Effect of the COMT Val158Met genotype on lateral prefrontal activations in young children

Low executive function (EF) during early childhood is a major risk factor for developmental delay, academic failure, and social withdrawal. Susceptible genes may affect the molecular and biological mechanisms underpinning EF. More specifically, genes associated with the regulation of prefrontal dopamine may modulate the response of prefrontal neurons during executive control. Several studies with adults and older children have shown that variants of the catechol‐O‐methyltransferase (COMT) gene are associated with behavioral performance and prefrontal activations in EF tasks. However, the effect of the COMT genotype on prefrontal activations during EF tasks on young children is still unknown. The present study examined whether a common functional polymorphism (Val158Met) in the COMT gene was associated with prefrontal activations and cognitive shifting in 3‐ to 6‐year‐old children. The study revealed that, compared with children with at least one Met allele (Met/Met and Met/Val), children who were Val homozygous (i) were more able to flexibly switch rules in cognitive shifting tasks and (ii) exhibited increased activations in lateral prefrontal regions during these tasks. This is the first evidence that demonstrates the relationship between a gene polymorphism and prefrontal activations in young children. It also indicates that COMT Val homozygosity may be advantageous for cognitive shifting and prefrontal functions, at least during early childhood, and children who possess this variant may have a lower risk of developing future cognitive and social development issues.     

Cool and Hot Aspects of Executive Function in Childhood Obsessive-Compulsive Disorder

Aspects of executive functioning (EF) have been put forward as endophenotypes in obsessive- compulsive disorder (OCD) and meta-analyses support EF underperformance in adult samples. Childhood-onset OCD has been suggested to constitute a separate neurodevelopmental subtype of the disorder but studies on neuropsychological functioning in childhood OCD are limited. The aim of the present study was to investigate performance-based EF in pediatric OCD using observed and latent variable analyses. A case-control design was applied including 50 unmedicated children and adolescents with OCD aged 7–17 years of which 70% were female, 50 pairwise age and gender matched non-psychiatric controls (NP) and 38 children and adolescents with mixed anxiety disorders (MA). Participants underwent structured diagnostic interviews and assessment with a battery encompassing cool EF tasks of working memory, set shifting, inhibition, and planning, and hot EF tasks of decision making and dot probe paradigm affective interference. First, groups were compared on observed variables with multilevel mixed-effects linear regression and analysis of variance. Then the latent structure of cool EF was tested with confirmatory factor analysis (CFA) and groups were compared on the CFA scores. No significant differences between groups appeared on individual cool EF tasks. On the hot EF tasks the OCD group displayed significant interference effects on the dot probe paradigm OCD-specific stimuli relative to NP, but not compared to MA and no group differences emerged for decision making. In the CFA a one-factor solution showed best fit, but the groups did not differ significantly on the resulting latent variable. The present study does not support cool or hot EF impairments in childhood OCD.     

Trait anxiety,visuospatial processing,and working memory

This experiment assessed the components of Baddeley's working memory system impaired by anxiety during performance of the Corsi Blocks Test. The Corsi task was performed concurrently with different secondary tasks (i.e., articulatory suppression; counting backwards; spatial tapping; simple tapping). Results showed Corsi performance depended mainly on the central executive and visuospatial sketchpad components of working memory. Adverse effects of trait anxiety on the Corsi task were observed on the central executive but not on the phonological loop or the visuospatial sketchpad. These effects were not mediated by state anxiety. The findings indicate for the first time that trait anxiety impairs central executive functioning on a nonverbal task, and that anxiety does not impair functioning of the “slave” systems (i.e., phonological loop; visuospatial sketchpad). Theoretical implications of these findings are discussed.     

Trait worry is associated with difficulties in working memory updating

The current study investigated the effects of trait worry, a subcomponent of trait anxiety, on the process of updating information in working memory (WM). A leading theory on anxiety and executive functions, attentional control theory (ACT), states that anxiety is not related to WM updating in emotionally neutral situations. Previous research, however, has focused almost exclusively on WM span tasks that primarily emphasised storage, rather than the updating of WM representations. Moreover, few studies have directly examined the effects of trait worry. In this study, 116 subjects performed a WM updating task that required the memorisation of short lists of words and the within-trial removal of some of these items from WM. Results indicated that levels of trait worry were not related to word-span performance, but were related to performance on trials that required subjects to effectively update WM. Moreover, these effects were observed only for trait worry, not for levels of anxious arousal or comorbid levels of dysphoria. These results support the hypothesis that trait worry is related to WM updating performance and thereby extend ACT in new directions.     

