Causal Reasoning and Clinical Practice: Challenges from Molecular Biology

Not only has the philosophical debate on causation been gaining ground in the last few decades, but it has also increasingly addressed the sciences. The biomedical sciences are among the most prominent fields that have been considered, with a number of works tackling the understanding of the notion of cause, the assessment of genuinely causal relations and the use of causal knowledge in applied contexts. Far from denying the merits of the debate on causation and the major theories it comprises, this paper is meant as a stimulus for theorists of causation in the philosophy of biomedicine, with a focus on clinical matters. Without aiming at putting forward an original theory of causation and starting from the narration of two actual but paradigmatic cases at the joints between biomedical research and clinical practice, we want to point out that some pathological situations addressed by molecular medicine actually prove resistant to (at least) some of our major epistemological accounts of causal explanation. Given this scenario, which is very frequent in our hospitals, our analysis aims to provide a stimulus for the debate among theorists of causation in biomedicine interested in real cases in science in practice. We believe that this might in turn encourage some more general rethinking of the complex intertwinement of science, philosophy of science and ethics, as well as of the role of philosophy of science for clinical medicine itself.

     

Interrogating the Learning Sciences as a Design Science: Leveraging Insights from Chinese Philosophy and Chinese Medicine

Design research has been positioned as an important methodological contribution of the learning sciences. Despite the publication of a handbook on the subject, the practice of design research in education remains an eclectic collection of specific approaches implemented by different researchers and research groups. In this paper, I examine the learning sciences as a design science to identify its fundamental goals, methods, affiliations, and assumptions. I argue that inherent tensions arise when attempting to practice design research as an analytic science. Drawing inspiration and insight from Chinese philosophy and the practice of Chinese medicine, I propose that the learning sciences may better attain its claims to science through greater reliance on inductive synthesis rather than linear causal analysis. In so doing, I reposition the endeavor of science making within the metaphysics of process philosophy instead of classical Western philosophy. I suggest that theory building will be strengthened empirically and pragmatically by more careful observation and systematic generalization of the stability patterns of design related phenomena. It also needs to be more situated in its orientation.     

Population psychology in perspective(1)

Many aspects of population, from fertility regulation to migration, may be viewed as examples of human behavior occurring within a particular socio-economic and environmental context, and thus appropriate for psychological research. Especially considered in this paper are (1) the current status of population growth and the importance of population processes as research topics for psychologists; (2) basic assumptions concerning the complementarity of behavioral and biomedical sciences in population research; (3) behavioral science contributions, specifically from psychology; and (4) recommendations for cooperative multidisciplinary efforts.     

Are Science and Religion in Conflict?

The widely held legend of historical conflict between science and religion cannot be sustained on the basis of research. Different sciences show different relationships to religion; the physical sciences show rapprochement, whereas the human sciences often are antagonistic to religion. Reconciling science and religion by regarding each as applicable to a different domain is rejected in favor of seeing them as complementary perspectives on the same phenomena. The science and theology of human nature represents a fruitful arena for the development of this approach. A key general requirement is the epistemological reconciliation of science and religion.     

Embedding philosophers in the practices of science: bringing humanities to the sciences

The National Science Foundation (NSF) in the United States, like many other funding agencies all over the globe, has made large investments in interdisciplinary research in the sciences and engineering, arguing that interdisciplinary research is an essential resource for addressing emerging problems, resulting in important social benefits. Using NSF as a case study for problem that might be relevant in other contexts as well, I argue that the NSF itself poses a significant barrier to such research in not sufficiently appreciating the value of the humanities as significant interdisciplinary partners. This essay focuses on the practices of philosophy as a highly valuable but currently under-appreciated partner in achieving the goals of interdisciplinary research. This essay advances a proposal for developing deeper and wider interdisciplinary research in the sciences through coupled ethical-epistemological research. I argue that this more robust model of interdisciplinary practice will lead to better science by providing resources for understanding the types of value decisions that are entrenched in research models and methods, offering resources for identifying the ethical implications of research decisions, and providing a lens for identifying the questions that are ignored, under-examined, and rendered invisible through scientific habit or lack of interest. In this way, we will have better science both in the traditional sense of advancing knowledge by building on and adding to our current knowledge as well as in the broader sense of science for the good of, namely, scientific research that better benefits society.     

