创伤后应激障碍病因及发病机制的研究进展

创伤后应激障碍(post-traumatic stress disorder,PTSD)是一种严重的应激相关障碍,指个体面临异常强烈的精神应激后延迟发生的精神障碍,文献报告PTSD的终生患病率为1%～14%,高危人群研究发现PTSD的患病率为3%～58%,女性约为男性的两倍[1].PTSD的病因及发病机制较为复杂,涉及很多方面,本文将对PTSD病因及发病机制的研究进展进行综述.     

创伤后应激障碍的组蛋白修饰机制

创伤后应激障碍是一种具有复杂病因学的精神疾病,多发生于个体受到重大创伤事件后。创伤后应激障碍的发生发展过程受到环境和遗传易感性的共同作用,存在着较大的个体差异;而表观遗传学作为一门研究多变环境因素调控基因表达的可遗传变化的学科,近年来在创伤后应激障碍的研究中受到越来越多的重视。表观遗传机制之一——组蛋白修饰机制在创伤后应激障碍的发生中起着重要作用,并且由于组蛋白修饰可以受到多种酶的调控,其灵活的可逆化和精细调控为相应的药物研发提供了可能性和便利。因此,深入探讨创伤后应激障碍的组蛋白修饰机制,对于相关疾病的临床治疗及药物研发具有十分重要的意义。当前创伤后应激障碍的组蛋白修饰研究主要使用动物模型,临床研究较少;组蛋白的类型则主要关注组蛋白H3和H4乙酰化;此外,同以往的研究结果一致,组蛋白修饰水平的变化主要发生在前额叶、海马体和杏仁核区域,参与免疫系统、血清素系统和神经肽Y能系统等相关通路的调节。当前PTSD组蛋白修饰的研究结果间还存在较大的异质性,未来的研究应采用更加一致和实用的分析和报道方法,以最大限度地发挥研究的影响。     

交通事故伤幸存者与创伤后应激障碍

交通事故是目前导致创伤后应激障碍(posttraumatic stress disorder,PTSD)的主要原因之一,PTSD常常伴发其他精神障碍如焦虑、抑郁等,即使事故过去很长一段时间以后,症状仍然可能残留或复发,容易迁延形成慢性病程,给患者家庭及社会带来沉重的经济负担。本文综述了交通事故所致PTSD的流行病学、临床症状及影响因素、认知功能损伤、对患者生活质量的影响及对未来研究方向展望。     

创伤后应激障碍的民族差异问题

创伤后应激障碍(PTSD)的民族差异主要体现在少数民族PTSD的发生率较高和症状反应与症状结构的差异。以美国代表的西方国家的研究表明, 这些差异主要是源于暴露水平、少数民族的社会地位以及不同的文化背景。汶川地震后, 有研究也发现羌族PTSD发生率高于汉族, 然而对于羌汉民族间症状反应的具体差异及其原因, 还并不十分明确。因此, 有必要在中国进行PTSD民族差异系统深入的研究, 这既有助于灾后心理援助工作更加有针对性的开展, 也能够为从东方文化视角下理解PTSD提供理论依据。     

创伤后应激障碍的认知理论

创伤后应激障碍是少数具有相对明确病源的精神障碍之一,而且具有独特的临床特 征,如创伤事件的频繁闪现、过度警觉等。关于创伤后应激障碍,存在多种理论解释,该文 对创伤后应激障碍的认知理论作一简要介绍和评述。     

地震后青少年创伤后应激障碍的潜在结构分析

为考察地震后青少年创伤后应激障碍（PTSD）的潜在症状结构,本研究采用儿童创伤后应激障碍症状量表和儿童抑郁量表,对汶川地震一年后的746名中学生进行调查。利用验证性因素分析对竞争模型进行比较,结果发现包括侵入性、回避性、麻木性、精神痛苦性唤起和焦虑性唤起等5个症状的PTSD精神痛苦性唤起模型显著优于DSM-IV的PTSD模型、4维情感麻木模型和4维精神痛苦模型。效度分析的结果发现,PTSD精神痛苦性唤起模型具有良好的外部区分效度。所有结果均表明PTSD精神痛苦性唤起模型在汶川地震后青少年群体中具有良好的适用性,可以作为判定震后青少年PTSD症状的有效标准。     

蓄意创伤受害者的创伤后应激障碍症状及影响因素分析

目的:研究蓄意创伤受害者的PTSD症状及影响因素。方法:采用事件冲击问卷、创伤经历揭露问卷、受害人认可问卷和攻击描述问卷等测查工具对163名蓄意创伤受害者进行调查。结果:(1)蓄意创伤受害者的PTSD三大症状之间相关显著,且方差分析结果差异显著,闯入性症状>回避症状>高警觉症状;(2)创伤严重程度与PTSD三大症状的相关显著;(3)创伤揭露中情绪反应对PTSD三大症状都有显著的预测作用;(4)社会认可度中的一般性排斥对PTSD三大症状都有显著的预测作用。结论:蓄意创伤受害者有着较强的PTSD症状,且以闯入性症状最为严重,回避和高警觉症状次之;创伤的严重程度、揭露时的情绪反应和社会认可度中的一般性排斥等都对蓄意创伤受害者的PTSD症状有影响作用。     

功能性胃肠病的病因和发病机制研究进展

功能性胃肠病（FGIDs）是一组常见的消化科疾病,其病因和发病机制复杂繁多,与遗传和心理社会因素具有一定的关系,胃肠动力、内脏感觉、脑肠肽等在FGIDs发病中的作用已得到肯定,近年来关于炎症和肠道茵群在FGIDs中作用的研究较多,对FGIDs病因机制的阐明将使其诊断和治疗提高到一个新的水平。     

创伤后应激障碍研究进展

文章概括了国内外近年来对创伤后应激障碍的研究,分别介绍了其基本概念、临床分型、理论模型、评估诊断,以及治疗方法。对这一心理障碍的进一步研究能充实心理咨询治疗的课题,并具有重要的社会意义。     

心房颤动的病因、发病机制与射频导管消融治疗现状

随着人们研究的不断深入,对心房颤动的病因、发病机制有了更新的认识.后者从起搏点兴奋性增高,折返机制,发展到对心肌袖、电重构的认识;以及肺静脉、迷走神经在阵发性心房颤动中的作用,遗传物质异质性及基因突变等.同样,心房颤动的射频导管消融治疗也取得了突破性的进展.     

