老龄活体供肾移植的临床应用

为缓解供体器官的严重短缺,老龄活体供肾移植逐渐成为一种可以接受的对策.老龄活体供肾移植有其特殊性并且更易于引发伦理争论.本文简要介绍此问题的研究现状,并就若干社会伦理学问题展开讨论.     

亲属肾移植的伦理学探讨

活体亲属肾移植是当前解决器官匮乏最重要的途径,近年来我国亲属肾移植例数也不断增多。但是亲属肾移植因其具有一定的特殊性,相比尸体供肾移植更为敏感,也更易于引发伦理问题。简要介绍国内外亲属肾移植的研究进展,重点对亲属肾移植的生命伦理学问题加以探讨。     

亲属肾移植的伦理学探讨

活体亲属肾移植是当前解决器官匮乏最重要的途径,近年来我国亲属肾移植例数也不断增多.但是亲属肾移植因其具有一定的特殊性,相比尸体供肾移植更为敏感,也更易于引发伦理问题.简要介绍国内外亲属肾移植的研究进展,重点对亲属肾移植的生命伦理学问题加以探讨.     

活体肾移植的道德与补偿原则

从１９５４年第一例活体肾移植手术成功至今,全世界肾移植患者超过２４万。我国近年来,活体肾移植数也有增大的趋势。虽然活体肾移植一年存活率为９２％～９６％,肾脏又是人体内成对的器官,但作为供体来说,贡献出一侧肾,很难说他仍是一个完全健康者。何况供器官切取...     

论开展亲属活体供肾移植的风险与对策

肾脏移植是救治终末期肾功能衰竭的最佳手段。亲属活体捐献肾脏是扩大供肾来源的有效手段。当前国内开展亲属肾移植存在伦理、法律和健康风险,主要来自供体和医疗两方面。为防范风险,医务人员应严格审查供受者的血缘关系,签署完整规范的法律文书,进行全面细致的术前评估,制定完善的手术方案。     

对我国儿童肾移植发展的思考与建议

肾移植是儿童终末期肾衰最重要的替代治疗手段。国内数家大的移植中心儿童肾移植长期存活率已接近国外先进水平,但我国肾移植患儿总数较少,主要原因是经费不足和供体缺乏。为推动儿童肾移植的发展,建议建立国家医疗救助制度,鼓励亲属活体肾脏捐献,严格掌握适应证,合理使用免疫抑制剂,加强多中心协作,建立移植随访网络。     

《人体器官移植条例》颁布后面临的问题与对策

《人体器官移植条例》规范引导着我国器官移植健康发展,然而,随着《条例》对器官移植供、受者条件的严格限制,尸体供器官数量迅速下降,亲属活体移植逐步占据主导地位,由此引发一系列问题。结合《条例》,就器官来源短缺、保障活体供者安全、亲属活体供者选择和器官移植伦理委员会作用等问题做出较详细的分析,提出解决方法和对策。     

对我国儿童肾移植发展的思考与建议

肾移植是儿童终末期肾衰最重要的替代治疗手段.国内数家大的移植中心儿童肾移植长期存活率已接近国外先进水平,但我国肾移植患儿总数较少,主要原因是经费不足和供体缺乏.为推动儿童肾移植的发展,建议建立国家医疗救助制度,鼓励亲属活体肾脏捐献,严格掌握适应证,合理使用免疫抑制剂,加强多中心协作,建立移植随访网络.     

肾源交换计划在中国开展的法学与伦理学探索

肾源交换计划的目的是为了建立活体肾源库,储备和扩大肾脏来源,缓解无心跳肾源供应的压力,尽可能减少因为配型不成功不能实施活体肾移植的情况,使更多的患者得到合适的肾脏.主要介绍肾源交换计划的起源与背景、概念及分类和他国的具体实践,总结他国的经验与问题,分析在不同国情下可能涉及到的法学与伦理学问题,并就肾源交换计划在我国当前国情下实施的可行性进行探讨.     

亲体肝移植的伦理学问题探讨

目前,肝移植已成为治疗终末期肝病的有效手段。活体肝移植术部分解决了供肝短缺的问题,10多年来其发展迅速,并取得了良好的疗效。由于活体肝移植需从活的供体身上切取部分肝脏,且供体多为患者家属,故存在着供体的选择、供体的贡献与代价,患者的家庭、心理、社会等伦理学问题。因此在提高活体肝移植技术水平的同时,必须充分考虑活体肝移植的伦理学问题,遵守伦理原则,使活体肝移植不但能从技术上达到,在伦理学方面也是可行的。     

