干预效果。分析表明,作为辅助药物治疗方式可降低创伤后应激障碍患者创伤后应激症状阳性率,调节皮质醇水平,缓解疼痛与疲乏症状,改善认知功能障碍、心理健康及情绪调节,以提高PTSD患者正念水平及生存质量,目前对于单纯用药疗效差的PTSD患者,正念疗法作为辅助治疗手段来解决其PTSD是非常有益的尝试。     

失独父母创伤后应激障碍症状的潜在类别及其相关因素

摘 要 研究旨在探讨失独父母创伤后应激障碍（PTSD）症状的潜在类别及相关因素,分析不同类别失独父母心理韧性的差异。采用创伤后应激障碍量表（PCL-5）、心理韧性量表对385名失独父母进行测查。结果发现：（1）失独父母PTSD症状存在三种潜在类别：PTSD高症状组（30%）、PTSD中度症状组（38%）、PTSD低症状组（32%）。（2）相比PTSD低症状组而言,PTSD高或中度症状组有显著的年龄和失独年限效应,PTSD高症状组中年龄≤60岁、失独年限<10年的人群所占比例较高;PTSD中度症状组的年龄≤60岁的人群所占比例更高。（3）PTSD高症状组心理韧性得分显著低于其他两组。应及时关注和干预小于60岁、失独年限<10年和低心理韧性的失独群体。     

失独父母创伤后应激障碍症状的潜在类别及其相关因素

摘 要 研究旨在探讨失独父母创伤后应激障碍（PTSD）症状的潜在类别及相关因素,分析不同类别失独父母心理韧性的差异。采用创伤后应激障碍量表（PCL-5）、心理韧性量表对385名失独父母进行测查。结果发现：（1）失独父母PTSD症状存在三种潜在类别：PTSD高症状组（30%）、PTSD中度症状组（38%）、PTSD低症状组（32%）。（2）相比PTSD低症状组而言,PTSD高或中度症状组有显著的年龄和失独年限效应,PTSD高症状组中年龄≤60岁、失独年限<10年的人群所占比例较高;PTSD中度症状组的年龄≤60岁的人群所占比例更高。（3）PTSD高症状组心理韧性得分显著低于其他两组。应及时关注和干预小于60岁、失独年限<10年和低心理韧性的失独群体。     

汶川地震5年半后幸存者的创伤后应激障碍症状调查:基于DSM-5的诊断标准

在汶川地震发生5年半后,基于《精神疾病诊断与统计手册》第五版(DSM-5)诊断标准,调查了地震幸存者中可能的创伤后应激障碍(PTSD)的流行情况。本研究调查了1196名汶川地震幸存者,调查内容包括幸存者的人口统计学信息、当前的PTSD症状情况和在汶川地震中的创伤性暴露情况。本研究发现在接受调查者中,可能的PTSD患病率为13.8%;PTSD的风险因素包括:年龄较大、文化程度较低,地震中目睹支离破碎的尸体和家庭成员因地震死亡等。这些结果表明,PTSD是灾后幸存者常见的心理健康问题,且其影响长期存在。     

突发灾难事件引发创伤后应激障碍特点的研究

目的:探讨新疆地区突发灾难事件后医学院大学生创伤后应激障碍发生的特点,为高校学生心理健康指导及民族团结教育提供科学依据。方法:采用PTSD筛查问卷及开放式访谈调查方法对750名医学本科生进行研究。结果:在7.5暴力事件突发后,医学生PTSD的发生率达到12.8%。总体来看,以学生的PTSD症状中,回避维度平均分高于警觉维度的平均分。在性别、民族、学院、年级以及被试的性质上,被试的PTSD存在显著差异。医学生在7.5事件中充当的角色性质、所处学院、所处年级三个变量能联合预测PTSD症状2.7%的变异量。结论:高校学生工作者及高校教师应该根据医学生的特点,及时有效地采取危机干预措施,减少和避免创伤后应激障碍的发生,促进学生心理健康,引导学生建立积极的民族团结意识。     