Are sluggish cognitive tempo symptoms associated with executive functioning in preschoolers?

The aim of this study is to investigate whether sluggish cognitive tempo (SCT) symptoms are associated with neurocognitive task performance and ratings of real-world executive functioning (EF) in preschoolers at risk for attention-deficit/hyperactivity disorder (ADHD). The associations between parent- and teacher-rated SCT symptoms and neuropsychological task performance and ratings of EF in 61 4-year-old preschool children (51 boys, 10 girls) with self-regulation difficulties were examined, with regression analyses controlling for the effects of ADHD inattention symptoms. In the study sample, higher teacher-rated SCT symptoms are significantly associated with poorer performance on tasks of visual-perceptual abilities, auditory and visual attention, sustained and selective attention, inhibitory control, pre-numerical/numerical concepts, and slower processing speed, but SCT symptoms are not significantly associated with working memory, attention shifting or cognitive flexibility when controlling for ADHD inattention. Higher parent-rated SCT symptoms are significantly associated with visual-perceptual abilities. ADHD inattention symptoms are more strongly associated than SCT with daily life EF ratings; neither parent- nor teacher-rated SCT symptoms are significantly associated with daily life ratings of inhibition, working memory, or planning/organization after controlling for ADHD inattention. This study suggests that SCT symptoms contribute to EF deficits at least on neurocognitive tasks assessing visual-perceptual/spatial abilities, attention to detail and processing speed, as observed in this sample of young children at risk for ADHD, and may be an important intervention target.     

Individual differences in anxiety and executive functioning: A multidimensional view

The relationship between individual differences in anxiety and executive functioning was investigated in a sample of young adults. Verbal and spatial working memory, resistance to interference, negative priming, and task‐switching measures were used to assess three executive functioning dimensions: updating, inhibition, and shifting. An additional index of basic psychomotor speed was added to this cognitive battery. According to the multidimensional interaction model of anxiety proposed by Endler (1997), state (cognitive–worry and autonomic–emotional) and trait (related to social evaluation, physical danger, ambiguous situations, and daily routines) anxiety were assessed in this evaluation context. Results indicated that shifting and inhibition (negative priming) efficiency were negatively related to state (cognitive–worry) and trait (related to social evaluation) anxiety. However, there was a relative advantage of subjects higher in social evaluation apprehensions in their memory updating performance. The results are consistent with several predictions of the attentional control theory (Eysenck, Derakshan, Santos, & Calvo, 2007), and are relevant for research regarding the interaction of situational, personality, and cognitive functioning dimensions.     

Executive functioning: Developmental consequences on adolescents with histories of maltreatment

Research suggests that children exposed to maltreatment have deficits in executive functioning (EF) but few studies have focused on the adolescent age group. We investigated whether maltreated adolescents had lower EF abilities compared to a group of non‐maltreated adolescents. Forty adolescents with histories of child maltreatment, together with a comparison group of 40 non‐maltreated adolescents matched for age, completed a comprehensive battery of EF tasks. Hierarchical multiple regression analyses, controlling for IQ, were carried out using each of the EF measures as dependent variables to examine group differences. Maltreated adolescents had significantly lower performance than non‐maltreated adolescents on tasks assessing executive loaded working memory, fluency, and inhibition, although switching was not impaired. Emotional and behavioural difficulties (EBD) were included in additional regression analyses to examine whether these variables would explain the group differences. The inclusion of EBD variables had some effect on group differences, as expected, but did not eliminate them. These findings support the theory that impairments in EF may be one underlying reason why adolescents with histories of maltreatment struggle to cope both inside and outside the classroom.     

Test anxiety,self-evaluative worry,and sleep disturbance in college students

Abstract

The present research examined the extent to which sleep disturbance is involved in the experience of test anxiety. In Study 1, a sample of 80 subjects completed a trait measure of test anxiety and completed a sleep inventory with reference to the past 30 days. In Study 2, a sample of 188 subjects provided measures of trait and state test anxiety and completed a sleep inventory for the night preceding an actual test. The results of Study 1 and Study 2 confirmed that test anxiety is associated with self-reported sleep disturbance. In addition, the results of Study 2 showed that sleep disturbance is also associated with increased state test anxiety. Finally, it was found in Study 2 that sleep disturbance was not related to actual test performance. However, poorer test performance was associated with increased state and trait test anxiety. It is concluded that certain characteristics associated with test anxiety are stable and may be detected in evaluative and non-evaluative situations. The results are discussed with particular reference to their implications for the test anxiety construct itself as well as treatment strategies for the test-anxious student.     