开展活体器官移植的伦理学思考

活体器官移植起源于器官移植技术的最初阶段,目前已经成功开展了肾脏,肝脏,肺脏、小肠、脾脏等器官的活体移植手术,事实表明该技术不仅有其科学依据,而且有其伦理学依据,即以人类自身伟大的奉献精神来关爱他人。但开展这一技术时务必需要遵循知情自愿原则,生命价值原则,利益和风险并存原则。当然在积极肯定这一技术的同时,也应该看到这一技术也存在一些伦理学方面尚未解决的问题。     

活体肝移植的伦理学问题

目前,肝移植已成为治疗终末期肝病的有效手段,活体肝移植术部分解决了供肝短缺的问题,10多年来其发展迅速,并取得了良好的疗效,由于活体肝移植需从活的供体身上切取部分肝脏,且供体多为患者家属,故存在着供体的选择,供体的贡献与代价,患者的家庭,心理,社会等伦理等问题。因此在提高活体肝移植技术水平的同时,必须充分考虑活体肝移植的伦理学问题,遵守伦理原则,使活体肝移植不但能从技术上达到,在伦理学方面也是可行的。     

肾源交换计划

肾源交换计划的目的是尽可能减少活体肾移植中配型不成功造成的肾源损失,缓解肾脏供求矛盾,使更多的患者得到合适的肾脏。该计划已在许多国家实施且颇具成效。本文主要介绍肾源交换计划的概念、分类和他国的实施经验,分析可能涉及的伦理问题,总结他国取得的成效,并就肾源交换计划在我国实施的可行性进行探讨。     

Living donation and cosmetic surgery: a double standard in medical ethics?

The commitment of transplant physicians to protect the physical and psychological health of potential donors is fundamental to the process of living donor organ transplantation. It is appropriate that strict regulations to govern an individual's decision to donate have been developed. Some may argue that adherence to such regulations creates a doctor-patient relationship that is rooted in paternalism, which is in drastic contrast with a doctor-patient relationship that is rooted in patients' autonomy, characteristic of most other operative interventions. In this article we analyze the similarities between cosmetic plastic surgery and living donor surgery as examples of surgeries governed by different ethical principles. It is interesting that, while the prevailing ethical approach in living donor surgery is based on paternalism, the ethical principle guiding cosmetic surgery is respect for patients' autonomy. The purpose of this article is not to criticize either practice, but to suggest that, given the similarities between the two procedures, both operative interventions should be guided by the same ethical principle: a respect for patients' autonomy. We further suggest that if living organ donation valued donors' autonomy as much as cosmetic plastic surgery does, we might witness a wider acceptance of and increase in living organ donation.     

肝移植的伦理学问题

肝脏移植和其它器官移植一起实现了人类长期以来渴望生命再生的梦想,并成为终末期肝病的有效治疗方法。器官移植也面对许多伦理道德方面的难题。供体,特别是活体器官的摘取,受体的选择等,都受到社会道德观的制约。从伦理道德角度来分析如何制定相关的法律法规,成为当前社会关注的热点。从受体的利益、人体科研的道德规范以及相关制度的伦理学要求等方面,较为详细的阐述肝移植伦理学的基本原则。     

The ethical assessment of innovative therapies: Liver transplantation using living donors

Liver transplantation is the treatment of choice for many forms of liver disease. Unfortunately, the scarcity of cadaveric donor livers limits the availability of this technique. To improve the availability of liver transplantation, surgeons have developed the capability of removing a portion of liver from a live donor and transplanting it into a recipient. A few liver transplants using living donors have been performed worldwide. Our purpose was to analyze the ethics of liver transplants using living donors and to propose guidelines for the procedure before it was introduced in the United States. We used a process of “research ethics consultation” that involves a collaboration between clinical investigators and clinical ethicists. We concluded that it was ethically appropriate to perform liver transplantation using living donors in a small series of patients on a trial basis, and we published our ethical guidelines in a medical journal before the procedure was introduced. We recommend this prospective, public approach for the introduction of other innovative therapies in medicine and surgery.     

谈中医认知方式及中医理论体系的构建

提出开箱式思维和闭箱式思维的概念,并以此为基础对中医认知方式和中医理论体系的构建进行初步的探讨.整体上,中医认知方式是一种宏观性闭箱式思维,中医学是一种闭箱式理论体系.     

Effect of family environment and donor source on patient quality of life following renal transplantation.

The authors examined the degree to which the supportiveness of a patient's family environment predicts change in quality of life following renal transplantation. The sample consisted of 95 patients receiving renal grafts from either a living donor or a cadaveric donor. Patients were initially assessed prior to transplantation with follow-up assessment occurring an average of 5.5 months after transplantation. Among patients receiving a living-donor kidney, those reporting a more supportive family environment exhibited reduced depression, improved mobility, and improved social functioning. However, those living-donor recipients reporting less family support exhibited increased depression and diminished mobility and social functioning after transplantation. Patients receiving a kidney from a cadaveric donor showed modest improvements in quality of life regardless of the degree of family support.