青少年感恩与创伤后应激障碍症状的关系:社会支持和心理弹性的中介作用

在"5.12"汶川地震后18个月时,采用青少年感恩量表、社会支持评定量表、心理弹性量表和创伤后应激障碍自评量表,对都江堰地区1439名经历地震的青少年进行问卷调查,考察感恩、社会支持、心理弹性与创伤后应激障碍(PTSD)症状的关系。结果表明:(1)感恩、社会支持和心理弹性均与PTSD症状呈显著的负相关,相关系数分别为-0.18,-0.17和-0.24;(2)感恩不仅直接影响PTSD症状,而且还通过社会支持和心理弹性的部分中介作用间接影响PTSD症状,中介效应占总效应的62%。     

创伤后应激障碍患者的HPA轴功能变化的时间序列特征

已知创伤后应激障碍(posttraumatic stress disorder, PTSD)患者表现出HPA轴(hypothalamic-pituitary- adrenocortical axis)功能异常, 而皮质醇是反映PTSD患者HPA轴功能的重要生物标记。近期的研究结果提示, PTSD患者的皮质醇水平变化可能有明显的时间序列特征, 即应激事件发生后先升高, 后下降至正常水平之下。这一特征受到生物标记的时间特性, 患者病程, 应激源类型和强度, 伴生疾病等因素的干扰和掩蔽。未来研究应进一步采用长期追踪设计, 控制干扰因素的影响, 结合急性应激和慢性应激生物标记来综合验证PTSD患者皮质醇水平变化的时间序列特征|并利用该特征预测PTSD的发生、发展, 以便及时进行干预|考虑皮质醇的代谢、拮抗等机制, 结合多种生物标记综合评估、诊断PTSD患者的HPA轴功能活性。     

上海市初中生生活事件、社会支持与应对方式对创伤后应激障碍的影响研究

本研究对上海市1408名初中生进行了调查,探讨应激性生活事件、社会支持和应对方式在创伤后应激障碍(PTSD)形成中的作用机制。结果分析表明：初中生PTSD的发生率为8％,生活事件、社会支持和应对方式确实对PTSD的发生有显著影响,具体来说,家庭因素、社交人际因素、工作学习因素、主观支持、对支持的利用度、自责、求助和幻想对PTSD有显著的影响,而个人健康因素、客观支持、解决问题、退避及合理化则没有显著的影响。各变量之间的交互作用均不显著。     

灾后孤儿创伤后应激障碍的发生发展及其认知神经机制

灾后孤儿亲历双重重大创伤, 是创伤后应激障碍(post-traumatic stress disorder, PTSD)的高发群体; 同时, 巨大创伤对其认知功能和行为模式也带来一定程度的影响。本研究拟以灾后孤儿这一特殊群体为研究对象, 考察“PTSD发生发展及其认知神经机制”, 具体如下：(1) 采用序列研究设计, 展开灾后孤儿PTSD流行病学调查, 描述其PTSD发生发展、变化的轨迹和时程特点; (2) 展开横断研究, 考察灾后孤儿认知发展特点, 并通过结构方程模型, 揭示其PTSD发生发展的心理行为机制; (3) 采用眼动和脑电技术展开比较研究, 考察罹患PTSD孤儿的认知神经机制。本研究的研究结果将对今后的灾后孤儿安置及心理援助提供科学建议; 为有针对性地提供心理干预、制定心理干预的总体规划提供科学依据; 力争为今后孤儿的创伤心理的诊断、干预效果评估提供科学客观的指标和方法。     

创伤后应激障碍与物质使用障碍共病的病因学及其启示

创伤后应激障碍与物质使用障碍共病率高,现有的治疗方法疗效差,总结20年来创伤后应激障碍与物质使用障碍共病研究中病因学方面的新认识,通过对病因的哲学思考可以为今后的治疗方向提供一条思路:两病同治;应提倡药物治疗、认知干预和社会支持综合的治疗手段.     