The harms of ignoring the social nature of science

In this paper I argue that philosophers of science have an obligation to recognize and engage with the social nature of the sciences they assess if those sciences are morally relevant. Morally-relevant science is science that has the potential to risk harm to humans, non-humans, or the environment. My argument and the approach I develop are informed by an analysis of the philosophy of biology literature on the criticism of evolutionary psychology (EP), the study of the evolution of human psychology and behaviour. From this literature, I tease out two different methods of scientific critique. The first I call the “truth-detectional” approach. Those who take this approach are first and foremost concerned about the truth of EP claims as that truth can be determined by evidence. The second I call the “social-dimensional” approach. Those who take this approach talk about the production and truth of EP claims but within a social framework. On this account, the legitimacy and perceived legitimacy of EP claims are not separate from the institutional and social processes and values that lend to their production. I show that the truth-detectional approach risks harms to society and to the philosophy of science, but that the social-dimensional approach avoids these harms. Philosophers of science, therefore, should take a social-dimensional approach to the assessment of morally-relevant science.

     

Science as Structured Imagination

This paper offers an analysis of scientific creativity based on theoretical models and experimental results of the cognitive sciences. Its core idea is that scientific creativity — like other forms of creativity — is structured and constrained by prior ontological expectations. Analogies provide scientists with a powerful epistemic tool to overcome these constraints. While current research on analogies in scientific understanding focuses on near analogies, where target and source domain are close, we argue that distant analogies — where target and source domain differ widely — are especially useful in periods of intense conceptual change. To argue this point, we discuss three case studies from the history of science: early physiologists like Harvey, early evolutionary biologists like Darwin, and recent theorists on the evolution of the human mind like Mithen.     

Historical and Philosophical Perspectives on Experimental Practice in Medicine and the Life Sciences

The aim of this paper is to discuss a key question in the history and philosophy of medicine, namely how scholars should treat the practices and experimental hypotheses of modern life science laboratories. The paper seeks to introduce some prominent historiographical methods and theoretical approaches associated with biomedical research. Although medical scientists need no convincing that experimentation has a significant function in their laboratory work, historians, philosophers, and sociologists long neglected its importance when examining changes in medical theories or progress in scientific knowledge. The reason appears to have been the academic influence of the then dominant tradition in the history of ideas, but was also due to a misconception of what could usefully be termed the view on “historical ontology.” During the last two decades, there have been many books and research articles that have turned towards the subject, so that the study of experimental practice has become a major trend in the contemporary history and philosophy of medicine. A closer look at the issue of laboratory research shows that concepts in medicine and the life sciences cannot be understood as historically constant, free-standing ideas, but have to be regarded as dependent on local research settings. They often carry particular “social memories” with them and thus acquire important ethical implications.     

Evolution and medicine: the long reach of "Dr. Darwin"

In this review we consider the new science of Darwinian medicine. While it has often been said that evolutionary theory is the glue that holds the disparate branches of biological inquiry together and gives them direction and purpose, the links to biomedical inquiry have only recently been articulated in a coherent manner. Our aim in this review is to make clear first of all, how evolutionary theory is relevant to medicine; and secondly, how the biomedical sciences have enriched our understanding of evolutionary processes. We will conclude our review with some observations of the philosophical significance of this interplay between evolutionary theory and the biomedical sciences.     

A Critically Appreciative Valuation of Social Constructionist Contributions to Organizational Science

Modernist approaches to research in the social sciences dominate academia, including much of organization science. Discovery through reason, observation, and analysis are the quintessential modernist quests. However, this reductionist approach to essentialize the social through the usage of language, a product of culture with its inevitable entanglement with cultural ideology, values, sensibility, intelligibility, and history, is akin to capturing a moving target on shifting grounds. Positing social constructionism as an alternative, we explain it has revolutionalized the social sciences and organization science alike; offer an array of social constructionist inquiry methodologies to fuel generative possibilities for organization research; compare and contrast modernist and social constructionist organization theories, research methodologies and assumptive metaphors to accentuate the textual and dialogic potential social constructionism brings to organization science; and conclude with creative ways social constructionism can realize actionable knowledge through co-creation among communities.     

