肝性糖尿病

肝性糖尿病由严重慢性肝脏病变所引发,常见于非酒精性脂肪肝、病毒性肝炎、酒精性肝病及血色病等,多出现于肝硬化失代偿期,不论是发病机制,还是临床表现与治疗均与2型糖尿病不同。本文将就此方面对近几年的研究进展进行综述。     

非酒精性脂肪性肝病的治疗进展

非酒精性脂肪性肝病的发病率逐渐上升,近年已成为危害全球公共健康的重要疾病之一。其治疗在于通过改变生活方式、增加胰岛素敏感性、抗炎保肝等措施纠正代谢紊乱、改善肝脏损害,以阻止疾病发生发展。本文就基础治疗、药物治疗及手术治疗三方面概述目前非酒精性脂肪性肝病的治疗进展。     

非酒精性脂肪性肝病肝功能改变特点

脂肪肝的定义是由于各种原因使脂肪在肝内堆积超过5%,很多原因均可引起脂肪肝。非酒精性脂肪性肝病是脂肪肝的一种,近年来其发病率逐渐增加。由于其起病隐匿、症状不明显,其诊断主要依靠肝功能检测及肝脏影像学检查来诊断。本文将就其所致肝功能异常的生化学特点加以论述,来帮助提高临床上非酒精性脂肪性肝病诊断率。     

非酒精性脂肪性肝病肝功能改变特点

脂肪肝的定义是由于各种原因使脂肪在肝内堆积超过5%,很多原因均可引起脂肪肝.非酒精性脂肪性肝病是脂肪肝的一种,近年来其发病率逐渐增加.由于其起病隐匿、症状不明显,其诊断主要依靠肝功能检测及肝脏影像学检查来诊断.本文将就其所致肝功能异常的生化学特点加以论述,来帮助提高临床上非酒精性脂肪性肝病诊断率.     

酒精性肝损伤的防治思考

酒精性肝损伤已成为继病毒性肝炎后的主要肝损伤病因,因此酒精性肝病的防治已经成为重要的医疗课题。其病因、发病机制、病理改变及治疗等有其独特的特点,用哲学的方法对其进行科学、全面的分析,可有助于对该病的认识和研究,指导我们从总体考虑,更为合理、有效地防治酒精性肝损害。     

胰岛素抵抗与非酒精性脂肪性肝病

非酒精性脂肪性肝病是一种以肝细胞脂肪变性和脂肪贮积为病理特征但无过量饮酒史的临床综合征。肥胖、2型糖尿病和高脂血症被认为是非酒精性脂肪性肝病的重要危险因素。有研究表明胰岛素抵抗与非酒精性脂肪性肝病密切相关。脂质代谢异常、氧应激反应、瘦素、脂联素等与胰岛素抵抗的发生有相互作用,也影响着非酒精性脂肪肝病的发生发展。胰岛素抵抗在非酒精性脂肪性肝病发病机制上的作用以及与胰岛素抵抗相关的发病因素值得关注。通过体育锻炼与控制饮食热量逐渐减轻体重,并配合血糖及血脂的控制对非酒精性脂肪性肝病患者十分重要。     

胰岛素抵抗与非酒精性脂肪性肝病

非酒精性脂肪性肝病是一种以肝细胞脂肪变性和脂肪贮积为病理特征但无过量饮酒史的临床综合征.肥胖、2型糖尿病和高脂血症被认为是非酒精性脂肪性肝病的重要危险因素.有研究表明胰岛素抵抗与非酒精性脂肪性肝病密切相关.脂质代谢异常、氧应激反应、瘦素、脂联素等与胰岛素抵抗的发生有相互作用,也影响着非酒精性脂肪肝病的发生发展.胰岛素抵抗在非酒精性脂肪性肝病发病机制上的作用以及与胰岛素抵抗相关的发病因素值得关注.通过体育锻炼与控制饮食热量逐渐减轻体重,并配合血糖及血脂的控制对非酒精性脂肪性肝病患者十分重要.     

肝脾CT值分析在非酒精性脂肪肝诊断中的应用

探讨肝脾CT值分析在非酒精性脂肪肝中诊断及严重程度的关系.对163例临床明确诊断的非酒精性脂肪肝患者,分别根据肝脏CT值、肝脾CT值比值及肝脾CT值差值进行分组.结果三种评价方法对重度非酒精性脂肪肝均有较高的灵敏度及特异度,轻度非酒精性脂肪肝样本中出现28例肝脾CT比值>1,肝脾值差值与肝脾CT值比值在对脂肪肝严重程度上有明显的相关性,肝脏CT值与肝脾CT值比值在对脂肪肝严重程度上没有明显的相关性.肝脾CT值分析在重度NAFLD诊断中有较高的准确性.肝CT值高于脾CT值不能完全排除NAFLD.肝脾CT值差值也可作为NAFLD严重程度量化的参考评定标准.肝脏CT值不宜作为NAFLD严重程度评定标准.     