Iowa Gambling Task performance and executive function predict low-income urban preadolescents’ risky behaviors

This study examines preadolescents’ reports of risk-taking as predicted by two different, but related inhibitory control systems involving sensitivity to reward and loss on the one hand, and higher order processing in the context of cognitive conflict, known as executive functioning (EF), on the other. Importantly, this study examines these processes with a sample of inner-city, low-income preadolescents and as such examines the ways in which these processes may be related to risky behaviors as a function of children’s levels of both concurrent and chronic exposure to household poverty. As part of a larger longitudinal study, 382 children (ages 9–11) provided a self-report of risky behaviors and participated in the Iowa Gambling Task, assessing bias for infrequent loss (preference for infrequent, high magnitude versus frequent, low magnitude loss) and the Hearts and Flowers task assessing executive functioning. Results demonstrated that a higher bias for infrequent loss was associated with higher risky behaviors for children who demonstrated lower EF. Furthermore, bias for infrequent loss was most strongly associated with higher risk-taking for children facing highest levels of poverty. Implications for early identification and prevention of risk-taking in inner-city preadolescents are discussed.     

The involvement of executive functions in prospective memory performance of adults

The present study examines the relationship between prospective memory performance and executive functioning. The four phases of the prospective memory process—intention formation, intention retention, reinstantiation of the intention, and intention execution—are assumed to require different amounts of executive processing, most of which is demanded in the phases of intention formation and intention execution. At present, though, it is still unclear whether, and to what extent, prefrontal executive systems are involved in different kinds of prospective memory tasks, as some findings suggest that prospective memory might rather rely on nonstrategic processes that are unlikely to depend on prefrontal executive systems. Therefore, this study focuses on the following questions: (1) to what degree does executive functioning predict prospective memory performance in different standard prospective memory tasks and, furthermore, are certain executive measures better predictors than others; (2) are age‐related effects in different prospective memory measures due to individual differences in executive functioning; and (3) do age‐related differences in prospective memory exist that are not explained by individual differences in executive functioning. In a sample of 80 adults (20‐80 years), we applied four instruments to measure prospective memory: a traditional single‐task paradigm, two more complex tasks—one time‐based and one event‐based—and a highly complex multi‐task paradigm. We further assessed a broadly defined construct of executive functioning using several standard neuropsychological tests. Results showed that executive functioning did not predict performance in the simple single‐task paradigm. However, executive functioning, but not age, predicted performance in the two more complex standard tests of prospective remembering, and both executive functioning and age predicted performance in the most complex paradigm. In sum, the obtained data underline the assumption that frontal/ executive functions are related to prospective memory performance across a range of prospective paradigms. It also seems clear that age differences in prospective memory performance partially depend on age‐related individual differences in frontal/executive functions.     

The role of executive functioning in CBT: a pilot study with anxious older adults

Cognitive behavior therapy (CBT) is an effective treatment for late life anxiety and depression. The successful use of CBT is assumed to rely on cognitive skills known as executive functions (EF; e.g., hypothesis generation, allocation of attention, self-monitoring) governed by the prefrontal cortex. Because older adults sometimes have executive deficits as a consequence of normal aging, EF may be a mediator of CBT outcome in older samples. The current pilot study tested the hypothesis that older adults with executive deficits (as measured by neuropsychological tests) would show decreased therapeutic benefit from CBT for generalized anxiety disorder, as compared to a group with intact EF. Results indicated differential response to CBT within the dysfunction group depending on the stability (and possibly, the etiology) of executive deficits from pre- to posttreatment. Those whose EF scores remained low from pre- to posttreatment did not respond to CBT, while those whose scores improved responded quite well, similar to an Intact EF group. Results indicate that some, but not all, older adults with executive dysfunction show decreased benefit from CBT, and are consistent with the assumption that executive skills are important for the successful use of CBT. However, some participants may show improvement on both mood and cognitive skills during treatment, which is discussed further.     