Hybrid analogies in conceptual innovation in science

Analogies are ubiquitous in science, both in theory and experiments. Based on an ethnographic study of a research lab in neural engineering, we focus on a case of conceptual innovation where the cross-breeding of two types of analogies led to a breakthrough. In vivo phenomena were recreated in two analogical forms: one, as an in vitro physical model, and the other, as a computational model of the first physical model. The computational model also embodied constraints drawn from the neuroscience and engineering literature. Cross connections and linkages were then made between these two analogical models, over time, to solve problems. We describe how the development of the intermediary, hybrid computational model led to a conceptual innovation, and subsequent engineering innovations. Using this case study, we highlight some of the peculiar features of such hybrid analogies that are now used widely in the sciences and engineering sciences, and the significant questions they raise for current theories of analogy.     

The big picture: Writing psychology into the history of the human sciences

The grand narratives which once gave order and readability to histories, of science and of the human sciences are widely rejected in current historiography, and historians focus on detailed studies of scientific knowledge and activity in particular contexts. How, then, are synthetic general histories, accessible to the non-specialist, to be written? This paper, designed as an open-ended discussion, reflects on the business of writing about psychology in a general history of the human sciences. It considers three large topics: reflexivity, and the situation in the human sciences where “man” is both subject and object; the boundary-less identity of the human sciences and hence the need to express values in delimiting the content of the field; and the long-standing debate about what sort of “science” is appropriate for knowledge of human beings. The conclusion turns to “the quest” as a narrative form. © 1998 John Wiley & Sons, Inc.     

Social Science as a Guide to Social Metaphysics?

If we are sympathetic to the project of naturalising metaphysics, how should we approach the metaphysics of the social world? What role can the social sciences play in metaphysical investigation? In the light of these questions, this paper examines three possible approaches to social metaphysics: inference to the best explanation from current social science, conceptual analysis, and Haslanger-inspired ameliorative projects.     

Diseases as natural kinds

In this paper, I focus on life-threatening medical conditions and argue that from the point of view of natural properties, induction(s), and participation in laws, at least some of the ill organisms dealt with in somatic medicine form natural kinds in the same sense in which the kinds in the exact sciences are thought of as natural. By way of comparing two ‘divisions of nature’, viz., a ‘classical’ exact science kind (gold) and a kind of disease (Graves disease), I show that there is no justifiable ‘ontological gap’ between disease kinds and exact sciences kinds. We have instead a difference of degree.     

Advancing Psychology as a Bio-behavioral Science

Concerns for the integrity of psychology as an independent discipline have caused some psychologists to object to introducing any knowledge from the biological sciences into the training of psychologists. However, calls for the greater incorporation of the behavioral sciences in medical education, increased attention to research on the mechanisms of bio-behavioral interaction, and initiatives in translational medical research and clinical care, have prompted increased interest in interdisciplinary research, health care, and teaching. These changes, in turn, are resulting in a re-conceptualization of the structure of academic medicine with increasing emphasis upon multidisciplinary knowledge and interdisciplinary collaboration, and less emphasis upon disciplinary insularity and competitiveness. If clinical health psychology is to play a role in this evolving concept of academic health care, it must adequately prepare its trainees to function in interdisciplinary academic health care settings. This will require not only expertise in the role of behavioral factors relevant to medical disorders, but also some basic familiarity with the biological processes to which those behavioral factors relate. With the evolution of its fund of knowledge, clinical health psychology has the potential to utilize its science to discover, describe, interpret, teach and clinically apply knowledge of the mechanisms of interaction between biological functions and behavioral, learning, cognitive, socio-cultural and environmental processes. By failing to seize this initiative, clinical health psychology risks becoming irrelevant to the evolving model of medical research, education and health care. Presented, in part, to the Association of Psychologists in Academic Health Centers, Minneapolis, MN, May 2007.     