肝脾CT值分析在非酒精性脂肪肝诊断中的应用

探讨肝脾CT值分析在非酒精性脂肪肝中诊断及严重程度的关系。对163例临床明确诊断的非酒精性脂肪肝患者,分别根据肝脏cT值、肝脾CT值比值及肝脾CT值差值进行分组。结果三种评价方法对重度非酒精性脂肪肝均有较高的灵敏度及特异度,轻度非酒精性脂肪肝样本中出现28例肝脾CT比值〉1,肝脾值差值与肝脾CT值比值在对脂肪肝严重程度...     

肥胖和/或NAFLD患者的药物性肝损伤

与药物有关的肝毒性是一个严重的健康问题,广泛影响着患者、医疗机构和政府监管机构.另外,由于久坐的生活方式和热量过度摄取,我们还面临着肥胖和非酒精性脂肪性肝病（NAFLD）的流行和困扰,因为肥胖和/或NAFLD提高各种疾病的风险,成为影响公众健康的又一个主要问题,这些患者平均使用药物的量远高于非肥胖患者.越来越多的证据表明,某些药物能够增加肥胖和NAFLD患者药物诱发肝损伤（DILI）的风险.因此,我们应该重视和防治肥胖和NAFLD患者DILI的发生.     

An operant treatment procedure for alcoholics

For many years total abstinence was regarded as the appropriate criterion for the successful treatment of alcoholism. It is suggested that given societal norms for social consumption of alcohol, plus the social reinforcers which maintain beverage alcohol ingestion, social drinking may serve as a realistic treatment goal. The efficacy of a social drinking criterion was clearly demonstrated by Bigelow et al. (1972). Chronic alcoholic in-patients were placed in a choice situation in which they earned the opportunity to participate in an ‘enriched’ environment contingent upon either moderate drinking or abstinence. Subjects overwhelmingly chose the moderate drinking alternative. Results also suggested that moderate drinking is more reinforcing than abstinence for alcoholics. Further support for the moderate drinking concept was rendered by Mills, Sobel and Schaeffer (1971) in a study which made electric shock contingent on gulping drinks, ordering straight alcoholic drinks and ordering and consuming more than three drinks. Time-out (Cohen et al., 1971), positive reinforcement (Cohen et al., 1971) and social contracting procedures (Miller, 1972) have been effectively employed to reduce drinking behavior from maladaptive to adaptive frequencies.

The present study attempts to extend treatment with a controlled drinking outcome to out-patient alcoholics     

Fitting in and feeling fine: conformity and coping motives as mediators of the relationship between social anxiety and problematic drinking.

The present research was conducted to clarify the relationships among social anxiety, alcohol consumption, alcohol-related problems, and negative-reinforcement drinking motives among college students. Heavy drinking students (N = 316, 53.80% female) completed self-report measures of social anxiety, alcohol consumption, alcohol-related problems, and drinking motives. Findings indicated that students higher in social anxiety consumed less alcohol but experienced more negative consequences. Moreover, the relationship between social anxiety and negative consequences was mediated by coping and conformity drinking motives in addition to alcohol consumption. In the context of social anxiety, the current research demonstrates the importance of examining problematic drinking as distinct constructs: alcohol consumption and negative consequences. Findings are also discussed in terms of implications for interventions with socially anxious students.     

Social anxiety and problematic alcohol consumption: the mediating role of drinking motives and situations

Social anxiety is inconsistently associated with alcohol use variables. To elucidate factors that contribute to the relationship between social anxiety and problematic alcohol use, the present study investigated drinking motives and drinking situations in an undergraduate sample (N = 293). Social anxiety was significantly correlated with endorsement of enhancement drinking motives (i.e., drinking to enhance positive experiences or emotions) but not social or coping motives. Social anxiety was also correlated with endorsement of drinking in the following high-risk situations: unpleasant emotions, conflict with others, social pressure, and testing personal control. Importantly, enhancement motives and each of these drinking situations mediated the relationship between social anxiety and alcohol-related problems. Findings suggest that alcohol use to enhance positive affect or in response to these specific situations may account for the risk for alcohol-related problems among those with social anxiety.     

The whys and the hows of psychosocial approaches to addiction

The field of addiction psychology attempts to addresses a major social problem. Yet, discourse within the discipline suggests a biological focus, driven by disease‐model of addiction, has caused our understanding to be too narrow. In contrast, psychosocial approaches conceptualize the phenomena from various perspectives. We here bring together papers utilizing a variety of methods in the context of substance use and mis‐use. These explore the effects that alcohol primes have on attentional control, how procrastination may predict hazardous drinking, the typology of “pre‐drinking” motivations and the effects of dyadic membership. It also looks at prevention in terms of public health messaging and also heroin use uptake. We hope showcasing these studies will encourage addiction researchers to widen the scope and method of their enquiries.     

Religion and Drinking in the Retirement Community

ABSTRACT

The effect of religiosity on drinking patterns of retirement community residents is examined. Based on a systematic random sample, residents of seven West Coast retirement communities were interviewed. Data on religiosity were categorized into social religious activity, and personal religious behavior. It was found that retirement community residents drink more than senior Americans living in other locations; conservative Protestants, identified as those claiming affiliation with denominations that prohibit alcohol consumption, drink less than Roman Catholics or liberal Protestants; and those who score low on religiosity drink more than those who score high on religiosity regardless of denominational affiliation. It was also shown that for conservative Protestants private religiosity predicts drinking behavior, and for liberal Protestants social religious behavior is a predictor variable. The influence of religiosity on drinking behavior was found to be significant.     