Post-Traumatic Stress Disorder Symptoms of Children Following the Occurrence of Tehran City Park Disaster

The authors investigated the post-traumatic stress disorder (PTSD) symptoms of young adolescents who had been directly involved in a disaster in Tehran. The participants were 19 chlidren who had survived a boat sinking in Tehran's city park in 2002. By using the Post-Traumatic Stress Disorder Symptom Scale (PSS; E. B. Foa, D. S. Riggs, C. V. Dancu, & B. O. Rothbaum, 1993) as well as a clinical interview based on the definition cited in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; American Psychiatric Association, 1994, p. 424), 16 participants (84.2%) were diagnosed with PTSD using the PSS and 17 (89.5%) were diagnosed with PTSD using the psychiatric interview.     

Post-Traumatic Stress Disorder,Sensory Integration,and Aquatic Therapy: A Scoping Review

The prevalence of post-traumatic stress disorder (PTSD) continues to increase. Symptomology of PTSD include sensory deficits much like those displayed in children with sensory integration (SI) disorder. The aim of this scoping review is to review symptoms of PTSD and SI, and make a case of how aquatic therapy may be an effective modality in treating clients with PTSD. Eighteen articles were selected for review. From this review, it is suggested that aquatic therapy can be an effective modality in reducing symptoms of PTSD; however, future research is essential in determining its effectiveness.     

Attachment Theory and Post-Traumatic Stress Disorder

Attachment theory is applied to understanding and treatment of the anxiety condition of post-traumatic stress disorder in adults. Conceptualized as intensified attachment behavior which is elicited at separation or loss or threat of separation, PTSD responses represent an inherent, though exaggerated, attempt to ensure protection and security. The secure base of a therapeutic relationship reduces the intensity of responses and provides an opportunity to review experiences relevant to current distress in order to affirm emotional reactions and come to terms with distressing events. Implications for prevention are discussed.     

Comorbidity of attention Deficit Hyperactivity Disorder and Post-Traumatic Stress Disorder

Attention Deficit Hyperactivity Disorder (ADHD) and Post-Traumatic Stress Disorder (PTSD) show a high degree of comorbidity in traumatized children. Two hypotheses may help explain this relationship: children with ADHD are at higher risk for trauma due to their impulsivity, dangerous behaviors, and parents who may have a genetic predisposition for impairment of their own impulse control; and hyperarousal induced by severe trauma and manifested by hypervigilance and poor concentration may impair attention to create an ADHD-like syndrome. Four illustrative cases are presented, and implications for treatment are discussed.     

The Forensic Examination of Posttraumatic Stress Disorder

Abstract

The diagnosis of posttraumatic stress disorder (PTSD) has achieved a major level of significance in our judicial system. The forensic examination of PTSD is identified as a specialized assessment that is non-biased and non-prejudicial. This article attempts to provide a standard methodology to offer an objective and neutral forensic assessment and diagnosis of PTSD that will stand up to legal scrutiny by identifying problems in diagnosing PTSD and establishing a six-step methodology for the differential diagnosis of the disorder. Procedures for providing a forensic examination of PTSD and details of the author's methods of providing a forensic examination are presented.     

The time of trauma: Husserl's phenomenology and Post-Traumatic Stress Disorder

The phenomenology of inner temporalizing developed by Edmund Husserl provides a helpful framework for understanding a type of experiencing that can be part of the Post-Traumatic Stress Disorder (PTSD). My paper extrapolates hints from Husserl's work in order to describe those memories — flashbacks — that come so strongly to consciousness as to overtake the experiencer. Husserl's work offers several clues: his view of inner temporalization by which conscious experiences flow in both a serial and a nonserial manner; a characterization of process memory as distinct from representational memory; and the notion of telos, which takes human subjectivity as intrinsically changeable, for example, by means of a retroactive cancellation that would allow the PTSD experiencer to re-process the original meaning of the traumatic experience into a meaning that fits the current situation and thus allows a recovery.     

The Use of Psychoendocrine Strategies in Post-Traumatic Stress Disorder1

An overview is presented of a pilot psychoendocrine study of PTSD inpatients in comparison with several subgroups of schizophrenic and affective disorder patients. Using a hormonal profile including Cortisol, norepinephrine, epinephrine, testosterone, and thyroxine, it was found that the mean values for the PTSD group were at or near the extreme end of the range for every hormone measured, i.e., relatively low for Cortisol and high for the remaining hormones. The possible clinical meaning of these findings is considered in the light of prior psychoendocrine research on chronic stress. The hormonal alterations in PTSD appear to be persistent and suggest the possibility of being linked largely to traits or character structure, perhaps particularly to cognitive variables related to defense and coping mechanisms, as reviewed in detail for each hormonal system. There appears to be a potential for a fruitful union between the traumatic stress and psychoendocrine fields and some future strategies for developing and strengthening such a union are suggested.