妊娠期肝内胆汁淤积症胎儿不良预后原因探索

妊娠期肝内胆汁淤积时,在各种机制作用下,往往在妊娠晚期发生胎儿猝死等不良预后,但机制尚不清楚,还在不断的探索之中。主要从胎盘结构因素、胆汁酸的作用、血管及血管调节因素三个方面分析妊娠期肝内胆汁淤积症不良预后的原因,旨在研究妊娠期肝内胆汁淤积症患者胎儿不良预后的原因中所体现的哲学观点。     

妊娠期肝内胆汁淤积症胎儿不良预后原因探索

妊娠期肝内胆汁淤积时,在各种机制作用下,往往在妊娠晚期发生胎儿猝死等不良预后,但机制尚不清楚,还在不断的探索之中.主要从胎盘结构因素、胆汁酸的作用、血管及血管调节因素三个方面分析妊娠期肝内胆汁淤积症不良预后的原因,旨在研究妊娠期肝内胆汁淤积症患者胎儿不良预后的原因中所体现的哲学观点.     

妊娠肝内胆汁淤积症的回顾和启示

18 8 3年Ａｈｌｆｅｌｄ首次报道一种发生于妊娠晚期而在以后妊娠中有复发倾向的一种黄疸疾病 ,从此拉开了人类认识妊娠肝内胆汁淤积症 (ｉｎｔｒａｈｅｐａｔｉｃｃｈｏｌｅｓｔａｓｉｓｏｆｐｒｅｇｎａｎｃｙ ,ＩＣＰ)的帷幕。至 195 4～195 5年 ,Ｓｖａｎｂｏｒｇ与Ｔｈｏｒｌｉｎｇ在斯堪的那维亚报道较多病例 ,并对本病的临床、生化、组织学改变进行了研究 ,才明确提出是独立新的疾病[1,2 ] 。 10 0多年来 ,ＩＣＰ的研究 ,从Ａｈｌｆｅｌｄ首次捕捉ＩＣＰ琐碎现象 ,到 2 1世纪无数学者致力于流行病学调查 ,临床观察及实验室研究 ,人类…     

妊娠期肝内胆汁淤积症研究中的认识论

妊娠期肝内胆汁淤积症是一种常见的妊娠晚期并发症,临床上以皮肤瘙痒和黄疸为特征,伴有胆汁酸、肝酶等生化指标的异常。其对母体影响较小,但可以引起早产、胎窘和不明原因的死胎,对围生儿的严重危害使其受到了产科医生的重视。因此,有必要通过回顾妊娠期肝内胆汁淤积症的认识过程来看医学认识发展中所体现的哲学观点。     

妊娠期肝内胆汁淤积症研究中的认识论

妊娠期肝内胆汁淤积症是一种常见的妊娠晚期并发症,临床上以皮肤瘙痒和黄疸为特征,伴有胆汁酸、肝酶等生化指标的异常。其对母体影响较小,但可以引起早产、胎窘和不明原因的死胎,对围生儿的严重危害使其受到了产科医生的重视。因此,有必要通过回顾妊娠期肝内胆汁淤积症的认识过程来看医学认识发展中所体现的哲学观点。     

妊娠期肝内胆汁淤积症研究中的因果论

妊娠期肝内胆汁淤积症是一种常见的妊娠晚期并发症,对围产儿的危害极大,其确切的病因及发病机制尚未十分清楚.只有了解了疾病的起因,才能更好地进行防治.凡病必有其因,以果推因,再取因治果,这是典型的因果论的应用.     

妊娠期肝内胆汁淤积症研究中的因果论

妊娠期肝内胆汁淤积症是一种常见的妊娠晚期并发症,对围产儿的危害极大,其确切的病因及发病机制尚未十分清楚。只有了解了疾病的起因,才能更好地进行防治。凡病必有其因,以果推因,再取因治果,这是典型的因果论的应用。     

多角度认识妊娠期肝内胆汁淤积症

妊娠期肝内胆汁淤积症是妊娠晚期特发性疾病,以皮肤瘙痒、胆汁酸增高及肝功能损害为特征.对孕产妇危害较小,对围产儿产生严重后果,使围产儿患病率、死亡率增加.其发病机制尚不明确,许多研究表明它是一种多因素疾病.任何事物都是辨证统一的,在临床中运用辨证的眼光看待疾病,可以促进对疾病的认识.     