Putting the relationship between social anxiety and alcohol use into context: A daily diary investigation of drinking in response to embarrassing events

The goal of this study was to clarify mixed findings regarding the association between dispositional social anxiety and drinking among college students by using a daily diary method to examine whether a within-person social-contextual event moderated the relationship between social anxiety and alcohol use. College students (n = 476) completed a measure of dispositional social anxiety and then for 30 days reported whether they experienced an embarrassing event in public and the amount of alcohol they drank each day. We examined whether experiencing an embarrassing event moderated the relationship between dispositional social anxiety and alcohol use for same-day, same-evening, next-day, and next-evening drinking. While there was a positive relationship between dispositional social anxiety and alcohol use on evenings when an embarrassing event occurred earlier that day, this appeared to be driven by a reduction in drinking among those low in social anxiety. Individuals with high social anxiety drank in the evening regardless of embarrassing event occurrence. Results suggest that people with low social anxiety show an adaptive response to embarrassing events by lowering drinking on such evenings, while those with high social anxiety may drink to reduce their already high levels of anxiety independent of daily social events.     

Effects of early alcohol use on adolescents' relations with peers and self-esteem: patterns over time

Strain or problem-solving models posit that deviance persists because it enhances youths' psychosocial properties and is therefore functional for adolescents. However, empirical tests of this assumption have been limited to determining whether a moderately social activity like delinquency produces time-ordered changes in self-esteem. This research examines whether a highly social activity like alcohol use improves adolescents' relations with peers and self-esteem over time. The results of a four-year panel study show that the effects of early alcohol use are limited to enhancing peer relations only among adolescents who use alcohol in order to be part of the group. Early alcohol consumption also has a delayed effect on boosting self-esteem, but this effect is restricted to youths who equate drinking with sophistication. The lack of generality of these findings and how the psychological functions of drinking might cancel these effects are discussed.     

Personal and social correlates of alcohol consumption among mid‐adolescents

A prospective, cohort survey of 540 mid‐adolescent students was conducted to identify personal, family and social correlates of alcohol use. A structured questionnaire recorded alcohol involvement, other substance use, perceived parental alcohol use and related factors, alcohol‐related attitudes and beliefs, psychological well‐being, social and peer behaviours, and school conduct problems. Participants drank on 17.5 days in the past 3 months; on a typical drinking day they consumed 4.7 units, with 28.5% reported drinking six or more units. More frequent drinking was independently correlated with being male, perceiving that parents encouraged drinking, drinking without parental knowledge, drinking to alter mood, buying alcoholic beverages, spending more time with friends who drink, perceiving social pressure to drink, and being excluded from school and truanting. Parental discouragement for alcohol was related to more frequent drinking in females and less frequent drinking in males. Drinking more intensively was associated with use of cannabis, parental encouragement to drink, spending more time with friends who drink, school exclusion, and being in trouble with teachers. These results highlight multidimensional correlates of drinking during mid‐adolescence and underline the importance of addressing personal, family, peer, and school conduct factors in school‐based alcohol education programmes.     

Factors related to cigarette smoking and alcohol use among adolescents

Based on a national survey of Icelandic adolescents, this study examined the various predictors of cigarette smoking and alcohol use. It was found that the use of tobacco and alcohol was related to a number of different factors: sex, residence, hours of paid work, physical activities, social network, educational performance and beliefs, and psychological distress. Further, smoking and drinking had most predictors in common. It was concluded that existing theoretical perspectives on juvenile deviance do not provide an adequate account of adolescent smoking and drinking. The need to integrate existing theories into a wider explanatory framework is discussed.     

Life Satisfaction and Alcohol Consumption Among Young Adults at Social Gatherings

Although low life satisfaction is related to alcohol abuse among young adults, there is no clear evidence of a specific relationship between wellbeing indexes and alcohol consumption. Several studies have reported different nonlinear relationships. The role of other variables may explain the inconsistent relationships between life satisfaction and alcohol consumption. Concerning individual factors, people’s expectations regarding drinking alcohol (i.e., drinking motives) are considered the most proximal antecedents of alcohol use and may mediate the relationship between life satisfaction and drinking alcohol. Regarding relational factors, social relations are related to both wellbeing and alcohol consumption. The aim of the present study was to examine the relationships among life satisfaction, drinking motives, and alcohol consumption in a sample of young adults. The data were collected by means of a self-report questionnaire from a sample of 536 young adults (median age: 22 years). We tested a structural equation model, assuming the hypothesized relationships, simultaneously on males and females to investigate gender differences. The results showed the influence of social relations on life satisfaction, which in turn influenced participants’ expectations regarding drinking alcohol. Drinking motives were antecedents of alcohol use. Among women, low satisfaction increased coping expectation, which, in turn, increased alcohol consumption. The most dangerous expectation about drinking was that alcohol may enhance a person. Prevention campaigns should aim to deconstruct this idea.