Posttraumatic Stress and Depression Reactions Among Survivors of the Istanbul November 2003 Terrorist Attacks

This study investigated posttraumatic stress and depression reactions among survivors of the Istanbul November 2003 terrorist bombings that destroyed synagogues, an HSBC bank, and the British General Consulate. One hundred and forty-nine survivors completed a questionnaire measuring exposure, current posttraumatic stress, and depression responses 6 months after the blasts. This study showed that the prevalence rate of posttraumatic stress disorder (PTSD) among survivors was 35.6%?and the rate of depression was 23.5%. PTSD was strongly predicted by perceived life threat, whereas depression was strongly predicted by death of a close friend. Overall, female survivors were found to be more vulnerable to developing posttraumatic stress as well as depression after the terrorist bombings.     

The developmental mental-disorder histories of adults with posttraumatic stress disorder: a prospective longitudinal birth cohort study

Clinical and epidemiologic studies have established that posttraumatic stress disorder (PTSD) is highly comorbid with other mental disorders. However, such studies have largely relied on adults' retrospective reports to ascertain comorbidity. The authors examined the developmental mental health histories of adults with PTSD using data on mental disorders assessed across the first 3 decades of life among members of the longitudinal Dunedin Multidisciplinary Health and Development Study; 100% of those diagnosed with past-year PTSD and 93.5% of those with lifetime PTSD at age 26 had met criteria for another mental disorder between ages 11 and 21. Most other mental disorders had first onsets by age 15. Of new cases of PTSD arising between ages 26 and 32, 96% had a prior mental disorder and 77% had been diagnosed by age 15. These data suggest PTSD almost always develops in the context of other mental disorders. Research on the etiology of PTSD may benefit from taking lifetime developmental patterns of comorbidity into consideration. Juvenile mental-disorder histories may help indicate which individuals are most likely to develop PTSD in populations at high risk of trauma exposure.     

Social anxiety disorder in veterans affairs primary care clinics

To examine the prevalence and correlates of social anxiety disorder (SAD) in veterans, 733 veterans from four VA primary care clinics were evaluated using self-report questionnaires, telephone interviews, and a 12-month retrospective review of primary care charts. We also tested the concordance between primary care providers’ detection of anxiety problems and diagnoses of SAD from psychiatric interviews. For the multi-site sample, 3.6% met criteria for SAD. A greater rate of SAD was found in veterans with than without post-traumatic stress disorder (PTSD) (22.0% vs. 1.1%), and primary care providers detected anxiety problems in only 58% of veterans with SAD. The elevated rate of comorbid psychiatric diagnoses and suicidal risk associated with SAD was not attributable to PTSD symptom severity. Moreover, even after controlling for the presence of major depressive disorder, SAD retained unique, adverse effects on PTSD diagnoses and severity, the presence of other psychiatric conditions, and suicidal risk. These results attest to strong relations between SAD and PTSD, the inadequate recognition of SAD in primary care settings, and the significant distress and impairment associated with SAD in veterans.     

Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample.

The comorbidity of current and lifetime DSM-IV anxiety and mood disorders was examined in 1,127 outpatients who were assessed with the Anxiety Disorders Interview Schedule for DSM-IV: Lifetime version (ADIS-IV-L). The current and lifetime prevalence of additional Axis I disorders in principal anxiety and mood disorders was found to be 57% and 81%, respectively. The principal diagnostic categories associated with the highest comorbidity rates were mood disorders, posttraumatic stress disorder (PTSD), and generalized anxiety disorder (GAD). A high rate of lifetime comorbidity was found between the anxiety and mood disorders; the lifetime association with mood disorders was particularly strong for PTSD, GAD, obsessive-compulsive disorder, and social phobia. The findings are discussed in regard to their implications for the classification of emotional disorders.     