对妊娠晚期畸形胎儿实施致死性引产的可行性分析

在妊娠晚期发现胎儿畸形,许多胎儿父母要求引产。一些患儿父母因为在医院引产出活体畸形婴儿而与医院产生纠纷。本文考虑采用医疗方法在引产前或引产中使胎儿心跳停止,确保引产出的胎儿为死婴（即致死性引产）以减少纠纷,利于社会。本文试图从医疗、伦理、法律的角度,探讨在胎儿父母要求下,对妊娠晚期畸形胎儿实施致死性引产的可行性。     

无意识认知的探索

本文介绍了无意识认知的研究历程和特点,其中着重阐述了内隐记忆和内隐学习两个领域,并评述了内隐记忆和内隐学习在研究历程、特点和理论三方面的相似点,在此基础上表达了对无意识认知领域的整合趋势的期待。     

Crib death: a biobehavioral phenomenon?

In developed countries, more children under 1 year of age die of crib death (sudden infant death syndrome, SIDS) than of all other causes combined. Researchers and clinicians have proposed many possible causes of SIDS, but the abrupt, unexpected death of some babies remains mysterious and frightening. Although infant behavior may explain some of these deaths, scant attention has addressed behavioral characteristics of babies who die without medical explanation. Any explanation of SIDS must account for the fact that most SIDS deaths occur at 2 to 5 months of age, acknowledging that a protective mechanism appears to spare babies before 2 months but then disappears. The respiratory occlusion reflex serves as an initial defense against smothering and can provide such an explanation. Infantile reflexes wane, after providing opportunities for learned responses to be acquired. During this well-documented neurobehavioral transition from subcortical to cortically mediated responding, some babies, viable for the first 2 months, may become especially vulnerable if they fail to acquire sufficiently strong defensive behaviors needed to prevent occlusion after the waning of the life-preserving reflex. Recent success of back-to-sleep directives, urging that babies sleep on their backs to avoid smothering, supports this hypothesis.     

MDR3基因在妊娠期肝内胆汁淤积症中的研究及思考

妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)病因复杂,目前研究认为遗传因素在其发病机制中起着相当关键的作用。其中MDR3基因与ICP的发病尤为密切。文章从哲学的角度对MDR3基因的发现过程以及未来的发展前景展开了综合分析。     

Fetal Programming: Prenatal Origins of Health and Illness

ABSTRACT— Research on young animals and humans has demonstrated the critical importance of the fetal stage as a formative period in normal development. However, the significance of these findings has not always been incorporated into our thinking when trying to elucidate the origins of health and disease. It is not only that babies react to the state of the mother and to salient environmental events while still in the uterus. This stimulation and priming seems to be essential for guiding the optimal maturation of the nervous, endocrine, and immune systems. Experiences during prenatal life also program the regulatory set points that will govern physiology in adulthood. During this malleable maturational phase, these biological processes should be viewed as flexible "learning systems" that guide the developmental trajectory toward health or derail it toward pathology. Our studies on infant primates have shown that the competence of their immune responses and the structure and activity of certain brain regions, as well as many aspects of behavior and emotional reactivity, are strongly affected by the pregnancy conditions of their mothers.     

猝死、医疗纠纷与尸体剖检

貌似“健康”的人突然死亡(即猝死),由于事先无任何预兆,出乎人们意料往往使人们对死因产生怀疑,若死者是在因病就医过程中突然死亡,特别是在刚注射或服药后死亡,很容易被认为是医护人员的医疗活动及其相关活动有问题而引发医疗纠纷,每位医务人员应高度重视,若死因不明,尸检则是解决这一棘手问题的关键。     

胆汁酸再认识的进展

早在古希腊人们对胆汁就有所认识,而祖国医学很早就使用动物胆汁来治疗疾病。现代医学则应用胆汁酸来治疗肝胆疾病,如鹅脱氧胆酸和熊脱氧胆酸。近年来对胆汁酸的研究又有了新的突破。因此,我们有必要对其生理功能进行再认识,为临床相关疾病的病因和治疗提供新思路。