“热”执行对注意缺陷多动障碍和阅读障碍儿童言语工作记忆的影响

ADHD儿童在与背外侧前额叶(DLPFC)相关的"冷"执行功能上的缺陷已大量证实,但在与眼眶和中前额叶皮层(OMPFC)相关的"热"执行功能上,ADHD儿童是否存在缺陷则未可知。与儿童赌博任务实验范式(该任务中"热"启动对"冷"执行起到抑制作用)不同,本研究考察趣味言语N-back任务是否对ADHD和阅读障碍儿童的成绩有促进作用。枯燥N-back任务考察的是言语工作记忆的纯认知特征,而趣味任务则卷入了"热"执行对"冷"执行的影响。结果表明,在枯燥任务上,ADHD和阅读障碍儿童的成绩均明显低于正常儿童,二者之间差异不显著,在趣味任务成绩上,ADHD儿童与正常儿童的成绩没有显著差异,而阅读障碍儿童成绩落后于正常控制组和ADHD组,在成绩变化的趋势上,ADHD儿童在趣味任务上成绩明显提高,而阅读障碍儿童则无明显改善。结果说明ADHD和阅读障碍儿童的言语工作记忆均存在明显的缺陷,但是机制不同,"热"执行对提高ADHD的言语工作记忆有明显的促进作用,ADHD的"冷"执行缺陷能够通过"热"执行的调节得到改善。     

Examining the relationship between performance-based and questionnaire assessments of executive function in young preterm children: Implications for clinical practice

The aim of this study was to determine whether specific performance-based executive function assessment tools were associated with executive functioning in everyday life as reported by parents and teachers of four- to five-year-old preterm and term children. At the age of 4 years, 141 preterm children born <33 weeks’ gestation and 77 term children were assessed using performance-based intelligence (WPPSI-III) and executive function (EF) assessment tools (NEPSY-II, Day-Night and Shape School tasks). The assessment results were compared with the parent and teacher completed questionnaires of EF (BRIEF-P) when the children started kindergarten at the age of 4 to 5 years. The performance-based intelligence and EF assessment results were not consistently associated with the parent and teacher reports of EF in everyday life for either preterm or term groups. Clinical implications of using and interpreting performance-based EF assessment tools and EF questionnaires are discussed with a particular focus on young preterm children at the commencement of formal schooling.     

Pregnancy hypertension and the risk for neuropsychological difficulties across early development: A brief report

Despite documented effects on fetal brain development, little is currently known about the relationship between maternal pregnancy hypertension and child neuropsychological outcomes. This brief report examined the association between maternal hypertension during pregnancy and children’s social cognition and executive functioning when children were 18 months, 3 years, and 4.5 years. A community sample of 501 families (23 hypertensive mothers; 478 nonhypertensive) was recruited when children were newborns. Social cognition (including theory of mind [ToM]) and executive functioning (EF) were measured using a battery of age-appropriate standardized and/or observational tasks. Information on pregnancy and prenatal factors were measured via maternal report when children were newborns. After controlling for prenatal and demographic covariates, the presence of hypertension difficulties during pregnancy was associated with all measures of social cognition, ToM, and EF. A secondary analysis comparing the hypertension group (n = 23) to a nonhypertensive matched control group (n = 23) supported the effect of pregnancy hypertension on children’s social-cognitive and EF development. Future studies using obstetrical records are encouraged based on these preliminary findings.     

Internalising symptoms and verbal working memory in school‐age children: A processing efficiency analysis

The current study investigated differential contributions of internalising symptoms (state anxiety, trait anxiety, depression) to school‐age children's verbal short‐term (STM) and working memory (WM) span accuracy and efficiency (microanalysis of response times). Children's (N = 125, M_age = 11.44 years) STM/WM was assessed with simple/complex span tasks. Our analyses revealed that: (a) children with high levels of state anxiety displayed reduced simple span accuracy (on Word span) and poorer efficiency on both simple (preparatory intervals, interword pauses) and complex span (preparatory intervals) response time segments; (b) trait anxiety was a negative predictor of children's complex span accuracy, as well as their efficiency on both simple (word durations) and complex span (interword pauses) response time measures; (3) depressive symptoms predicted longer simple span interword pauses. Findings indicate that while all internalising symptoms were predictive of children's poorer memory search efficiency, especially during the “silent”, executive intervals (interword pauses), anxiety symptoms were specifically predictive of children's impaired span accuracy and other efficiency indicators (preparatory intervals, word durations). The study highlights the differential contributions of state, trait anxiety, and depressive symptoms to STM/WM in children, emphasising the need to measure both accuracy and efficiency to assess the role that such symptoms play in children's performance.     