Scientific Reforms,Feminist Interventions,and the Politics of Knowing: An Auto‐ethnography of a Feminist Neuroscientist

Feminist science studies scholars have documented the historical and cultural contingency of scientific knowledge production. It follows that political and social activism has impacted the practice of science today; however, little has been done to examine the current cultures of science in light of feminist critiques and activism. In this article, I argue that, although critiques have changed the cultures of science both directly and indirectly, fundamental epistemological questions have largely been ignored and neutralized through these policy reforms. I provide an auto‐ethnography of my doctoral work in a neuroscience program to a) demonstrate how the culture of science has incorporated critiques into its practices and b) identify how we might use these changes in scientific practices to advance feminist science agendas. I critically analyze three areas in current scientific practice in which I see obstacles and opportunities: 1) research ethics, 2) diversity of research subjects and scientists, and 3) identification of a project's significance for funding. I argue that an understanding of the complicated and changing cultures of science is necessary for future feminist interventions into the sciences that directly challenge science's claim to epistemic authority.     

A Plea for a Historical Epistemology of Research

The paper approaches the topic of what a general philosophy of science could mean today from the perspective of a historical epistemology. Consequently, in a first step, the paper looks at the notion of generality in the sciences, and how it evolved over time, on the example of the life sciences. In the second part of the paper, the urgency of a general philosophy of science is located in the history of philosophy of science. Two attempts at the beginning of the twentieth century are particularly highlighted: that of Karl Popper and that of Martin Heidegger. Both of them concentrate, albeit in widely different form, on the phenomenon of research as an open-ended process. This trend is even more pronounced in Gaston Bachelard??s version of a historical epistemology, whose work is taken as a point of reference for a general historical epistemology of research. The paper concludes with a plea to look, with Georges Canguilhem, at the history of the sciences as a laboratory for epistemology.     

腹腔镜手术治疗子宫内膜异位症的临床价值

子宫内膜异位症是妇科常见病、多发病之一,可引起痛经、慢性盆腔痛、性交痛和不孕等症状,严重影响育龄期妇女的身心健康和生活质量,日益受到人们的关注。以人为本,微创手术是当代医学的模式之一。本文从哲学的角度出发、以辩证的观点对腹腔镜手术治疗子宫内膜异位症的临床价值进行综述。     

Water quality, agricultural policy and science

This paper analyses how agricultural policy and science deal with the problem of increasing exploitation of low quality irrigation water and consequent deterioration of water quality in the States of Punjab and Haryana in India. In these cereal growing tracts the policy objective of food security is translated into production technologies, price protection and subsidies. Deterioration of water quality is countered with technocentric solutions. The paper argues that the response of science to the complexities involved in natural resource problems or in the scientific understanding of farmers partial response to technological solutions recommended to improve degraded resources, is due to the existing “administrative rationalism” of natural resource bureaucracies. This administrative rationalism, “the problem-solving discourse which emphasizes the role of the expert rather than the citizen” allows policy and science to maintain their hierarchy in determining policy goals and technological solutions with scant ecological or democratic concerns. Sustainable use of water demands institutional reform in agricultural policy and the agricultural sciences. With an inter-disciplinary training in the agricultural sciences and economics, her publications address the history of and institutional reform in agricultural science, the evaluation of agricultural research, and the organization and measurement of agricultural research effort. This paper is based on an in-house project on “Ex-post evaluation of soil science technologies,” conducted during 1997–2001, in collaboration with Sunita Sangar (then QHS Fellow, NISTADS) whose Ph.D. thesis on the same topic has been submitted to IIT, Delhi in January 2002. Sunita Sangar has a degree in the life sciences, and is interested in science and technology policy issues related to soil and water resources. The authors are currently working on the NATP sponsored project, on an ecological economics framework for the evaluation of soil science research in India.     

Ethical Assurance Statements in Political Science Journals

Many journals in the physical sciences require authors to submit assurances of compliance with human subjects and other research ethics standards. These requirements do not cover all disciplines equally, however. In this paper we report on the findings of a survey of perceptions of ethical and managerial problems from journal editors in political science and related disciplines. Our results show that few journals in political science require assurance statements common to journals for other scientific disciplines. We offer some reasons for this as well as some recommendations for implementing ethical assurance safeguards for political science.