中小学生的灾难暴露程度对创伤后应激障碍的影响：中介和调节效应

汶川地震后1年时,采用灾难暴露程度问卷、主观害怕程度问卷、社会支持问卷和创伤后应激障碍症状量表,对地震极重灾区的3058名中小学生进行调查,考察灾难暴露程度、主观害怕程度、社会支持与创伤后应激障碍的关系。结果发现：（1）震后1年时中小学生创伤后应激障碍的发生率为9.6%,其中有目睹他人死亡经历的学生的创伤后应激障碍发生率为16.2%;（2）灾难暴露程度能正向预测创伤后应激障碍,而主观害怕程度在灾难暴露程度对创伤后应激障碍的影响中起部分中介作用;（3）社会支持在灾难暴露程度与创伤后应激障碍的关系中起调节作用,但不能调节主观害怕程度与创伤后应激障碍之间的关系。其中,无论支持的性质如何,父母和教师的支持都能缓解灾难暴露程度对创伤后应激障碍的影响,而同学和其他人的支持则不具有调节效应。     

Integrated and Holistic Treatment Approach to PTSD and SUD: A Synergy

A review of the literature on integrated and holistic treatment approaches of posttraumatic stress disorder (PTSD) and substance use disorder (SUD) diagnoses is presented. Perspectives on the etiology of PTSD‐SUD comorbidity and the inter‐relation of symptoms are explored.     

Psychotraumatology: A two-factor formulation of posttraumatic stress

Other than the “sudden death” phenomenon, posttraumatic stress represents the most severe and incapacitating form of human stress (Everly, 1989). Posttraumatic stress is directly associated with three DSM-III-R, Axis I disorders: Posttraumatic Stress Disorder (PTSD), Multiple Personality Disorder, and Brief Reactive Psychosis (APA, 1987). It is similarly associated with the Axis II personality disorder Borderline Personality Disorder (Herman and van der Kolk, 1987). Posttraumatic stress may be indirectly related to various forms of mood disorders, substance abuse syndromes, and phobic disorders. Regarding the prevalence of posttraumatic stress, Helzer et al. (1987) found the lifetime prevalence of PTSD at around 1% in the general population. Breslau et al. (1991) found the prevalence of PTSD to be 9% in a cohort of young adults in an urban setting. They further found a prevalence of 24% in young adults who had been exposed to traumatic events. Norman and Getek (1988) have estimated that nearly one-half of all patients admitted to urban trauma centers are likely to suffer from PTSD in addition to their physical traumatization, while another 31% may suffer from a milder variant of posttraumatic stress. These data argue compellingly for the potential severity of the threat that posttraumatic stress poses to society. Yet, no one clear-cut therapy for posttraumatic stress has emerged, nor has a generally agreed-upon phenomenology emerged upon which to base such a therapy. The purpose of this paper is to present a comprehensive formulation of posttraumatic stress based upon an integration of biological and psychological evidence.     

Prevalence and Correlates of Posttraumatic Stress and Postpartum Depression in Parents of Infants in the Neonatal Intensive Care Unit (NICU)

The purpose of this study was to assess the prevalence and correlates of acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) in mothers and fathers, and postpartum depression (PPD) in mothers, of infants in the Neonatal Intensive Care Unit (NICU). 86 mothers and 41 fathers completed measures of ASD and of parent perception of infant medical severity 3–5 days after the infant’s NICU admission (T1), and measures of PTSD and PPD 30 days later (T2). 35% of mothers and 24% of fathers met ASD diagnostic criteria at T1, and 15% of mothers and 8% of fathers met PTSD diagnostic criteria at T2. PTSD symptom severity was correlated with concurrent stressors and family history of anxiety and depression. Rates of ASD/PTSD in parents of hospitalized infants are consistent with rates in other acute illness and injury populations, suggesting relevance of traumatic stress in characterizing parent experience during and after the NICU.     

Relationship of posttraumatic growth to symptoms of posttraumatic stress disorder and depression: A pilot study of Iraqi students

Posttraumatic growth (PTG) and psychopathology are common outcomes following exposure to adversity and trauma. We examined the relationship of PTG to posttraumatic stress disorder (PTSD) and depression in a group of young Iraqi students with war trauma exposure. These young Iraqis had experienced an average of 13 different war‐related adversities. The prevalence of probable PTSD was 17.2% and probable depression 23.1%. PTSD was associated with higher and depression with lower PTG. In addition, the relationship between PTG and PTSD was stronger among males than females. Although PTSD and depression were relatively common, they were related to PTG in opposite directions.