Exploring the relationship between executive functions and self-reported media-multitasking in young adults

Media-multitasking involves simultaneous engagement with information streams from multiple media sources, and is most prevalent in young adults. Heavy media-multitasking has been associated with differential performance on tasks involving attentional control and working memory relative to light media-multitasking. The aim of the present study was to systematically investigate relationships between executive functions and self-reported media-multitasking. Healthy participants (N?=?112, aged 18–25, male N?=?36) completed a battery of 10 traditional executive function tasks, that included assessments of attentional inhibition, response inhibition, working memory, and cognitive flexibility. Scores on the individual executive function tasks were correlated against frequency of self-reported media-multitasking, but no significant relationships were found. Trait anxiety, however, was found to be significantly associated with greater frequency of self-reported media-multitasking. The present study found no evidence of a relationship between the frequency of self-reported media-multitasking and executive functioning. The possible reasons for this are discussed.     

Differential relationship of recent self-reported stress and acute anxiety with divided attention performance

There have been relatively few studies on the relationship between recent perceived environmental stress and cognitive performance, and the existing studies do not control for state anxiety during the cognitive testing. The current study addressed this need by examining recent self-reported environmental stress and divided attention performance, while controlling for state anxiety. Fifty-four university undergraduates who self-reported a wide range of perceived recent stress (10-item perceived stress scale) completed both single and dual (simultaneous auditory and visual stimuli) continuous performance tests. Partial correlation analysis showed a statistically significant positive correlation between perceived stress and the auditory omission errors from the dual condition, after controlling for state anxiety and auditory omission errors from the single condition (r = 0.41). This suggests that increased environmental stress relates to decreased divided attention performance in auditory vigilance. In contrast, an increase in state anxiety (controlling for perceived stress) was related to a decrease in auditory omission errors from the dual condition (r = - 0.37), which suggests that state anxiety may improve divided attention performance. Results suggest that further examination of the neurobiological consequences of environmental stress on divided attention and other executive functioning tasks is needed.     

特质焦虑个体在高难度Stroop任务下的情绪启动效应

通过问卷法,选取特质焦虑和非特质焦虑被试作为本实验的研究对象,考察了正性、负性、中性三种不同的情绪对不同特质焦虑个体认知抑制的影响。在Stroop任务之前呈现三种情绪图片,结果发现,相比非特质焦虑被试,特质焦虑被试的Stroop效应量更大;特质焦虑被试和非特质焦虑被试在正性和负性情绪条件下的Stroop效应量均更大。说明特质焦虑被试的认知抑制功能存在不足,正性和负性情绪对特质焦虑和非特质焦虑被试的认知抑制均存在阻碍作用。     

Age-related changes in the efficiency of cognitive processing across the life span

The global-speed and the specific-gain/loss hypotheses have been dominant theoretical frameworks in the recent literature on cognitive development and aging. Few attempts have been made to explicitly assess the predictive power of the two frameworks against each other. We evaluated the extent to which age changes in performance in executive function tasks (involving response selection, response suppression, working memory, and adaptive control) depend on age-related changes in global information-processing speed. Our sample consisted of children, adolescents, adults and seniors. Analysis of covariance and structural equation modeling revealed a mixed pattern of results. Controlling for global speed removed the child vs. adult differences in the speed of responding on the executive function tasks but the senior vs. adult differences remained. This mixed pattern of findings was interpreted to suggest that the effects of advancing age on the speed of responding are mediated by a global mechanism during childhood but during senescence the efficiency of executive functioning seems particularly vulnerable to the effects of age.     

Parental reports of executive dysfunction in adolescents with bipolar disorder.

Bipolar disorder (BPD) is a serious mental illness that affects children and adolescents at a rate similar to that seen in adults. Extremely little is known, however, about cognitive functioning in childhood and adolescent BPD. The present study represents an initial effort to examine executive functioning in adolescents with BPD who are in a manic or mixed mood state, by collecting data from caregivers about the participants' performance on everyday tasks thought to be mediated by executive functioning abilities, using the Behavior Rating Inventory of Executive Function. In comparison to healthy volunteers, adolescents with BPD exhibited significant elevations across all of the measured functional domains. These elevations were evident even in adolescents with BPD who did not have comorbid ADHD, although they were most prominent in those with comorbidity. The findings suggest that adolescents with BPD have functional deficits on tasks requiring executive functioning skills that are not explicable solely on the basis of comorbid ADHD.